ES8303522A1 - Procedimiento para la mutacion doble de virus del genero herpes - Google Patents

Procedimiento para la mutacion doble de virus del genero herpes

Info

Publication number
ES8303522A1
ES8303522A1 ES502965A ES502965A ES8303522A1 ES 8303522 A1 ES8303522 A1 ES 8303522A1 ES 502965 A ES502965 A ES 502965A ES 502965 A ES502965 A ES 502965A ES 8303522 A1 ES8303522 A1 ES 8303522A1
Authority
ES
Spain
Prior art keywords
type
production
herpes simplex
simplex virus
new mutants
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES502965A
Other languages
English (en)
Other versions
ES502965A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ASTA-WERKE AKTIENGESELLSCHAFT CHEMISCHE FABRIK
Asta Medica GmbH
Original Assignee
ASTA-WERKE AKTIENGESELLSCHAFT CHEMISCHE FABRIK
Asta Werke AG Chemische Fabrik
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ASTA-WERKE AKTIENGESELLSCHAFT CHEMISCHE FABRIK, Asta Werke AG Chemische Fabrik filed Critical ASTA-WERKE AKTIENGESELLSCHAFT CHEMISCHE FABRIK
Publication of ES502965A0 publication Critical patent/ES502965A0/es
Publication of ES8303522A1 publication Critical patent/ES8303522A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/245—Herpetoviridae, e.g. herpes simplex virus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16634—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16661—Methods of inactivation or attenuation
    • C12N2710/16663—Methods of inactivation or attenuation by chemical treatment

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

PROCEDIMIENTO PARA LA MUTACION DOBLE DE VIRUS DEL GENERO HERPES. CONSISTE EN CULTIVAR VIRUS TIPO 1 DE HERPES SIMPLEX O VIRUS TIPOS 2 DE HERPES SIMPLEX EN CULTIVOS CELULARES A UNA TEMPERATURA ENTRE 20 C Y 40 C EN DOS ETAPAS, PRIMERO EN PRESENCIA DE ACIDO FOSFONOFORMICO, EN CONCENTRACION DE 20 A 50 NG/ML, Y POSTERIORMENTE EN PRESENCIA DE 5-ETIL-2''-DESOXIURIDINA, EN CONCENTRACION DE 5 A 20 NG/ML, O VICEVERSA, HACIENDOLES PASAR EN AMBOS CASOS A TRAVES DE VARIAS PASADAS. TIENE APLICACION PARA LA OBTENCION DE VACUNAS CONTRA EL HERPES.
ES502965A 1980-06-12 1981-06-11 Procedimiento para la mutacion doble de virus del genero herpes Expired ES8303522A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8019308 1980-06-12

Publications (2)

Publication Number Publication Date
ES502965A0 ES502965A0 (es) 1983-02-01
ES8303522A1 true ES8303522A1 (es) 1983-02-01

Family

ID=10514018

Family Applications (1)

Application Number Title Priority Date Filing Date
ES502965A Expired ES8303522A1 (es) 1980-06-12 1981-06-11 Procedimiento para la mutacion doble de virus del genero herpes

Country Status (7)

Country Link
US (1) US4322404A (es)
BE (1) BE889182A (es)
DE (1) DE3122669A1 (es)
ES (1) ES8303522A1 (es)
FR (1) FR2484446A1 (es)
IT (1) IT8148649A0 (es)
NL (1) NL8102827A (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4554159A (en) * 1981-11-12 1985-11-19 Institute Merieux Vaccine and method of immunizing against herpes simplex virus (types 1 and 2)
GB8305323D0 (en) * 1983-02-25 1983-03-30 Baylor College Medicine Infectious bovine rhinotracheitis vaccine
NL8303501A (nl) * 1983-10-12 1985-05-01 Centraal Diergeneeskundig Inst Deletiemutant van een herpesvirus en vaccin, dat dit virus bevat.
USRE33772E (en) * 1983-10-12 1991-12-17 Centraal Diergeneeskundig Instituut Deletion mutant of a herpesvirus and vaccine containing said virus
US4820514A (en) * 1985-12-30 1989-04-11 Texas A&M University System Low dosage of interferon to enhance vaccine efficiency
US5585096A (en) * 1994-06-23 1996-12-17 Georgetown University Replication-competent herpes simplex virus mediates destruction of neoplastic cells
US5837262A (en) * 1994-07-27 1998-11-17 Bio-Virus Research Incorporated Pharmaceutical compositions against several herpes virus infections and/or atherosclerotic plaque
US6471965B1 (en) * 1994-07-27 2002-10-29 Bio-Virus Research Incorporated Vaccine containing whole killed herpes viruses to prevent development of atherosclerotic plaque
AU2003249990B2 (en) * 2002-07-09 2007-06-28 Takeda Pharmaceutical Company Limited Animal protein free media for cultivation of cells

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR216081A1 (es) * 1976-07-02 1979-11-30 Dso Pharmachim Un metodo de preparar un mutante virosico avirulento a partir del virus de aujeszky
DE2714665A1 (de) * 1977-04-01 1978-10-05 Mayr Anton Praeparat zur behandlung von herpes zoster und anderen herpes-infektionen, sowie verfahren zu seiner herstellung

Also Published As

Publication number Publication date
DE3122669A1 (de) 1982-02-11
US4322404A (en) 1982-03-30
ES502965A0 (es) 1983-02-01
NL8102827A (nl) 1982-01-04
BE889182A (fr) 1981-12-11
FR2484446A1 (fr) 1981-12-18
IT8148649A0 (it) 1981-06-10

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