BR112023026862A2 - Compostos de oligonucleotídeos anti-flt1 otimizados para tratamento de pré-eclâmpsia e outros distúrbios angiogênicos - Google Patents

Compostos de oligonucleotídeos anti-flt1 otimizados para tratamento de pré-eclâmpsia e outros distúrbios angiogênicos

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Publication number
BR112023026862A2
BR112023026862A2 BR112023026862A BR112023026862A BR112023026862A2 BR 112023026862 A2 BR112023026862 A2 BR 112023026862A2 BR 112023026862 A BR112023026862 A BR 112023026862A BR 112023026862 A BR112023026862 A BR 112023026862A BR 112023026862 A2 BR112023026862 A2 BR 112023026862A2
Authority
BR
Brazil
Prior art keywords
treatment
angiogenic disorders
flt1
eclampsia
oligonucleotide compounds
Prior art date
Application number
BR112023026862A
Other languages
English (en)
Portuguese (pt)
Inventor
Ananth Karumanchi
Anastasia Khvorova
Annabelle Biscans
Sarah Davis
Narayan Hariharan Vignesh
Original Assignee
Beth Israel Deaconess Medical Ct Inc
Univ Massachusetts
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beth Israel Deaconess Medical Ct Inc, Univ Massachusetts filed Critical Beth Israel Deaconess Medical Ct Inc
Publication of BR112023026862A2 publication Critical patent/BR112023026862A2/pt

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N2310/3533—Halogen
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    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/32—Special delivery means, e.g. tissue-specific

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  • Veterinary Medicine (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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  • Saccharide Compounds (AREA)
BR112023026862A 2021-06-23 2022-06-22 Compostos de oligonucleotídeos anti-flt1 otimizados para tratamento de pré-eclâmpsia e outros distúrbios angiogênicos BR112023026862A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202163214224P 2021-06-23 2021-06-23
PCT/US2022/034461 WO2022271786A1 (en) 2021-06-23 2022-06-22 Optimized anti-flt1 oligonucleotide compounds for treatment of preeclampsia and other angiogenic disorders

Publications (1)

Publication Number Publication Date
BR112023026862A2 true BR112023026862A2 (pt) 2024-03-05

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BR112023026862A BR112023026862A2 (pt) 2021-06-23 2022-06-22 Compostos de oligonucleotídeos anti-flt1 otimizados para tratamento de pré-eclâmpsia e outros distúrbios angiogênicos

Country Status (13)

Country Link
US (2) US11702659B2 (https=)
EP (1) EP4359539A4 (https=)
JP (2) JP7758907B2 (https=)
KR (1) KR20240040729A (https=)
CN (1) CN117677699A (https=)
AR (1) AR126207A1 (https=)
AU (1) AU2022299169A1 (https=)
BR (1) BR112023026862A2 (https=)
CA (1) CA3174095A1 (https=)
IL (1) IL309334A (https=)
MX (1) MX2023015523A (https=)
TW (1) TW202315943A (https=)
WO (1) WO2022271786A1 (https=)

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CA3033368A1 (en) * 2016-08-12 2018-02-15 University Of Massachusetts Conjugated oligonucleotides
JP7406793B2 (ja) 2017-06-23 2023-12-28 ユニバーシティー オブ マサチューセッツ ２テイル自己デリバリー型ｓｉＲＮＡおよび関連方法
JP7627042B2 (ja) 2018-08-23 2025-02-05 ユニバーシティー オブ マサチューセッツ Ｏ－メチルリッチ完全安定化オリゴヌクレオチド
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