BR112023022116A2 - Uma forma em estado sólido de tafamidis e um processo para sua preparação - Google Patents

Uma forma em estado sólido de tafamidis e um processo para sua preparação

Info

Publication number
BR112023022116A2
BR112023022116A2 BR112023022116A BR112023022116A BR112023022116A2 BR 112023022116 A2 BR112023022116 A2 BR 112023022116A2 BR 112023022116 A BR112023022116 A BR 112023022116A BR 112023022116 A BR112023022116 A BR 112023022116A BR 112023022116 A2 BR112023022116 A2 BR 112023022116A2
Authority
BR
Brazil
Prior art keywords
preparation
tafamidis
solid state
state form
crystalline
Prior art date
Application number
BR112023022116A
Other languages
English (en)
Portuguese (pt)
Inventor
Daniele Pengo
Giuseppe Barreca
Liming Huang
Luca Carcone
Massimo Zampieri
Piero Paravidino
Original Assignee
Quim Sintetica S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Quim Sintetica S A filed Critical Quim Sintetica S A
Publication of BR112023022116A2 publication Critical patent/BR112023022116A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D263/57—Aryl or substituted aryl radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicinal Preparation (AREA)
BR112023022116A 2021-04-26 2022-04-22 Uma forma em estado sólido de tafamidis e um processo para sua preparação BR112023022116A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP21382362.8A EP4083027A1 (en) 2021-04-26 2021-04-26 A solid state form of tafamidis and a process for its preparation
PCT/EP2022/060716 WO2022229026A1 (en) 2021-04-26 2022-04-22 A solid state form of tafamidis and a process for its preparation

Publications (1)

Publication Number Publication Date
BR112023022116A2 true BR112023022116A2 (pt) 2024-01-09

Family

ID=75746555

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112023022116A BR112023022116A2 (pt) 2021-04-26 2022-04-22 Uma forma em estado sólido de tafamidis e um processo para sua preparação

Country Status (8)

Country Link
US (1) US20240208915A1 (https=)
EP (2) EP4083027A1 (https=)
JP (1) JP2024515770A (https=)
CN (1) CN117255781A (https=)
BR (1) BR112023022116A2 (https=)
CA (1) CA3216325A1 (https=)
MX (1) MX2023012460A (https=)
WO (1) WO2022229026A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20250042864A1 (en) * 2021-11-17 2025-02-06 Teva Pharmaceuticals International Gmbh Solid state form of tafamidis

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2800237C (en) 2002-12-19 2016-05-17 The Scripps Research Institute Compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding
RU2565066C2 (ru) * 2010-04-21 2015-10-20 КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. Производные 1-(2-фторбифенил-4-ил)-алкилкарбоновой кислоты для лечения транстиретинового амилоидоза
RU2586330C2 (ru) 2011-09-16 2016-06-10 Пфайзер Инк. Твердые формы ингибитора диссоциации транстиретина
PT4349406T (pt) 2014-09-08 2026-02-04 Pfizer Formas sólidas cristalinas de 6-carboxi-2-(3,5-diclorofenil)-benzoxazol para utilização como medicamento
GB2571950A (en) 2018-03-13 2019-09-18 Azad Pharma Ag New polymorph and new path to synthesize tafamidis
EP3969443B1 (en) 2019-05-16 2024-11-20 Teva Pharmaceuticals International GmbH Solid state forms of tafamidis and salts thereof
US20220251052A1 (en) * 2019-07-04 2022-08-11 Msn Laboratories Private Limited, R&D Center Improved process for the preparation of 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid or its pharmaceutically acceptable salts and polymorphs thereof
WO2021019448A1 (en) 2019-08-01 2021-02-04 Honour (R&D) Process for the preparation of transthyretin dissociation inhibitor
WO2021152623A1 (en) * 2020-01-27 2021-08-05 Dr. Reddy’S Laboratories Limited Improved processes for the preparation of tafamidis and its meglumine salt
US12522573B2 (en) * 2020-10-19 2026-01-13 Alivus Life Sciences Limited Process for preparation of tafamidis and salts thereof

Also Published As

Publication number Publication date
US20240208915A1 (en) 2024-06-27
WO2022229026A1 (en) 2022-11-03
EP4083027A1 (en) 2022-11-02
CN117255781A (zh) 2023-12-19
EP4330237A1 (en) 2024-03-06
JP2024515770A (ja) 2024-04-10
MX2023012460A (es) 2023-12-14
CA3216325A1 (en) 2022-11-03

Similar Documents

Publication Publication Date Title
PE20211756A1 (es) FORMAS POLIMORFICAS NOVEDOSAS DE UN INHIBIDOR DE TGFß
BR112018000497A2 (pt) processo para preparação de um composto
BR112017017892A2 (pt) processo para produzir etanol.
RU2019126333A (ru) 19-нор нейроактивные стероиды и способы их применения
GT201300253A (es) Preparacion de gadobutrol de alta pureza
EA201990455A1 (ru) КОНДЕНСИРОВАННОЕ ТРИЦИКЛИЧЕСКОЕ ПРОИЗВОДНОЕ γ-АМИНОКИСЛОТЫ, СПОСОБ ЕГО ПОЛУЧЕНИЯ И ЕГО МЕДИЦИНСКОЕ ПРИМЕНЕНИЕ
BR112013026321A2 (pt) composto, tensoativo, produto formulado, e, processo para a preparação de betaína
MX2022015151A (es) Procesos para preparar acido 3-(3-(3,5-dimetil-1h-pirazol-4-il)pro poxi)-4- 5-fluorobenzoico (ag-10), sus compuestos intermedios, y sales del mismo.
CL2011000296A1 (es) Proceso de preparación del ester metílico del ácido 4-oxo-octahidro-indol-1-carboxílico y compuestos intermediarios utilizados.
CO2018010787A2 (es) Compuesto de griseofulvina
BR112012017845A2 (pt) novo processo para produção de derivados de benzofenona
MX2021007505A (es) Síntesis de 3-metil-1,2,4-tiadiazol-5-carbohidrazida o de su forma deuterada con metil-d3.
BR112023022116A2 (pt) Uma forma em estado sólido de tafamidis e um processo para sua preparação
AR118647A1 (es) Proceso de preparación de 2-(3,5-diclorofenil)-6-benzoxazolcarboxilato de 1-deoxi-1-metilamino-d-glucitol
BR112018014534A2 (pt) método e intermediário para a preparação de tulatromicina
IT201900025096A1 (it) Processo per la sintesi di acido 2,5-furandicarbossilico
WO2020132471A8 (en) Crystalline and salt forms of an organic compound and pharmaceutical compositions thereof
WO2020016847A3 (en) Purification process for preparation of eribulin and intermediates thereof
BR112015023343A2 (pt) método para preparar sovaprevir, método de preparar um composto da fórmula (c), método de preparação do composto f-2, composto, processo, método de preparação de uma forma amorfa pura de sovaprevir, e,forma cristalina de sovaprevir
BR112023000065A2 (pt) Sal e forma cristalina de composto de pirimidina e métodos de preparação para os mesmos
BR112021024039A2 (pt) Sínteses de furanos substituídos
EA202192581A1 (ru) Композиции d-метирозина и способы их получения
EA202191158A1 (ru) Новый способ получения n,n'-бис[2-(1н-имидазол-4-ил)этил]малонамида
PE20180453A1 (es) Derivados de acido (s)-2'-vinil-abscisico
BR112018010056A2 (pt) composto de fórmula v ou vi, métodos de prepração dos compostos de fórumla vi, v e iv, usos dos compostos de fórmulas vi, viiia, ixa, viiib e ixb e composto