BR112021024822A2 - Terapia de combinação de terapia citotóxica mediada por células e inibidor de proteína da família bcl2 pró-sobrevivência - Google Patents

Terapia de combinação de terapia citotóxica mediada por células e inibidor de proteína da família bcl2 pró-sobrevivência

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Publication number
BR112021024822A2
BR112021024822A2 BR112021024822A BR112021024822A BR112021024822A2 BR 112021024822 A2 BR112021024822 A2 BR 112021024822A2 BR 112021024822 A BR112021024822 A BR 112021024822A BR 112021024822 A BR112021024822 A BR 112021024822A BR 112021024822 A2 BR112021024822 A2 BR 112021024822A2
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BR
Brazil
Prior art keywords
therapy
cell
pro
family protein
bcl2 family
Prior art date
Application number
BR112021024822A
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English (en)
Inventor
Archana Brahmandam
Paul Thomas Evan
Jason Dubovsky
Michael Ports
Ronald Dubowy
Rupesh Amin
Original Assignee
Juno Therapeutics Inc
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Publication date
Application filed by Juno Therapeutics Inc filed Critical Juno Therapeutics Inc
Publication of BR112021024822A2 publication Critical patent/BR112021024822A2/pt

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    • C12N5/0602—Vertebrate cells
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    • C12N5/0636—T lymphocytes
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    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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Abstract

terapia de combinação de terapia citotóxica mediada por células e inibidor de proteína da família bcl2 pró-sobrevivência. a presente invenção refere-se a métodos, usos e artigos de fabricação de terapias de combinação envolvendo imunoterapias e terapias celulares, tais como terapia celular adotiva, por exemplo, uma terapia com células t e o uso de um inibidor de uma proteína da família bcl2 pró-sobrevivência, por exemplo, um inibidor de bcl2, para o tratamento de indivíduos com ou suspeitos de ter um câncer, e métodos, usos e artigos de fabricação relacionados. a terapia com células t inclui células expressando receptores recombinantes, como receptores de antígenos quiméricos (cars).
BR112021024822A 2019-06-12 2020-06-11 Terapia de combinação de terapia citotóxica mediada por células e inibidor de proteína da família bcl2 pró-sobrevivência BR112021024822A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962860748P 2019-06-12 2019-06-12
US201962890594P 2019-08-22 2019-08-22
PCT/US2020/037333 WO2020252218A1 (en) 2019-06-12 2020-06-11 Combination therapy of a cell-mediated cytotoxic therapy and an inhibitor of a prosurvival bcl2 family protein

Publications (1)

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BR112021024822A2 true BR112021024822A2 (pt) 2022-04-12

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BR112021024822A BR112021024822A2 (pt) 2019-06-12 2020-06-11 Terapia de combinação de terapia citotóxica mediada por células e inibidor de proteína da família bcl2 pró-sobrevivência

Country Status (13)

Country Link
US (1) US20220249637A1 (pt)
EP (1) EP3983006A1 (pt)
JP (1) JP2022537700A (pt)
KR (1) KR20220034782A (pt)
CN (1) CN114269371A (pt)
AU (1) AU2020293230A1 (pt)
BR (1) BR112021024822A2 (pt)
CA (1) CA3142361A1 (pt)
IL (1) IL288498A (pt)
MA (1) MA56206A (pt)
MX (1) MX2021015317A (pt)
SG (1) SG11202113356XA (pt)
WO (1) WO2020252218A1 (pt)

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CN115279375A (zh) 2019-11-05 2022-11-01 艾伯维公司 用于以navitoclax治疗骨髓纤维化和mpn相关病症的给药方案
CN116635062A (zh) * 2020-11-13 2023-08-22 诺华股份有限公司 使用表达嵌合抗原受体（car）的细胞的组合疗法
WO2022133030A1 (en) * 2020-12-16 2022-06-23 Juno Therapeutics, Inc. Combination therapy of a cell therapy and a bcl2 inhibitor
EP4291236A1 (en) * 2021-03-05 2023-12-20 Duke University Compositions for and methods of preventing metastases
CA3228635A1 (en) * 2021-08-11 2023-02-16 The Trustees Of The University Of Pennsylvania Modulation of bcl-2 to enhance chimeric antigen receptor cancer immunotherapy efficacy
CN114414541A (zh) * 2021-12-17 2022-04-29 上海药明生物医药有限公司 一种应用3d细胞成像分析系统检测t细胞杀伤效力的方法

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