ATE299372T1 - Antiparasitäre mittel - Google Patents

Antiparasitäre mittel

Info

Publication number
ATE299372T1
ATE299372T1 AT97938625T AT97938625T ATE299372T1 AT E299372 T1 ATE299372 T1 AT E299372T1 AT 97938625 T AT97938625 T AT 97938625T AT 97938625 T AT97938625 T AT 97938625T AT E299372 T1 ATE299372 T1 AT E299372T1
Authority
AT
Austria
Prior art keywords
antiparasitic agents
antiparasitic
agents
nodulisporium
fermentation
Prior art date
Application number
AT97938625T
Other languages
English (en)
Inventor
Kevin M Byrne
Arlene M Dahl
Anne W Dombrowski
Joyce A Greene
John G Ondeyka
Dan A Ostlind
Sheo B Singh
Diane M Vesey
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of ATE299372T1 publication Critical patent/ATE299372T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/14—Ectoparasiticides, e.g. scabicides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungi isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
AT97938625T 1996-08-30 1997-08-26 Antiparasitäre mittel ATE299372T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2491196P 1996-08-30 1996-08-30
PCT/US1997/015015 WO1998008507A1 (en) 1996-08-30 1997-08-26 Antiparasitic agents

Publications (1)

Publication Number Publication Date
ATE299372T1 true ATE299372T1 (de) 2005-07-15

Family

ID=21822994

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97938625T ATE299372T1 (de) 1996-08-30 1997-08-26 Antiparasitäre mittel

Country Status (13)

Country Link
US (2) US5834260A (de)
EP (1) EP0938308B1 (de)
JP (1) JP3755898B2 (de)
AT (1) ATE299372T1 (de)
AU (1) AU713634B2 (de)
CA (1) CA2264066C (de)
DE (1) DE69733715T2 (de)
DK (1) DK0938308T3 (de)
ES (1) ES2244004T3 (de)
NZ (1) NZ333979A (de)
PT (1) PT938308E (de)
WO (1) WO1998008507A1 (de)
ZA (1) ZA977738B (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050245582A1 (en) * 2002-09-12 2005-11-03 The Hartz Mountain Corporation High concentration topical insecticides containing pyrethroids
US20040077703A1 (en) * 2002-10-02 2004-04-22 Soll Mark D. Nodulisporic acid derivative spot-on formulations for combating parasites
WO2005016356A1 (en) * 2003-08-08 2005-02-24 The Hartz Mountain Corporation Improved anthelmintic formulations
WO2005094210A2 (en) * 2004-03-12 2005-10-13 The Hartz Mountain Corporation Multi-action anthelmintic formulations
US20060068020A1 (en) * 2004-09-24 2006-03-30 Cottrell Ian W Encapsulated pharmaceutical agents
US7348027B2 (en) * 2005-04-08 2008-03-25 Bayer Healthcare Llc Taste masked veterinary formulation
US20080306131A1 (en) * 2007-06-05 2008-12-11 Wyeth Progesterone receptor modulator and uses thereof
TWI556741B (zh) 2007-08-17 2016-11-11 英特威特國際股份有限公司 異唑啉組成物及其作為抗寄生蟲藥上的應用
AU2008340434B2 (en) 2007-12-21 2014-02-06 Boehringer Ingelheim Animal Health USA Inc. The use of 6-halogeno-[1,2,4]-triazolo-[1,5-a]-pyrimidine compounds for combating pests in and on animals
AU2010278948B2 (en) 2009-07-30 2015-04-23 Boehringer Ingelheim Animal Health USA Inc. Insecticidal 4-Amino-thieno(2,3-d)-pyrimidine compounds and methods of their use
WO2011095581A1 (en) 2010-02-05 2011-08-11 Intervet International B.V. S piroindoline compounds for use as anthelminthi cs
RU2596185C2 (ru) 2010-09-29 2016-08-27 Интервет Интернэшнл Б.В. N-гетероарильные соединения
ES2624845T3 (es) 2010-09-29 2017-07-17 Intervet International B.V. Compuestos de N-heteroarilo con unidad de puente cíclico para el tratamiento de enfermedades parasitarias
US20140113934A1 (en) 2011-06-20 2014-04-24 E I Du Pont De Nemours And Company Heterocyclic compounds for treating helminth infections
WO2013017678A1 (en) 2011-08-04 2013-02-07 Intervet International B.V. Novel spiroindoline compounds
JP2015502936A (ja) 2011-11-28 2015-01-29 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニーE.I.Du Pont De Nemours And Company スルホンアミド駆虫薬
EP2831042B1 (de) 2012-03-28 2019-07-31 Intervet International B.V. Heteroaryl-verbindungen mit azyklischer brückeneinheit
WO2013144180A1 (en) 2012-03-28 2013-10-03 Intervet International B.V. Heteroaryl compounds with cyclic bridging unit for use in the treatment helminth infection
WO2014099837A1 (en) 2012-12-18 2014-06-26 E. I. Du Pont De Nemours And Company Sulfonamide anthelmintics
AR111260A1 (es) 2017-03-31 2019-06-19 Intervet Int Bv Formulación farmacéutica de la sal de crotonil amino piridina
WO2020002593A1 (en) 2018-06-29 2020-01-02 Intervet International B.V. Compound for use against helminthic infection
JP2023507173A (ja) 2019-12-18 2023-02-21 インターベット インターナショナル ベー. フェー. キノリン構造を含む駆虫剤化合物
MX2022007671A (es) 2019-12-18 2022-07-19 Intervet Int Bv Compuestos antihelminticos que comprenden una estructura de azaindoles.
WO2022122988A1 (en) 2020-12-11 2022-06-16 Intervet International B.V. Anthelmintic compounds comprising a thienopyridine structure
CN121620507A (zh) 2023-08-02 2026-03-06 英特维特国际股份有限公司 具有驱虫活性的甲酰胺-4-喹啉化合物
WO2026115027A1 (en) 2024-11-28 2026-06-04 Intervet International B.V. Carboxamide-4-quinoline compounds with anthelmintic activity

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2805564B2 (ja) * 1992-08-13 1998-09-30 明治製菓株式会社 新規物質pf1101b物質及びその製造法
US5399582A (en) * 1993-11-01 1995-03-21 Merck & Co., Inc. Antiparasitic agents
US5492902A (en) * 1994-12-02 1996-02-20 The United States Of America As Represented By The Secretary Of Agriculture Indole antiinsectan metabolites from the ascostromata of Eupenicillium shearii
CN1082814C (zh) * 1995-03-20 2002-04-17 麦克公司 球孢子酸衍生物
US5595991A (en) * 1995-03-20 1997-01-21 Merck & Co., Inc. Anthelmintic use of nodulisporic acid and analogs thereof

Also Published As

Publication number Publication date
AU4091297A (en) 1998-03-19
US5834260A (en) 1998-11-10
NZ333979A (en) 2000-08-25
ES2244004T3 (es) 2005-12-01
ZA977738B (en) 1998-03-02
AU713634B2 (en) 1999-12-09
WO1998008507A1 (en) 1998-03-05
JP3755898B2 (ja) 2006-03-15
CA2264066A1 (en) 1998-03-05
US5945317A (en) 1999-08-31
DE69733715D1 (de) 2005-08-18
DE69733715T2 (de) 2006-05-18
EP0938308A4 (de) 2001-03-07
DK0938308T3 (da) 2005-10-24
CA2264066C (en) 2007-08-21
JP2001501176A (ja) 2001-01-30
EP0938308B1 (de) 2005-07-13
PT938308E (pt) 2005-10-31
EP0938308A1 (de) 1999-09-01

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