BR9608115A - Vacinas de pertussis acelular e processos de preparação destas - Google Patents

Vacinas de pertussis acelular e processos de preparação destas

Info

Publication number
BR9608115A
BR9608115A BR9608115-5A BR9608115A BR9608115A BR 9608115 A BR9608115 A BR 9608115A BR 9608115 A BR9608115 A BR 9608115A BR 9608115 A BR9608115 A BR 9608115A
Authority
BR
Brazil
Prior art keywords
agglutinogens
pertussis vaccines
processes
preparation
acellular pertussis
Prior art date
Application number
BR9608115-5A
Other languages
English (en)
Portuguese (pt)
Inventor
John R Vose
Raafat E F Fahim
Gail E Jackson
Larry U L Tan
Original Assignee
Connaught Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/433,646 external-priority patent/US5877298A/en
Application filed by Connaught Lab filed Critical Connaught Lab
Publication of BR9608115A publication Critical patent/BR9608115A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/235—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bordetella (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/099—Bordetella
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55544—Bacterial toxins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
BR9608115-5A 1995-05-04 1996-05-02 Vacinas de pertussis acelular e processos de preparação destas BR9608115A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/433,646 US5877298A (en) 1995-05-04 1995-05-04 Acellular pertussis vaccines and methods of preparing thereof
US50174395A 1995-07-12 1995-07-12
PCT/CA1996/000278 WO1996034623A1 (en) 1995-05-04 1996-05-02 Acellular pertussis vaccines and methods of preparation thereof

Publications (1)

Publication Number Publication Date
BR9608115A true BR9608115A (pt) 2004-07-13

Family

ID=27029924

Family Applications (2)

Application Number Title Priority Date Filing Date
BR9608114-7A BR9608114A (pt) 1995-05-04 1996-05-02 Vacinas de pertussis a celular e processos para preparação das mesmas
BR9608115-5A BR9608115A (pt) 1995-05-04 1996-05-02 Vacinas de pertussis acelular e processos de preparação destas

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BR9608114-7A BR9608114A (pt) 1995-05-04 1996-05-02 Vacinas de pertussis a celular e processos para preparação das mesmas

Country Status (18)

Country Link
US (1) US6399076B2 (xx)
EP (7) EP1234580A1 (xx)
CN (2) CN100387618C (xx)
AT (3) ATE496634T1 (xx)
AU (2) AU710538B2 (xx)
BR (2) BR9608114A (xx)
CA (3) CA2433502A1 (xx)
DE (3) DE69638326D1 (xx)
DK (3) DK0824358T3 (xx)
ES (2) ES2180758T3 (xx)
FR (1) FR16C0015I2 (xx)
HK (1) HK1016191A1 (xx)
LU (1) LU93036I2 (xx)
MX (1) MX9708481A (xx)
NL (1) NL300804I2 (xx)
NZ (2) NZ306391A (xx)
PT (3) PT1393744E (xx)
WO (2) WO1996034883A1 (xx)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2646776B1 (fr) * 1989-05-12 1994-06-03 Pasteur Institut Utilisation de preparations vaccinantes a base d'adenyl cyclase ou de bacteries les produisant en tant qu'antigenes protecteurs contre les effets des bordetella
DE69511392T2 (de) * 1994-04-28 2000-03-23 Takeda Chemical Industries, Ltd. Verfahren zur trennung von protektiven verbindungen aus bordetella pertussis
US6696065B1 (en) * 1995-05-04 2004-02-24 Aventis Pastuer Limited Acellular pertussis vaccines and methods of preparation thereof
GB9611501D0 (en) * 1996-06-03 1996-08-07 Smithkline Beecham Biolog Vaccine compositions
RU2194531C2 (ru) * 1996-07-02 2002-12-20 Коннот Лабораториз Лимитед Поливалентные ассоциированные коклюшно-дифтерийно-столбнячно (акдс)-полиомиелитные вакцины
JP4530317B2 (ja) * 1998-10-21 2010-08-25 学校法人北里研究所 減毒化トキシンを含むワクチン製剤
KR101337320B1 (ko) * 2003-11-20 2013-12-06 사노피 파스퇴르 인크 백일해 독소의 정제방법 및 이에 유용한 펩타이드
EP1828378B1 (en) * 2004-12-17 2014-06-11 De Staat der Nederlanden, vert. door de minister Van VWS, Ministerie van Volksgezondheid, Welzijn en Sport Deacylation of lps in gram negative bacteria
ES2423663T3 (es) 2005-08-08 2013-09-23 Oregon Health And Science University Inactivación de patógenos con peróxido de hidrógeno para la producción de vacunas
EP1867638A1 (de) * 2006-06-16 2007-12-19 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Verfahren zur kovalenten Verknüpfung zweier Moleküle mittels Diels-Alder-Reaktion mit inversem Elektronenbedarf
MX2009002560A (es) 2006-09-07 2009-03-20 Glaxosmithkline Biolog Sa Vacuna.
CN100537767C (zh) * 2007-04-29 2009-09-09 中国药品生物制品检定所 百日咳疫苗保护性抗原的重组表达及其应用
GB0822633D0 (en) * 2008-12-11 2009-01-21 Novartis Ag Formulation
US20100330158A1 (en) * 2009-03-31 2010-12-30 Innopharma, Llc Protein-assisted drug delivery system for the targeted administration of active agents
EP2430040A1 (en) 2009-05-11 2012-03-21 Novartis AG Antigen purification process for pertactin antigen
WO2013043608A1 (en) * 2011-09-20 2013-03-28 Bio-Rad Laboratories, Inc. Removal of virucidal agents from biomolecule preparations
WO2013049535A2 (en) 2011-09-30 2013-04-04 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Influenza vaccine
CN102584958A (zh) * 2012-02-08 2012-07-18 北京天坛生物制品股份有限公司 百日咳杆菌69kd外膜蛋白的纯化方法
CN102793915B (zh) * 2012-07-25 2013-10-23 天津康希诺生物技术有限公司 一种无细胞百日咳疫苗的生产方法
US8916173B2 (en) 2013-03-08 2014-12-23 Crucell Holland B.V. Acellular pertussis vaccine
EP3302784B1 (en) 2015-06-05 2021-10-06 W.R. Grace & Co.-Conn. Adsorbent bioprocessing clarification agents and methods of making and using the same
CN105106947A (zh) * 2015-07-21 2015-12-02 华兰生物工程股份有限公司 过氧化氢脱毒的无细胞百日咳疫苗及其制备方法
EP3518968B1 (en) 2016-10-03 2022-01-05 The U.S.A. as represented by the Secretary, Department of Health and Human Services Hiv-1 env fusion peptide immunogens and their use
WO2018081832A1 (en) 2016-10-31 2018-05-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Peptide fragments from filoviruses and their uses
US11235056B2 (en) 2017-03-24 2022-02-01 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Glycan-masked engineered outer domains of HIV-1 gp120 and their use
KR102426041B1 (ko) * 2017-08-01 2022-07-29 주식회사 녹십자 냉동 및 해동 과정을 포함하는 백일해균 유래 단백질 수득 방법
WO2019079337A1 (en) 2017-10-16 2019-04-25 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services RECOMBINANT HIV-1 ENVELOPE PROTEINS AND THEIR USE
WO2020061564A1 (en) 2018-09-23 2020-03-26 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Hiv-1 env fusion peptide nanoparticle carrier conjugates and their use
AU2019368218A1 (en) 2018-10-22 2021-05-27 New York University Recombinant GP120 protein with V1-loop deletion
CN110358802B (zh) * 2019-08-16 2021-06-18 长春百克生物科技股份公司 一种去除百日咳组分菌毛蛋白2/3内毒素的方法
CN112094354B (zh) * 2020-11-05 2021-02-02 苏州世诺生物技术有限公司 副鸡禽杆菌基因工程亚单位疫苗、其制备方法及应用
EP4380613A1 (en) 2021-08-03 2024-06-12 The United States of America, as represented by the Secretary, Department of Health and Human Services Hiv-1 vaccination and samt-247 microbicide to prevent hiv-1 infection
WO2023192835A1 (en) 2022-03-27 2023-10-05 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Base-covered hiv-1 envelope ectodomains and their use
CN117417419B (zh) * 2023-01-10 2024-04-19 康希诺生物股份公司 一种百日咳毒素脱毒方法及无细胞百白破联合疫苗

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4258029A (en) 1979-04-23 1981-03-24 Connaught Laboratories Limited Synthetic adjuvants for stimulation of antigenic responses
DE3521994A1 (de) 1985-06-20 1987-01-02 Bayer Ag N-(2-aminoacylamido-2-desoxy-hexosyl)-amide-, -carbamate und -harnstoffe, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
GB8601279D0 (en) * 1986-01-20 1986-02-26 Public Health Lab Service Purification of pertussis antigens
US4705686A (en) 1986-05-09 1987-11-10 American Cyanamid Process for the preparation of acellular Bordetalla pertussis vaccine
KR0168039B1 (ko) * 1987-09-04 1999-01-15 로버트 디. 웨스트 재조합 dna에서 유도한 보르데텔라 외독소 소단위체의 유사체 및 그를 포함하는 백신
GB8727489D0 (en) 1987-11-24 1987-12-23 Connaught Lab Detoxification of pertussis toxin
GB8807860D0 (en) 1988-04-05 1988-05-05 Connaught Lab Pertussis vaccine
US4967176A (en) * 1988-07-15 1990-10-30 Raychem Corporation Assemblies of PTC circuit protection devices
US5101014A (en) 1989-02-10 1992-03-31 United States Of America Process for the purification of a 69,000 da outer membrane protein of Bordetella pertussis
AU5432690A (en) * 1989-03-31 1990-11-05 Washington University Bordetella vaccines
US5276142A (en) 1989-12-11 1994-01-04 American Cyanamid Company Process for purification of a 69000 dalton antigenic protein from Bordetella pertussis
GB9007657D0 (en) * 1990-04-04 1990-05-30 Connaught Lab Purification of a pertussis outer membrane protein(omp69)
EP0484621A3 (en) * 1990-07-11 1992-08-26 American Cyanamid Company Efficacious vaccines against bordetella pertussis comprising a combination of individually purified pertussis antigens
DE69511392T2 (de) * 1994-04-28 2000-03-23 Takeda Chemical Industries, Ltd. Verfahren zur trennung von protektiven verbindungen aus bordetella pertussis
FR2728170A1 (fr) * 1994-12-15 1996-06-21 Pasteur Institut Vaccin de type acellulaire anti-bordetella
US5877298A (en) * 1995-05-04 1999-03-02 Connaught Lab Acellular pertussis vaccines and methods of preparing thereof

Also Published As

Publication number Publication date
DE69622555D1 (de) 2002-08-29
ATE496634T1 (de) 2011-02-15
LU93036I2 (fr) 2016-06-21
CN1198099A (zh) 1998-11-04
DE69638326D1 (de) 2011-03-10
CA2220063C (en) 2003-08-26
AU710538B2 (en) 1999-09-23
US20010009666A1 (en) 2001-07-26
DE69622555T2 (de) 2003-03-27
FR16C0015I1 (xx) 2016-06-10
HK1016191A1 (en) 1999-10-29
AU5494196A (en) 1996-11-21
EP0824358B1 (en) 2002-12-04
CN100387618C (zh) 2008-05-14
EP0826001A1 (en) 1998-03-04
FR16C0015I2 (fr) 2017-06-09
DE69625191D1 (de) 2003-01-16
WO1996034623A1 (en) 1996-11-07
ATE228851T1 (de) 2002-12-15
AU715417B2 (en) 2000-02-03
NL300804I2 (xx) 2016-11-01
PT826001E (pt) 2002-12-31
CA2220048A1 (en) 1996-11-07
CA2433502A1 (en) 1996-11-07
PT1393744E (pt) 2011-05-03
CA2220048C (en) 2006-03-07
AU5494096A (en) 1996-11-21
MX9708481A (es) 1998-02-28
BR9608114A (pt) 2000-10-31
ES2180758T3 (es) 2003-02-16
EP1234579A1 (en) 2002-08-28
CA2220063A1 (en) 1996-11-07
WO1996034883A1 (en) 1996-11-07
PT824358E (pt) 2003-02-28
US6399076B2 (en) 2002-06-04
NZ306392A (en) 1999-04-29
EP1405643A1 (en) 2004-04-07
EP1233022B1 (en) 2015-12-09
DE69625191T2 (de) 2003-07-10
NZ306391A (en) 1999-03-29
DK0824358T3 (da) 2003-01-27
EP1393744A1 (en) 2004-03-03
DK1393744T3 (da) 2011-05-30
EP1234580A1 (en) 2002-08-28
ES2182971T3 (es) 2003-03-16
EP1233022A1 (en) 2002-08-21
EP1393744B1 (en) 2011-01-26
EP0826001B1 (en) 2002-07-24
DK0826001T3 (da) 2002-11-18
CN1193324A (zh) 1998-09-16
ATE221081T1 (de) 2002-08-15
EP0824358A1 (en) 1998-02-25

Similar Documents

Publication Publication Date Title
BR9608115A (pt) Vacinas de pertussis acelular e processos de preparação destas
EP0154344A3 (en) Antiviral pharmaceutical preparations and methods for their use
CA2095854A1 (en) Mycobacterium vaccae in the treatment of uveitis
ES2088778T3 (es) Destoxificacion de la toxina de la tos ferina.
NO994256L (no) Små molekyler som er anvendelige ved behandling av inflammasjonssykdom
DE3773952D1 (de) Impfmittel fuer gusseisen oder duktiles gusseisen.
ES8202058A1 (es) Metodo de producir toxoide de pertussis
DK548986A (da) Praeparat til behandling af acne vulgaris og fremgangsmaade til dets fremstilling og anvendelse
ATE193442T1 (de) 3,4-diarylchromane zur behandlung von dermatitis
DK232483A (da) Fremgangsmaade til fremstilling af ws 6049-forbindelser
ATE68001T1 (de) 11-beta-nitrat-substituierte estrane.
DE69429365D1 (de) Entzündungshemmende zusammensetzung und methode, in welchen des-tyr dynorphin und analoge benutzt werden
UA26403A (uk) Похідhі n-заміщеhого 4-феhіл-4-піперидиhкарбоксаміду та їх фармацевтичhо прийhятhі солі, що проявляють аhестезувальhу та аhальгезувальhу дію, спосіб їх одержаhhя та фармацевтичhа композиція
ES8303522A1 (es) Procedimiento para la mutacion doble de virus del genero herpes
YU242390A (sh) Matrica s celicami, vezanimi nanjo adherentno, kot tudi postopek za proizvodnjo virusa/virusantigena
DE3485017D1 (de) Antikoerper und antikoerper enthaltende zubereitungen fuer die inhibition von periodontitis.
EP0090660A3 (en) Neisseria gonorrhoeae vaccine
ATE420951T1 (de) Schützende epitope von adenylate-zyklase- hämolysin(ac-hly) und ihre verwendung zur behandlung oder verhütung von bordetella- infektionen
MX9708480A (es) Vacunas acelulares de pertussis y metodos de preparacion de las mismas.
BR8505164A (pt) Variedade m4s da pseudomonas solanacearum,composicoes contendo as mesmas para controle de doencas do solo de plantas solanaceas,e processos usando as mesmas para controle de doencas do solo de plantas solanaceas
DE69615685D1 (de) Impstoff gegen krankheitserreger, zusammensetzung zur behandlung und vorbeugung von hiv infektionen
BR8706053A (pt) Processo para a preparacao de cepa mutante aperfeicoada de bordetella bronchiseptica,e vacina de germe atenuado ar produzida da mesma
DK0571520T3 (da) Anvendelse af pycnogenoler til fremstilling af lægemidler med anti-inflammatorisk aktivitet
FR2580176B1 (fr) Vaccin antirabique avirulent
FR2589063B1 (fr) Procede de culture de babesia canis, application a la preparation d'antigenes et de vaccins, et antigenes et vaccins contre la piroplasmose

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08H Application fees: decision cancelled [chapter 8.8 patent gazette]

Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 1762 DE 20041013 POR TEREM SIDO APRESENTADAS COPIAS DE PETICOES.

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PRESENTE PEDIDO DE PATENTE COMO INVENCAO DE ACORDO COM O ART. 8O DA LPI.