PT1393744E - Vacinas acelulares contra a tosse convulsa e m?todos para a sua prepara??o - Google Patents

Vacinas acelulares contra a tosse convulsa e m?todos para a sua prepara??o Download PDF

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Publication number
PT1393744E
PT1393744E PT03078355T PT03078355T PT1393744E PT 1393744 E PT1393744 E PT 1393744E PT 03078355 T PT03078355 T PT 03078355T PT 03078355 T PT03078355 T PT 03078355T PT 1393744 E PT1393744 E PT 1393744E
Authority
PT
Portugal
Prior art keywords
pref
iii
pertussis
toxoid
agg
Prior art date
Application number
PT03078355T
Other languages
English (en)
Inventor
John Thipphawong
Luis Barreto
John R Vose
Raafat E Fahim
Gail E D Jackson
Larry U L Tan
Andrew Herbert
Leslie Boux
Michael H Klein
Original Assignee
Sanofi Pasteur Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/433,646 external-priority patent/US5877298A/en
Application filed by Sanofi Pasteur Ltd filed Critical Sanofi Pasteur Ltd
Publication of PT1393744E publication Critical patent/PT1393744E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/235—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bordetella (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/099—Bordetella
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55544—Bacterial toxins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
PT03078355T 1995-05-04 1996-05-02 Vacinas acelulares contra a tosse convulsa e m?todos para a sua prepara??o PT1393744E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/433,646 US5877298A (en) 1995-05-04 1995-05-04 Acellular pertussis vaccines and methods of preparing thereof
US50174395A 1995-07-12 1995-07-12

Publications (1)

Publication Number Publication Date
PT1393744E true PT1393744E (pt) 2011-05-03

Family

ID=27029924

Family Applications (3)

Application Number Title Priority Date Filing Date
PT96911886T PT824358E (pt) 1995-05-04 1996-05-02 Vacinas acelulares contra a tosse convulsa e metodos para sua preparacao
PT96911887T PT826001E (pt) 1995-05-04 1996-05-02 Vacinas acelulares contra a tosse convulsa e metodos para a sua preparacao
PT03078355T PT1393744E (pt) 1995-05-04 1996-05-02 Vacinas acelulares contra a tosse convulsa e m?todos para a sua prepara??o

Family Applications Before (2)

Application Number Title Priority Date Filing Date
PT96911886T PT824358E (pt) 1995-05-04 1996-05-02 Vacinas acelulares contra a tosse convulsa e metodos para sua preparacao
PT96911887T PT826001E (pt) 1995-05-04 1996-05-02 Vacinas acelulares contra a tosse convulsa e metodos para a sua preparacao

Country Status (18)

Country Link
US (1) US6399076B2 (pt)
EP (7) EP0826001B1 (pt)
CN (2) CN100387618C (pt)
AT (3) ATE496634T1 (pt)
AU (2) AU710538B2 (pt)
BR (2) BR9608114A (pt)
CA (3) CA2220048C (pt)
DE (3) DE69638326D1 (pt)
DK (3) DK0826001T3 (pt)
ES (2) ES2180758T3 (pt)
FR (1) FR16C0015I2 (pt)
HK (1) HK1016191A1 (pt)
LU (1) LU93036I2 (pt)
MX (1) MX9708481A (pt)
NL (1) NL300804I2 (pt)
NZ (2) NZ306391A (pt)
PT (3) PT824358E (pt)
WO (2) WO1996034883A1 (pt)

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FR2646776B1 (fr) * 1989-05-12 1994-06-03 Pasteur Institut Utilisation de preparations vaccinantes a base d'adenyl cyclase ou de bacteries les produisant en tant qu'antigenes protecteurs contre les effets des bordetella
DK0755403T3 (da) * 1994-04-28 2000-02-14 Takeda Chemical Industries Ltd Fremgangsmåde til adskillelse af beskyttende komponenter fra Bordetalla pertussis
US6696065B1 (en) 1995-05-04 2004-02-24 Aventis Pastuer Limited Acellular pertussis vaccines and methods of preparation thereof
GB9611501D0 (en) * 1996-06-03 1996-08-07 Smithkline Beecham Biolog Vaccine compositions
EP1762246A1 (en) * 1996-07-02 2007-03-14 Sanofi Pasteur Limited Multivalent DTP-Polio vaccines
DE69939943D1 (de) * 1998-10-21 2009-01-02 Kitasato Inst Attenuierte Toxine als Adjuvantien
WO2005051985A2 (en) * 2003-11-20 2005-06-09 Sanofi Pasteur, Inc. Methods for purifying pertussis toxin and peptides useful therefor
EP1828378B1 (en) * 2004-12-17 2014-06-11 De Staat der Nederlanden, vert. door de minister Van VWS, Ministerie van Volksgezondheid, Welzijn en Sport Deacylation of lps in gram negative bacteria
ES2423663T3 (es) 2005-08-08 2013-09-23 Oregon Health And Science University Inactivación de patógenos con peróxido de hidrógeno para la producción de vacunas
EP1867638A1 (de) * 2006-06-16 2007-12-19 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Verfahren zur kovalenten Verknüpfung zweier Moleküle mittels Diels-Alder-Reaktion mit inversem Elektronenbedarf
CA2662064A1 (en) 2006-09-07 2008-03-13 Glaxosmithkline Biologicals S.A. Method of producing a combination polivirus vaccine
CN100537767C (zh) * 2007-04-29 2009-09-09 中国药品生物制品检定所 百日咳疫苗保护性抗原的重组表达及其应用
GB0822633D0 (en) * 2008-12-11 2009-01-21 Novartis Ag Formulation
US20100330158A1 (en) * 2009-03-31 2010-12-30 Innopharma, Llc Protein-assisted drug delivery system for the targeted administration of active agents
WO2010131111A1 (en) 2009-05-11 2010-11-18 Novartis Ag Antigen purification process for pertactin antigen
US20130267690A1 (en) * 2011-09-20 2013-10-10 Bio-Rad Laboratories, Inc. Removal of virucidal agents from biomolecule preparations
WO2013049535A2 (en) 2011-09-30 2013-04-04 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Influenza vaccine
CN102584958A (zh) * 2012-02-08 2012-07-18 北京天坛生物制品股份有限公司 百日咳杆菌69kd外膜蛋白的纯化方法
CN102793915B (zh) * 2012-07-25 2013-10-23 天津康希诺生物技术有限公司 一种无细胞百日咳疫苗的生产方法
PE20151720A1 (es) 2013-03-08 2015-12-10 Crucell Holland Bv Vacuna acelular contra pertussis
KR102566292B1 (ko) 2015-06-05 2023-08-10 더블유.알. 그레이스 앤드 캄파니-콘. 흡착성 바이오프로세싱 정화제와 이의 제조 및 사용 방법
CN105106947A (zh) * 2015-07-21 2015-12-02 华兰生物工程股份有限公司 过氧化氢脱毒的无细胞百日咳疫苗及其制备方法
EP3518968B1 (en) 2016-10-03 2022-01-05 The U.S.A. as represented by the Secretary, Department of Health and Human Services Hiv-1 env fusion peptide immunogens and their use
US11202824B2 (en) 2016-10-31 2021-12-21 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Peptide fragments from filoviruses and their uses
US11235056B2 (en) 2017-03-24 2022-02-01 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Glycan-masked engineered outer domains of HIV-1 gp120 and their use
KR102426041B1 (ko) * 2017-08-01 2022-07-29 주식회사 녹십자 냉동 및 해동 과정을 포함하는 백일해균 유래 단백질 수득 방법
EP3697440A1 (en) 2017-10-16 2020-08-26 The United States of America, as represented by the Secretary, Department of Health and Human Services Recombinant hiv-1 envelope proteins and their use
US20210353740A1 (en) 2018-09-23 2021-11-18 The United States Of America, As Represented By The Secretary, Department Of Health And Human Servic Hiv-1 env fusion peptide nanoparticle carrier conjugates and their use
US20210340188A1 (en) 2018-10-22 2021-11-04 The United States Of America, As Represented By The Secretary, Department Of Health And Human Servic Recombinant gp120 protein with v1-loop deletion
CN110358802B (zh) * 2019-08-16 2021-06-18 长春百克生物科技股份公司 一种去除百日咳组分菌毛蛋白2/3内毒素的方法
CN112094354B (zh) * 2020-11-05 2021-02-02 苏州世诺生物技术有限公司 副鸡禽杆菌基因工程亚单位疫苗、其制备方法及应用
WO2023015186A1 (en) 2021-08-03 2023-02-09 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Hiv-1 vaccination and samt-247 microbicide to prevent hiv-1 infection
WO2023192835A1 (en) 2022-03-27 2023-10-05 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Base-covered hiv-1 envelope ectodomains and their use

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US4258029A (en) 1979-04-23 1981-03-24 Connaught Laboratories Limited Synthetic adjuvants for stimulation of antigenic responses
DE3521994A1 (de) 1985-06-20 1987-01-02 Bayer Ag N-(2-aminoacylamido-2-desoxy-hexosyl)-amide-, -carbamate und -harnstoffe, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
GB8601279D0 (en) * 1986-01-20 1986-02-26 Public Health Lab Service Purification of pertussis antigens
US4705686A (en) 1986-05-09 1987-11-10 American Cyanamid Process for the preparation of acellular Bordetalla pertussis vaccine
KR0168039B1 (ko) * 1987-09-04 1999-01-15 로버트 디. 웨스트 재조합 dna에서 유도한 보르데텔라 외독소 소단위체의 유사체 및 그를 포함하는 백신
GB8727489D0 (en) 1987-11-24 1987-12-23 Connaught Lab Detoxification of pertussis toxin
GB8807860D0 (en) 1988-04-05 1988-05-05 Connaught Lab Pertussis vaccine
US4967176A (en) * 1988-07-15 1990-10-30 Raychem Corporation Assemblies of PTC circuit protection devices
US5101014A (en) 1989-02-10 1992-03-31 United States Of America Process for the purification of a 69,000 da outer membrane protein of Bordetella pertussis
WO1990012086A1 (en) * 1989-03-31 1990-10-18 Washington University Bordetella vaccines
US5276142A (en) 1989-12-11 1994-01-04 American Cyanamid Company Process for purification of a 69000 dalton antigenic protein from Bordetella pertussis
GB9007657D0 (en) * 1990-04-04 1990-05-30 Connaught Lab Purification of a pertussis outer membrane protein(omp69)
EP0484621A3 (en) * 1990-07-11 1992-08-26 American Cyanamid Company Efficacious vaccines against bordetella pertussis comprising a combination of individually purified pertussis antigens
DK0755403T3 (da) * 1994-04-28 2000-02-14 Takeda Chemical Industries Ltd Fremgangsmåde til adskillelse af beskyttende komponenter fra Bordetalla pertussis
FR2728170A1 (fr) * 1994-12-15 1996-06-21 Pasteur Institut Vaccin de type acellulaire anti-bordetella
US5877298A (en) * 1995-05-04 1999-03-02 Connaught Lab Acellular pertussis vaccines and methods of preparing thereof

Also Published As

Publication number Publication date
NL300804I2 (pt) 2016-11-01
EP1233022A1 (en) 2002-08-21
FR16C0015I1 (pt) 2016-06-10
PT826001E (pt) 2002-12-31
DE69638326D1 (de) 2011-03-10
EP0826001B1 (en) 2002-07-24
AU715417B2 (en) 2000-02-03
CN1198099A (zh) 1998-11-04
ATE221081T1 (de) 2002-08-15
MX9708481A (es) 1998-02-28
EP1234579A1 (en) 2002-08-28
EP1393744A1 (en) 2004-03-03
BR9608115A (pt) 2004-07-13
AU5494196A (en) 1996-11-21
AU5494096A (en) 1996-11-21
BR9608114A (pt) 2000-10-31
CA2220048C (en) 2006-03-07
CA2220063A1 (en) 1996-11-07
US6399076B2 (en) 2002-06-04
DE69622555D1 (de) 2002-08-29
EP1405643A1 (en) 2004-04-07
EP0824358B1 (en) 2002-12-04
DK0826001T3 (da) 2002-11-18
CA2220048A1 (en) 1996-11-07
NZ306392A (en) 1999-04-29
CA2220063C (en) 2003-08-26
EP0824358A1 (en) 1998-02-25
DK1393744T3 (da) 2011-05-30
ES2180758T3 (es) 2003-02-16
EP1393744B1 (en) 2011-01-26
DK0824358T3 (da) 2003-01-27
DE69625191T2 (de) 2003-07-10
ATE496634T1 (de) 2011-02-15
DE69622555T2 (de) 2003-03-27
NZ306391A (en) 1999-03-29
DE69625191D1 (de) 2003-01-16
EP1234580A1 (en) 2002-08-28
CA2433502A1 (en) 1996-11-07
LU93036I2 (fr) 2016-06-21
US20010009666A1 (en) 2001-07-26
PT824358E (pt) 2003-02-28
CN100387618C (zh) 2008-05-14
WO1996034623A1 (en) 1996-11-07
HK1016191A1 (en) 1999-10-29
AU710538B2 (en) 1999-09-23
ATE228851T1 (de) 2002-12-15
EP1233022B1 (en) 2015-12-09
EP0826001A1 (en) 1998-03-04
FR16C0015I2 (fr) 2017-06-09
WO1996034883A1 (en) 1996-11-07
CN1193324A (zh) 1998-09-16
ES2182971T3 (es) 2003-03-16

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