ATE299372T1 - Antiparasitäre mittel - Google Patents

Antiparasitäre mittel

Info

Publication number
ATE299372T1
ATE299372T1 AT97938625T AT97938625T ATE299372T1 AT E299372 T1 ATE299372 T1 AT E299372T1 AT 97938625 T AT97938625 T AT 97938625T AT 97938625 T AT97938625 T AT 97938625T AT E299372 T1 ATE299372 T1 AT E299372T1
Authority
AT
Austria
Prior art keywords
antiparasitic agents
antiparasitic
agents
nodulisporium
fermentation
Prior art date
Application number
AT97938625T
Other languages
English (en)
Inventor
Kevin M Byrne
Arlene M Dahl
Anne W Dombrowski
Joyce A Greene
John G Ondeyka
Dan A Ostlind
Sheo B Singh
Diane M Vesey
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of ATE299372T1 publication Critical patent/ATE299372T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56Ring systems containing three or more rings
    • C07D209/80[b, c]- or [b, d]-condensed
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/14Ectoparasiticides, e.g. scabicides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56Ring systems containing three or more rings
    • C07D209/58[b]- or [c]-condensed
    • C07D209/70[b]- or [c]-condensed containing carbocyclic rings other than six-membered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14Fungi; Culture media therefor
    • C12N1/145Fungal isolates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10Nitrogen as only ring hetero atom
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12RINDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00Microorganisms ; Processes using microorganisms
    • C12R2001/645Fungi ; Processes using fungi
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/8215Microorganisms
    • Y10S435/911Microorganisms using fungi

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Indole Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
AT97938625T 1996-08-30 1997-08-26 Antiparasitäre mittel ATE299372T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2491196P 1996-08-30 1996-08-30
PCT/US1997/015015 WO1998008507A1 (en) 1996-08-30 1997-08-26 Antiparasitic agents

Publications (1)

Publication Number Publication Date
ATE299372T1 true ATE299372T1 (de) 2005-07-15

Family

ID=21822994

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97938625T ATE299372T1 (de) 1996-08-30 1997-08-26 Antiparasitäre mittel

Country Status (13)

Country Link
US (2) US5834260A (de)
EP (1) EP0938308B1 (de)
JP (1) JP3755898B2 (de)
AT (1) ATE299372T1 (de)
AU (1) AU713634B2 (de)
CA (1) CA2264066C (de)
DE (1) DE69733715T2 (de)
DK (1) DK0938308T3 (de)
ES (1) ES2244004T3 (de)
NZ (1) NZ333979A (de)
PT (1) PT938308E (de)
WO (1) WO1998008507A1 (de)
ZA (1) ZA977738B (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050245582A1 (en) * 2002-09-12 2005-11-03 The Hartz Mountain Corporation High concentration topical insecticides containing pyrethroids
US20040077703A1 (en) * 2002-10-02 2004-04-22 Soll Mark D. Nodulisporic acid derivative spot-on formulations for combating parasites
WO2005016356A1 (en) * 2003-08-08 2005-02-24 The Hartz Mountain Corporation Improved anthelmintic formulations
US7582612B2 (en) * 2004-03-12 2009-09-01 Hartz Mountain Corporation Multi-action anthelmintic formulations
US20060068020A1 (en) * 2004-09-24 2006-03-30 Cottrell Ian W Encapsulated pharmaceutical agents
US7348027B2 (en) * 2005-04-08 2008-03-25 Bayer Healthcare Llc Taste masked veterinary formulation
US20080306131A1 (en) * 2007-06-05 2008-12-11 Wyeth Progesterone receptor modulator and uses thereof
TWI556741B (zh) 2007-08-17 2016-11-11 英特威特國際股份有限公司 異唑啉組成物及其作為抗寄生蟲藥上的應用
CA2710171C (en) 2007-12-21 2016-02-02 Merial Limited The use of 6-halogeno-[1,2,4]-triazolo-[1,5-a]-pyrimidine compounds for combating pests in and on animals
NZ597929A (en) 2009-07-30 2013-09-27 Merial Ltd Insecticidal 4-amino-thieno[2,3-d]-pyrimidine compounds and methods of their use
EP2531506B1 (de) 2010-02-05 2014-05-14 Intervet International B.V. Spiroindolinverbindungen zur Verwendung als Anthelmintika
PL2621923T3 (pl) 2010-09-29 2017-08-31 Intervet International B.V. Związki n-heteroarylu z mostkami cyklicznymi do leczenia chorób pasożytniczych
CN105294549B (zh) 2010-09-29 2017-12-26 英特维特国际股份有限公司 N‑杂芳基化合物
US20140113934A1 (en) 2011-06-20 2014-04-24 E I Du Pont De Nemours And Company Heterocyclic compounds for treating helminth infections
US9096599B2 (en) 2011-08-04 2015-08-04 Intervet Inc. Spiroindoline compounds
JP2015502936A (ja) 2011-11-28 2015-01-29 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニーE.I.Du Pont De Nemours And Company スルホンアミド駆虫薬
US9321724B2 (en) 2012-03-28 2016-04-26 Intervet Inc. Heteroaryl compounds with A-cyclic bridging unit
EP2830615A1 (de) 2012-03-28 2015-02-04 Intervet International B.V. Heteroarylverbindungen mit cyclischer überbrückungseinheit zur verwendung bei der behandlung von helmintheninfektionen
WO2014099837A1 (en) 2012-12-18 2014-06-26 E. I. Du Pont De Nemours And Company Sulfonamide anthelmintics
AR111260A1 (es) 2017-03-31 2019-06-19 Intervet Int Bv Formulación farmacéutica de la sal de crotonil amino piridina
WO2020002593A1 (en) 2018-06-29 2020-01-02 Intervet International B.V. Compound for use against helminthic infection
MX2022007670A (es) 2019-12-18 2022-07-19 Intervet Int Bv Compuestos antihelminticos que comprenden una estructura de quinolina.
US12479841B2 (en) 2019-12-18 2025-11-25 Intervet, Inc. Anthelmintic compounds comprising azaindoles structure
CA3203279A1 (en) 2020-12-11 2022-06-16 Intervet International B.V. Anthelmintic compounds comprising a thienopyridine structure
WO2025027117A1 (en) 2023-08-02 2025-02-06 Intervet International B.V. Carboxamide-4-quinoline compounds with anthelmintic activity

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2805564B2 (ja) * 1992-08-13 1998-09-30 明治製菓株式会社 新規物質pf1101b物質及びその製造法
US5399582A (en) * 1993-11-01 1995-03-21 Merck & Co., Inc. Antiparasitic agents
US5492902A (en) * 1994-12-02 1996-02-20 The United States Of America As Represented By The Secretary Of Agriculture Indole antiinsectan metabolites from the ascostromata of Eupenicillium shearii
US5595991A (en) * 1995-03-20 1997-01-21 Merck & Co., Inc. Anthelmintic use of nodulisporic acid and analogs thereof
CZ294699B6 (cs) * 1995-03-20 2005-02-16 Merck And Co., Inc. Deriváty kyseliny nodulisporové a farmaceutický prostředek s jejich obsahem

Also Published As

Publication number Publication date
ZA977738B (en) 1998-03-02
PT938308E (pt) 2005-10-31
US5945317A (en) 1999-08-31
WO1998008507A1 (en) 1998-03-05
AU4091297A (en) 1998-03-19
CA2264066C (en) 2007-08-21
EP0938308A1 (de) 1999-09-01
CA2264066A1 (en) 1998-03-05
DE69733715D1 (de) 2005-08-18
DK0938308T3 (da) 2005-10-24
JP2001501176A (ja) 2001-01-30
EP0938308A4 (de) 2001-03-07
EP0938308B1 (de) 2005-07-13
DE69733715T2 (de) 2006-05-18
US5834260A (en) 1998-11-10
AU713634B2 (en) 1999-12-09
JP3755898B2 (ja) 2006-03-15
NZ333979A (en) 2000-08-25
ES2244004T3 (es) 2005-12-01

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