BR112022024231A2 - Método de preparação de (4-isopropoxi-2-metil) fenil isopropil cetona - Google Patents

Método de preparação de (4-isopropoxi-2-metil) fenil isopropil cetona

Info

Publication number
BR112022024231A2
BR112022024231A2 BR112022024231A BR112022024231A BR112022024231A2 BR 112022024231 A2 BR112022024231 A2 BR 112022024231A2 BR 112022024231 A BR112022024231 A BR 112022024231A BR 112022024231 A BR112022024231 A BR 112022024231A BR 112022024231 A2 BR112022024231 A2 BR 112022024231A2
Authority
BR
Brazil
Prior art keywords
isopropoxy
methyl
product
preparation
isopropyl ketone
Prior art date
Application number
BR112022024231A
Other languages
English (en)
Inventor
Liu Wei
Wu Shaoxiang
Gao Rui
Wang Rui
Wang Wenjun
Original Assignee
Adama Makhteshim Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adama Makhteshim Ltd filed Critical Adama Makhteshim Ltd
Publication of BR112022024231A2 publication Critical patent/BR112022024231A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/004—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/53—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and hydroxy groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/54—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/584—Recycling of catalysts

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)

Abstract

MÉTODO DE PREPARAÇÃO DE (4-ISOPROPOXI-2-METIL)FENILISOPROPIL CETONA. A invenção refere-se a um método de preparação de (4-isopropoxi-2-metil) fenilisopropilcetona, particularmente o método de preparação inclui: reação de m-cresol com tiocianato na presença de um catalisador para obter um produto A; reação do produto A com haloisopropano na presença de uma base e um catalisador para obter um produto B; reação do produto B com haleto de isopropil magnésio e tratamento para obter (4-isopropoxi-2-metil) fenil isopropil cetona. A pureza da (4-isopropoxi-2-metil) fenil isopropil cetona preparada pelas etapas acima é superior a 99% e o rendimento total é superior a 79%. O método de acordo com a presente invenção evita o uso de reagentes tóxicos e a geração de uma grande quantidade de águas residuais ácidas, reduz a temperatura da reação e melhora o rendimento da reação. A rota do processo é simples e eficiente, e o custo é reduzido. A pureza do produto resultante é alta, a segurança da produção é bastante aprimorada e o método é fácil de industrializar.
BR112022024231A 2020-05-28 2021-05-24 Método de preparação de (4-isopropoxi-2-metil) fenil isopropil cetona BR112022024231A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN202010468817.7A CN111548257B (zh) 2020-05-28 2020-05-28 一种（4-异丙氧基-2-甲基）苯基异丙基酮的制备方法
PCT/CN2021/095446 WO2021238839A1 (zh) 2020-05-28 2021-05-24 一种(4-异丙氧基-2-甲基)苯基异丙基酮的制备方法

Publications (1)

Publication Number Publication Date
BR112022024231A2 true BR112022024231A2 (pt) 2023-01-31

Family

ID=72000988

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022024231A BR112022024231A2 (pt) 2020-05-28 2021-05-24 Método de preparação de (4-isopropoxi-2-metil) fenil isopropil cetona

Country Status (8)

Country Link
US (1) US20230212101A1 (pt)
EP (1) EP4159713A4 (pt)
JP (1) JP2023527071A (pt)
KR (1) KR20230019141A (pt)
CN (1) CN111548257B (pt)
BR (1) BR112022024231A2 (pt)
IL (1) IL298598A (pt)
WO (1) WO2021238839A1 (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111548257B (zh) * 2020-05-28 2022-11-15 安道麦马克西姆有限公司 一种（4-异丙氧基-2-甲基）苯基异丙基酮的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI366438B (en) * 2004-08-12 2012-06-21 Ishihara Sangyo Kaisha Fungicidal composition containing acid amide derivative
US8791100B2 (en) * 2010-02-02 2014-07-29 Novartis Ag Aryl benzylamine compounds
JP2016108332A (ja) * 2014-12-08 2016-06-20 石原産業株式会社 アミノ化合物の製造方法
CN117466803A (zh) * 2017-08-21 2024-01-30 阿卡蒂亚药品公司 化合物、其盐和用于治疗疾病的方法
CN111548257B (zh) * 2020-05-28 2022-11-15 安道麦马克西姆有限公司 一种（4-异丙氧基-2-甲基）苯基异丙基酮的制备方法

Also Published As

Publication number Publication date
KR20230019141A (ko) 2023-02-07
EP4159713A1 (en) 2023-04-05
IL298598A (en) 2023-01-01
EP4159713A4 (en) 2024-07-03
WO2021238839A1 (zh) 2021-12-02
JP2023527071A (ja) 2023-06-26
CN111548257A (zh) 2020-08-18
US20230212101A1 (en) 2023-07-06
CN111548257B (zh) 2022-11-15

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