BR9201624A - Composto,processo para sua preparacao e composicao farmaceutica - Google Patents
Composto,processo para sua preparacao e composicao farmaceuticaInfo
- Publication number
- BR9201624A BR9201624A BR929201624A BR9201624A BR9201624A BR 9201624 A BR9201624 A BR 9201624A BR 929201624 A BR929201624 A BR 929201624A BR 9201624 A BR9201624 A BR 9201624A BR 9201624 A BR9201624 A BR 9201624A
- Authority
- BR
- Brazil
- Prior art keywords
- aryl
- lower alkyl
- cycloalkyl
- opt
- heteroaryl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB919109475A GB9109475D0 (en) | 1991-05-02 | 1991-05-02 | Piperazine derivatives |
GB919127189A GB9127189D0 (en) | 1991-12-21 | 1991-12-21 | Piperazine derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9201624A true BR9201624A (pt) | 1992-12-15 |
Family
ID=26298819
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR929201624A BR9201624A (pt) | 1991-05-02 | 1992-04-30 | Composto,processo para sua preparacao e composicao farmaceutica |
Country Status (24)
Country | Link |
---|---|
US (1) | US6127357A (pt) |
EP (1) | EP0512755B1 (pt) |
JP (1) | JP3095521B2 (pt) |
KR (1) | KR100203254B1 (pt) |
CN (2) | CN1040106C (pt) |
AT (1) | ATE115566T1 (pt) |
AU (1) | AU645681B2 (pt) |
BR (1) | BR9201624A (pt) |
CA (1) | CA2067929C (pt) |
CZ (1) | CZ286778B6 (pt) |
DE (1) | DE69200893T2 (pt) |
DK (1) | DK0512755T3 (pt) |
ES (1) | ES2065133T3 (pt) |
FI (1) | FI108720B (pt) |
GB (1) | GB2255337B (pt) |
HK (1) | HK1003001A1 (pt) |
HU (2) | HU223527B1 (pt) |
IE (1) | IE64634B1 (pt) |
IL (1) | IL101722A (pt) |
MX (1) | MX9201991A (pt) |
MY (1) | MY107756A (pt) |
RU (1) | RU2193561C2 (pt) |
SK (1) | SK280133B6 (pt) |
UA (1) | UA39917C2 (pt) |
Families Citing this family (100)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL101722A (en) * | 1991-05-02 | 1996-05-14 | Wyeth John & Brother Ltd | History of piperazine, their preparation and pharmaceutical preparations containing them |
GB9223153D0 (en) * | 1992-11-05 | 1992-12-16 | Wyeth John & Brother Ltd | Piperazine derivatives |
GB9300195D0 (en) * | 1993-01-06 | 1993-03-03 | Wyeth John & Brother Ltd | Piperazine derivatives |
GB9302622D0 (en) * | 1993-02-10 | 1993-03-24 | Wellcome Found | Heteroaromatic compounds |
GB9303968D0 (en) * | 1993-02-26 | 1993-04-14 | Wyeth John & Brother Ltd | 5-ht1a ligands |
GB9305672D0 (en) * | 1993-03-19 | 1993-05-05 | Wyeth John & Brother Ltd | Amide derivatives |
GB9306103D0 (en) * | 1993-03-24 | 1993-05-12 | Wyeth John & Brother Ltd | Piperazine derivatives |
FR2707294B1 (fr) * | 1993-07-06 | 1995-09-29 | Pf Medicament | Nouveaux dérivés de la 3,5-dioxo-(2H,4H)-1,2,4-triazine, leur préparation et leur application en thérapeutique humaine. |
GB9314758D0 (en) * | 1993-07-16 | 1993-08-25 | Wyeth John & Brother Ltd | Heterocyclic derivatives |
US5609849A (en) * | 1994-03-11 | 1997-03-11 | The Trustees Of The University Of Pennsylvania | Serotonin (5-HT1A) receptor ligands and imaging agents |
WO1995033725A1 (en) * | 1994-06-03 | 1995-12-14 | John Wyeth & Brother Limited | Novel processes and intermediates for the preparation of piperazine derivatives |
GB9411099D0 (en) * | 1994-06-03 | 1994-07-27 | Wyeth John & Brother Ltd | Piperazine derivatives |
DE4425146A1 (de) * | 1994-07-15 | 1996-01-18 | Basf Ag | Verwendung heterocyclischer Verbindungen |
US6231833B1 (en) | 1999-08-05 | 2001-05-15 | Pfizer Inc | 2,7-substituted octahydro-1H-pyrido[1,2-A]pyrazine derivatives as ligands for serotonin receptors |
EP0714663A3 (en) | 1994-11-28 | 1997-01-15 | Lilly Co Eli | Potentiation of drug responses by serotonin 1A receptor antagonists |
FR2727682A1 (fr) * | 1994-12-02 | 1996-06-07 | Pf Medicament | Nouveaux derives de 3,5-dioxo-(2h,4h)-1,2,4-triazines, leur preparation et leur application a titre de medicament |
US5541179A (en) * | 1995-05-02 | 1996-07-30 | American Home Products Corporation | Tropon-2-one piperazine carboxamides as serotonergic agents |
GB9514901D0 (en) * | 1995-07-20 | 1995-09-20 | American Home Prod | Piperazine derivatives |
DE69607904T2 (de) * | 1995-08-16 | 2000-10-05 | Lilly Co Eli | Potenzierung von Serotonin-Wirkstoffresponz |
GB9525239D0 (en) * | 1995-12-09 | 1996-02-07 | American Home Prod | Medical treatment |
IT1282705B1 (it) * | 1996-02-28 | 1998-03-31 | Recordati Chem Pharm | Uso di antagonisti del recettore serotoninergico 5-ht|a per il trattamento dell'incontinenza urinaria |
US5990114A (en) * | 1996-02-28 | 1999-11-23 | Recordati, S.A., Chemical And Pharmaceutical Company | Use of 5-HT1A receptor antagonists for the treatment of urinary incontinence |
DE19615232A1 (de) * | 1996-04-18 | 1997-10-23 | Merck Patent Gmbh | Neue Carbamoylderivate und deren Verwendung als 5-HT ¶1¶¶A¶-Antagonisten |
FR2753968B1 (fr) * | 1996-09-27 | 1998-11-27 | Sod Conseils Rech Applic | Nouvelles heteroaryloxyethylamines, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant |
FR2756283A1 (fr) * | 1996-11-27 | 1998-05-29 | Pf Medicament | Amines aromatiques d'arylpiperazines, leur preparation et leurs applications comme medicaments |
NZ337183A (en) * | 1997-03-04 | 2001-05-25 | Neurogen Corp | 1-(isoquinolin-1-yl)-4-(1-phenylmethyl)piperazines; dopamine receptor subtype specific ligands useful for the treatment of psychotic disorders |
US6008352A (en) * | 1997-04-03 | 1999-12-28 | Neurogen Corporation | 1-(isoquinolin-1-yl)-4-(1-phenylmethyl) piperazines; dopamine receptor subtype specific ligands |
CA2293480A1 (en) * | 1997-06-13 | 1998-12-17 | Neurogen Corporation | 2-aminoalkylaminoquinolines as dopamine d4 ligands |
US6313141B1 (en) | 1997-06-13 | 2001-11-06 | Neurogen Corporation | 2-aminoalkylaminoquinolines as dopamine D4 ligands |
US5972945A (en) * | 1997-06-13 | 1999-10-26 | Neurogen Corporation | 2-aminoalkylaminoquinolines; dopamine receptor subtype specific ligands |
US6399614B1 (en) | 1997-08-01 | 2002-06-04 | Recordati S.A. Chemical And Pharmaceutical Company | 1-(N-phenylaminoalkyl)piperazine derivatives substituted at position 2 of the phenyl ring |
AU9256498A (en) * | 1997-08-01 | 1999-02-22 | Recordati S.A. Chemical And Pharmaceutical Company | 1,4-disubstituted piperazines |
IT1293804B1 (it) | 1997-08-01 | 1999-03-10 | Recordati Chem Pharm | Diarilalchilpiperazine attive sulle basse vie urinarie |
US6271234B1 (en) * | 1997-08-01 | 2001-08-07 | Recordati S.A., Chemical And Pharmaceutical Company | 1,4-disubstituted piperazines |
EP0900792B1 (en) * | 1997-09-02 | 2003-10-29 | Duphar International Research B.V | Piperazine and piperidine derivatives as 5-HT1A and dopamine D2-receptor (ant)agonists |
DE69819266T2 (de) | 1997-09-02 | 2004-07-29 | Duphar International Research B.V. | Piperidin- und Piperazin Derivate als 5-HT1-Rezeptor-Agonisten |
UA66370C2 (en) | 1997-12-16 | 2004-05-17 | Lilly Co Eli | Arylpiperazines having activity to setotonin 1 receptors |
US6281216B1 (en) * | 1998-02-09 | 2001-08-28 | Duphar International Research B.V. | 2-aminoquinoline derivatives having d4-agonistic activity |
US6376494B1 (en) | 1998-06-15 | 2002-04-23 | American Home Products Corporation | Cycloalkyl-substituted aryl-piperazines, piperidines and tetrahydropyridines as serotonergic agents |
CA2334254A1 (en) * | 1998-06-15 | 1999-12-23 | American Home Products Corporation | Cycloalkyl-substituted aryl-piperazines, piperidines and tetrahydropyridines as serotonergic agents |
US6344458B1 (en) | 1998-12-17 | 2002-02-05 | American Home Products Corporation | Piperazine ethylamide derivatives |
CA2351860A1 (en) * | 1998-12-17 | 2000-06-22 | Wyeth | Piperazine ethylamide derivatives with 5-ht1a receptor activity |
AU1468001A (en) | 1999-11-12 | 2001-06-06 | Wyeth | Branched adamantyl and noradamantyl aryl- and aralkylpiperazines with serotonin 5-HT1a activity |
US6831084B1 (en) | 1999-11-12 | 2004-12-14 | Wyeth | Branched adamantyl and noradamantyl aryl- and aralkylpiperazines with serotonin 5-HT1A activity |
KR100333500B1 (ko) * | 2000-01-19 | 2002-04-25 | 박호군 | 아릴피페라진 화합물 및 그의 제조방법 |
US6613901B2 (en) | 2000-03-08 | 2003-09-02 | Neurogen Corporation | 2-aminoalkylaminoquinolines as dopamine D4 ligands |
US20060287335A1 (en) | 2000-11-28 | 2006-12-21 | Wyeth | Serotonergic agents for treating sexual dysfunction |
US20060223824A1 (en) | 2000-11-28 | 2006-10-05 | Wyeth | Serotonergic agents |
US6469007B2 (en) | 2000-11-28 | 2002-10-22 | Wyeth | Serotonergic agents |
DE60231507D1 (de) | 2001-07-20 | 2010-07-01 | Psychogenics Inc | Behandlung von hyperaktivitätsstörungen und aufmerksamkeitsdefiziten |
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DE60328756D1 (de) * | 2002-03-12 | 2009-09-24 | Wyeth Corp | Verfahren zur herstellung von chiralen n-aryl piperazinen |
US7091349B2 (en) | 2002-03-12 | 2006-08-15 | Wyeth | Process for synthesizing N-aryl piperazines with chiral N′-1-[benzoyl(2-pyridyl)amino]-2-propane substitution |
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WO2003099266A2 (en) | 2002-05-23 | 2003-12-04 | Abbott Laboratories | Acetamides and benzamides that are useful in treating sexual dysfunction |
JP2006503106A (ja) * | 2002-09-17 | 2006-01-26 | ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー | 統合失調症を処置するためのヘテロ環式置換ピペラジン |
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US7731940B2 (en) | 2006-01-25 | 2010-06-08 | The Regents Of The University Of California | Compositions and methods related to serotonin 5-HT1A receptors |
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TW200901974A (en) | 2007-01-16 | 2009-01-16 | Wyeth Corp | Compounds, compositions, and methods of making and using them |
EP2963028B1 (en) | 2009-05-27 | 2018-08-01 | Atir Holding S.A. | Piperazine derivatives and their pharmaceutical use |
RS56352B2 (sr) | 2009-06-25 | 2023-02-28 | Alkermes Pharma Ireland Ltd | Heterociklična jedinjenja za lečenje neuroloških i psiholoških poremećaja |
CA2766033C (en) * | 2009-06-25 | 2016-09-20 | Alkermes, Inc. | Prodrugs of nh-acidic compounds |
AU2011270701B2 (en) | 2010-06-24 | 2015-05-14 | Alkermes Pharma Ireland Limited | Prodrugs of NH-acidic compounds: ester, carbonate, carbamate and phosphonate derivatives |
SI2685979T1 (sl) | 2011-03-18 | 2017-04-26 | Alkermes Pharma Ireland Limited | Injekcijski farmacevtski sestavki, ki obsegajo vodotopni antipsihotik, sorbitan lavrat in polisorbat 20 |
GB201112987D0 (en) * | 2011-07-28 | 2011-09-14 | Ge Healthcare Ltd | Novel compound |
CA2858787C (en) | 2011-12-15 | 2017-11-21 | Alkermes Pharma Ireland Limited | Prodrugs of tertiary amine compounds |
NZ630643A (en) | 2012-03-19 | 2017-08-25 | Alkermes Pharma Ireland Ltd | Pharmaceutical compositions comprising fatty acid esters |
JP6219918B2 (ja) | 2012-03-19 | 2017-10-25 | アルカームス ファーマ アイルランド リミテッド | グリセロールエステルを含む医薬組成物 |
CA2867137C (en) | 2012-03-19 | 2020-12-08 | Alkermes Pharma Ireland Limited | Pharmaceutical compositions comprising aripiprazole prodrugs and benzyl alcohol |
JP6654042B2 (ja) | 2012-09-19 | 2020-02-26 | アルカームス ファーマ アイルランド リミテッド | 貯蔵安定性が改善された医薬組成物 |
CN103864761B (zh) * | 2014-03-12 | 2016-01-20 | 天津药物研究院有限公司 | 一种含吡啶的哌嗪类衍生物及其制备方法和用途 |
MX2016012041A (es) | 2014-03-20 | 2017-01-19 | Alkermes Pharma Ireland Ltd | Formulaciones de aripiprazol que tienen mayores velocidades de inyeccion. |
KR101556571B1 (ko) | 2014-03-31 | 2015-10-01 | (주)월드트렌드 | 장식용 보석을 체결할 수 있는 안경 |
EA201790806A1 (ru) | 2014-11-05 | 2017-11-30 | Флексус Байосайенсиз, Инк. | Иммунорегулирующие средства |
UY36390A (es) * | 2014-11-05 | 2016-06-01 | Flexus Biosciences Inc | Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido), sus métodos de síntesis y composiciones farmacéuticas que los contienen |
MA41168A (fr) * | 2014-12-17 | 2017-10-24 | Acraf | Nouveaux composés antibactériens |
CN109415373A (zh) * | 2016-06-08 | 2019-03-01 | 方济各安吉利克化学联合股份有限公司 | 新的抗菌化合物 |
CA3092335A1 (en) | 2018-03-05 | 2019-09-12 | Alkermes Pharma Ireland Limited | Aripiprazole dosing strategy |
KR20210076226A (ko) | 2019-12-13 | 2021-06-24 | 주식회사 에피바이오텍 | 피페라진 유도체를 포함하는 탈모의 예방 또는 치료용 조성물 |
WO2023144764A1 (en) | 2022-01-29 | 2023-08-03 | Suven Life Sciences Limited | Benzoisothiazole and benzoisoxazole compounds for the treatment of mental disorders |
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NZ231631A (en) * | 1988-12-08 | 1992-07-28 | Duphar Int Res | Heterocyclically-substituted piperazine and diazepine derivatives and anxiolytic compositions |
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GB9411099D0 (en) * | 1994-06-03 | 1994-07-27 | Wyeth John & Brother Ltd | Piperazine derivatives |
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1992
- 1992-04-29 IL IL10172292A patent/IL101722A/en active IP Right Grant
- 1992-04-29 AU AU15241/92A patent/AU645681B2/en not_active Ceased
- 1992-04-29 MX MX9201991A patent/MX9201991A/es active IP Right Grant
- 1992-04-30 FI FI921942A patent/FI108720B/fi active
- 1992-04-30 DE DE69200893T patent/DE69200893T2/de not_active Expired - Lifetime
- 1992-04-30 RU SU5011552/04A patent/RU2193561C2/ru active
- 1992-04-30 AT AT92303918T patent/ATE115566T1/de not_active IP Right Cessation
- 1992-04-30 HU HU9201462A patent/HU223527B1/hu not_active IP Right Cessation
- 1992-04-30 BR BR929201624A patent/BR9201624A/pt not_active Application Discontinuation
- 1992-04-30 GB GB9209340A patent/GB2255337B/en not_active Expired - Fee Related
- 1992-04-30 MY MYPI92000746A patent/MY107756A/en unknown
- 1992-04-30 EP EP92303918A patent/EP0512755B1/en not_active Expired - Lifetime
- 1992-04-30 DK DK92303918.4T patent/DK0512755T3/da active
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- 1992-05-01 JP JP04112527A patent/JP3095521B2/ja not_active Expired - Fee Related
- 1992-05-01 CA CA002067929A patent/CA2067929C/en not_active Expired - Lifetime
- 1992-05-02 KR KR1019920007528A patent/KR100203254B1/ko not_active IP Right Cessation
- 1992-05-02 CN CN92103153A patent/CN1040106C/zh not_active Expired - Fee Related
- 1992-05-04 SK SK1344-92A patent/SK280133B6/sk not_active IP Right Cessation
- 1992-05-04 CZ CS19921344A patent/CZ286778B6/cs not_active IP Right Cessation
- 1992-07-01 IE IE921409A patent/IE64634B1/en not_active IP Right Cessation
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1993
- 1993-06-15 UA UA93002895A patent/UA39917C2/uk unknown
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1995
- 1995-05-11 US US08/438,812 patent/US6127357A/en not_active Expired - Fee Related
- 1995-06-22 HU HU95P/P00338P patent/HU211148A9/hu unknown
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1996
- 1996-12-06 CN CN96118586A patent/CN1084619C/zh not_active Expired - Fee Related
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1998
- 1998-03-12 HK HK98102076A patent/HK1003001A1/xx not_active IP Right Cessation
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