BR112023021993A2 - Métodos de geração de células endoteliais da córnea madura - Google Patents
Métodos de geração de células endoteliais da córnea maduraInfo
- Publication number
- BR112023021993A2 BR112023021993A2 BR112023021993A BR112023021993A BR112023021993A2 BR 112023021993 A2 BR112023021993 A2 BR 112023021993A2 BR 112023021993 A BR112023021993 A BR 112023021993A BR 112023021993 A BR112023021993 A BR 112023021993A BR 112023021993 A2 BR112023021993 A2 BR 112023021993A2
- Authority
- BR
- Brazil
- Prior art keywords
- endothelial cells
- methods
- mature
- generating
- corneal endothelial
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 210000002889 endothelial cell Anatomy 0.000 title 1
- 210000000399 corneal endothelial cell Anatomy 0.000 abstract 3
- 102000040945 Transcription factor Human genes 0.000 abstract 1
- 108091023040 Transcription factor Proteins 0.000 abstract 1
- 230000003511 endothelial effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0621—Eye cells, e.g. cornea, iris pigmented cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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- C12N2500/00—Specific components of cell culture medium
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- C12N2500/00—Specific components of cell culture medium
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/113—Acidic fibroblast growth factor (aFGF, FGF-1)
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
- C12N2501/72—Transferases (EC 2.)
- C12N2501/727—Kinases (EC 2.7.)
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
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- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/50—Proteins
- C12N2533/52—Fibronectin; Laminin
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- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
- C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- General Engineering & Computer Science (AREA)
- Ophthalmology & Optometry (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biophysics (AREA)
- Developmental Biology & Embryology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Plant Pathology (AREA)
- Virology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
métodos de geração de células endoteliais da córnea madura. a presente invenção refere-se a métodos para gerar células endoteliais da córnea, por exemplo, células endoteliais da córnea maduras, aumentando a expressão de um fator de transcrição em progenitores endoteliais da córnea e composições dos mesmos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202163183562P | 2021-05-03 | 2021-05-03 | |
PCT/US2022/027335 WO2022235586A1 (en) | 2021-05-03 | 2022-05-02 | Methods of generating mature corneal endothelial cells |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112023021993A2 true BR112023021993A2 (pt) | 2024-02-20 |
Family
ID=81750591
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112023021993A BR112023021993A2 (pt) | 2021-05-03 | 2022-05-02 | Métodos de geração de células endoteliais da córnea madura |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP4334437A1 (pt) |
JP (1) | JP2024519218A (pt) |
KR (1) | KR20240005837A (pt) |
CN (1) | CN117242173A (pt) |
AU (1) | AU2022270611A1 (pt) |
BR (1) | BR112023021993A2 (pt) |
CA (1) | CA3216719A1 (pt) |
MX (1) | MX2023013079A (pt) |
TW (1) | TW202309274A (pt) |
WO (1) | WO2022235586A1 (pt) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2024092086A1 (en) * | 2022-10-26 | 2024-05-02 | The Trustees Of The University Of Pennsylvania | Compositions and methods for regenerating corneal endothelium |
WO2024128696A1 (ko) * | 2022-12-13 | 2024-06-20 | 재단법인 아산사회복지재단 | 줄기세포의 각막 내피 세포로의 분화 유도 방법 및 이의 용도 |
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-
2022
- 2022-05-02 AU AU2022270611A patent/AU2022270611A1/en active Pending
- 2022-05-02 CA CA3216719A patent/CA3216719A1/en active Pending
- 2022-05-02 JP JP2023568269A patent/JP2024519218A/ja active Pending
- 2022-05-02 KR KR1020237041521A patent/KR20240005837A/ko unknown
- 2022-05-02 CN CN202280032423.4A patent/CN117242173A/zh active Pending
- 2022-05-02 EP EP22725037.0A patent/EP4334437A1/en active Pending
- 2022-05-02 BR BR112023021993A patent/BR112023021993A2/pt unknown
- 2022-05-02 WO PCT/US2022/027335 patent/WO2022235586A1/en active Application Filing
- 2022-05-02 MX MX2023013079A patent/MX2023013079A/es unknown
- 2022-05-03 TW TW111116689A patent/TW202309274A/zh unknown
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AU2022270611A9 (en) | 2024-02-22 |
WO2022235586A1 (en) | 2022-11-10 |
AU2022270611A1 (en) | 2023-10-12 |
KR20240005837A (ko) | 2024-01-12 |
MX2023013079A (es) | 2023-11-16 |
JP2024519218A (ja) | 2024-05-09 |
TW202309274A (zh) | 2023-03-01 |
CA3216719A1 (en) | 2022-11-10 |
EP4334437A1 (en) | 2024-03-13 |
CN117242173A (zh) | 2023-12-15 |
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