BR112022000619A2 - Derivados de benzotiofeno, tienopiridina e tienopirimidina para a modulação de sting - Google Patents

Derivados de benzotiofeno, tienopiridina e tienopirimidina para a modulação de sting

Info

Publication number
BR112022000619A2
BR112022000619A2 BR112022000619A BR112022000619A BR112022000619A2 BR 112022000619 A2 BR112022000619 A2 BR 112022000619A2 BR 112022000619 A BR112022000619 A BR 112022000619A BR 112022000619 A BR112022000619 A BR 112022000619A BR 112022000619 A2 BR112022000619 A2 BR 112022000619A2
Authority
BR
Brazil
Prior art keywords
thienopyridine
benzothiophene
thienopyrimidine derivatives
sting
modulation
Prior art date
Application number
BR112022000619A
Other languages
English (en)
Inventor
Nicholas Cuzzupe Anthony
Joseph Morrow Benjamin
Grant Hubert Jonathan
Lloyd Dennis Matthew
Anthony Stupple Paul
Original Assignee
Ctxt Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ctxt Pty Ltd filed Critical Ctxt Pty Ltd
Publication of BR112022000619A2 publication Critical patent/BR112022000619A2/pt

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

derivados de benzotiofeno, tienopiridina e tienopirimidina para a modulação de sting. trata-se de um composto de fórmula i: (i); em que: w é o ou nh; a1 é cra ou n; a2 é crb ou n; a3 é crc ou n; a4 é crd ou n; em que não mais que dois dentre a1, a2, a3, e a4 podem ser n; um ou dois dentre ra, rb, rc e rd, (se presente) são selecionados dentre h, f, cl, br, me, cf3, ciclopropila, ciano, ome, oet, ch2oh, ch2ome e oh; o restante de ra, rb, rc e rd, (se presente) é h; rn1 é h ou me; um dentre rc2 e rc3 é c(=o)nh2; o outro é selecionado dentre h, cl, f, br, me, ome, oet, ciano, cf3, ch2oh, ch2ome, c2 4 alquenila e c5heterociclila; rc1 e rc4 são independentemente selecionados dentre h, cl, f, br, me, ome, oet, ciano, cf3, ch2oh, ch2ome, c2 4 alquenila e c5heterociclila.
BR112022000619A 2019-07-18 2020-07-17 Derivados de benzotiofeno, tienopiridina e tienopirimidina para a modulação de sting BR112022000619A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1910304.3A GB201910304D0 (en) 2019-07-18 2019-07-18 Compounds
PCT/EP2020/070326 WO2021009362A1 (en) 2019-07-18 2020-07-17 Benzothiophene, thienopyridine and thienopyrimidine derivatives for the modulation of sting

Publications (1)

Publication Number Publication Date
BR112022000619A2 true BR112022000619A2 (pt) 2022-03-03

Family

ID=67839823

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022000619A BR112022000619A2 (pt) 2019-07-18 2020-07-17 Derivados de benzotiofeno, tienopiridina e tienopirimidina para a modulação de sting

Country Status (10)

Country Link
US (1) US20220380354A1 (pt)
EP (1) EP3999184B1 (pt)
JP (1) JP2022541043A (pt)
CN (1) CN114206880A (pt)
AU (1) AU2020312745A1 (pt)
BR (1) BR112022000619A2 (pt)
CA (1) CA3147538A1 (pt)
ES (1) ES2966333T3 (pt)
GB (1) GB201910304D0 (pt)
WO (1) WO2021009362A1 (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202200136A (zh) 2020-04-10 2022-01-01 日商小野藥品工業股份有限公司 癌治療方法

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Also Published As

Publication number Publication date
US20220380354A1 (en) 2022-12-01
AU2020312745A1 (en) 2022-02-17
JP2022541043A (ja) 2022-09-21
CN114206880A (zh) 2022-03-18
EP3999184B1 (en) 2023-09-20
CA3147538A1 (en) 2021-01-21
GB201910304D0 (en) 2019-09-04
WO2021009362A1 (en) 2021-01-21
EP3999184A1 (en) 2022-05-25
ES2966333T3 (es) 2024-04-22

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