BR112021024398A2 - Processo alternativo para a preparação de ácido 4-fenil-5-alcoxicarbonil-2-tiazol-2-il-1,4-di-hidropirimidin-6-il]metil]-3-oxo-5,6,8,8a-tetra-hidro-1h-imidazo[1,5-a]pirazin-2-il]-carboxílico - Google Patents

Processo alternativo para a preparação de ácido 4-fenil-5-alcoxicarbonil-2-tiazol-2-il-1,4-di-hidropirimidin-6-il]metil]-3-oxo-5,6,8,8a-tetra-hidro-1h-imidazo[1,5-a]pirazin-2-il]-carboxílico

Info

Publication number
BR112021024398A2
BR112021024398A2 BR112021024398A BR112021024398A BR112021024398A2 BR 112021024398 A2 BR112021024398 A2 BR 112021024398A2 BR 112021024398 A BR112021024398 A BR 112021024398A BR 112021024398 A BR112021024398 A BR 112021024398A BR 112021024398 A2 BR112021024398 A2 BR 112021024398A2
Authority
BR
Brazil
Prior art keywords
phenyl
alternative process
dihydropyrimidin
pyrazin
thiazol
Prior art date
Application number
BR112021024398A
Other languages
English (en)
Inventor
Vincent Fishlock Daniel
Fugui Zhang
Georg Wuitschik
Jianshu Liu
Paul Spurr
Zhixiang Xu
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR112021024398A2 publication Critical patent/BR112021024398A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

processo alternativo para a preparação de ácido 4-fenil-5-alcoxicarbonil-2-tiazol-2-il-1,4-di-hidropirimidin-6-il]metil]-3-oxo-5,6,8,8a-tetra-hidro-1h-imidazo[1,5-a]pirazin-2-il]-carboxílico. a presente invenção se refere a um processo alternativo para sintetizar um composto de fórmula (i), r1 é fenila, que é não substituída ou substituída com um, dois ou três substituintes independentemente selecionados a partir de halogênio e c1-6alquila; r2 é c1-6alquila; r3 é -cxh2x-; x é 1, 2, 3, 4, 5, 6 ou 7; ou sal ou diastereômero farmaceuticamente aceitável do mesmo, que é útil para profilaxia e tratamento de uma doença viral em um paciente relacionada à infecção por hepatite b ou uma doença causada por infecção por hepatite b.
BR112021024398A 2019-06-06 2020-06-04 Processo alternativo para a preparação de ácido 4-fenil-5-alcoxicarbonil-2-tiazol-2-il-1,4-di-hidropirimidin-6-il]metil]-3-oxo-5,6,8,8a-tetra-hidro-1h-imidazo[1,5-a]pirazin-2-il]-carboxílico BR112021024398A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2019090358 2019-06-06
PCT/EP2020/065424 WO2020245246A1 (en) 2019-06-06 2020-06-04 Alternative process for the preparation of 4-phenyl-5-alkoxycarbonyl-2-thiazol-2-yl-1,4-dihydropyrimidin-6-yl]methyl]-3-oxo-5,6,8,8a-tetrahydro-1h-imidazo[1,5-a]pyrazin-2-yl]-carboxylic acid

Publications (1)

Publication Number Publication Date
BR112021024398A2 true BR112021024398A2 (pt) 2022-01-18

Family

ID=71069823

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112021024398A BR112021024398A2 (pt) 2019-06-06 2020-06-04 Processo alternativo para a preparação de ácido 4-fenil-5-alcoxicarbonil-2-tiazol-2-il-1,4-di-hidropirimidin-6-il]metil]-3-oxo-5,6,8,8a-tetra-hidro-1h-imidazo[1,5-a]pirazin-2-il]-carboxílico

Country Status (14)

Country Link
US (1) US20220315588A1 (pt)
EP (1) EP3980419A1 (pt)
JP (1) JP2022535112A (pt)
KR (1) KR20220018486A (pt)
CN (1) CN114026095A (pt)
AR (1) AR119098A1 (pt)
AU (1) AU2020288329A1 (pt)
BR (1) BR112021024398A2 (pt)
CA (1) CA3142659A1 (pt)
IL (1) IL288585A (pt)
MX (1) MX2021014850A (pt)
SG (1) SG11202111538PA (pt)
TW (1) TW202112781A (pt)
WO (1) WO2020245246A1 (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020193459A1 (en) 2019-03-25 2020-10-01 F. Hoffmann-La Roche Ag Solid forms of a compound of hbv core protein allosteric modifier

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100348588C (zh) * 2005-12-02 2007-11-14 浙江工业大学 一种嘧啶硫酮的化学合成方法
BR112016020566B1 (pt) * 2014-03-07 2022-11-29 F. Hoffmann-La Roche Ag Novas heteroaril-diidro-pirimidinas fundidas na posição 6 para o tratamento e profilaxia da infecção pelo vírus da hepatite b
WO2017064156A1 (en) * 2015-10-16 2017-04-20 F. Hoffmann-La Roche Ag Novel 6-fused and 2-heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection
AR107633A1 (es) 2016-02-19 2018-05-16 Hoffmann La Roche Procedimiento para la preparación del ácido 4-fenil-5-alcoxicarbonil-2-tiazol-2-il-1,4-dihidropirimidin-6-il-[metil]-3-oxo-5,6,8,8a-tetrahidro-1h-imidazo[1,5a]pirazin-2-il-carboxílico
JP6957518B2 (ja) * 2016-05-20 2021-11-02 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 感染症の治療のための酸素、硫黄および窒素リンカーを有する新規ピラジン化合物
JP2021008404A (ja) * 2017-09-27 2021-01-28 アスタファーマシューティカルズ株式会社 変形性関節症改善剤
JP7202373B2 (ja) * 2017-10-18 2023-01-11 サンシャイン・レイク・ファーマ・カンパニー・リミテッド ジヒドロピリミジン化合物、及び医薬におけるその使用

Also Published As

Publication number Publication date
IL288585A (en) 2022-02-01
EP3980419A1 (en) 2022-04-13
CA3142659A1 (en) 2020-12-10
AU2020288329A1 (en) 2021-11-18
TW202112781A (zh) 2021-04-01
CN114026095A (zh) 2022-02-08
JP2022535112A (ja) 2022-08-04
WO2020245246A1 (en) 2020-12-10
MX2021014850A (es) 2022-01-18
AR119098A1 (es) 2021-11-24
US20220315588A1 (en) 2022-10-06
KR20220018486A (ko) 2022-02-15
SG11202111538PA (en) 2021-11-29

Similar Documents

Publication Publication Date Title
BR112018016932A2 (pt) processo para a preparação de ácido 4 -fenil -5 -alcoxicarbonil -2 -tiazol -2 -il -1,4 -diidropirimidin -6 -il[metil] -3 -oxo -5,6,8,8a -tetrahidro -1h -imidazo[1,5 -a]pirazin -2 -il] -carboxil acid
MA41338B1 (fr) Composés de pyrazine pour le traitement de maladies infectieuses
AR103222A1 (es) Procedimiento para la preparación de análogos de 4-fenil-5-alcoxicarbonil-2-tiazol-2-il-1,4-dihidropirimidina
EA202092169A1 (ru) ПРИМЕНЕНИЕ ЗАМЕЩЕННЫХ АМИНОПРОПИОНАТНЫХ СОЕДИНЕНИЙ В ЛЕЧЕНИИ ИНФЕКЦИИ SARS-CoV-2
EA201391158A1 (ru) Диаминиевые соли фенотиазина и их применение
MA41134A (fr) Composés substitués de 5-amino-6h-thiazolo[4,5-d]pyrimidine-2,7-dione pour le traitement et la prophylaxie des infections virales
MA46038A (fr) Composés de sulfonimidoylpurinone substitués dans la position 7 pour le traitement et la prophylaxie d'infection virale
UY28084A1 (es) Derivados antivirales de nucleosidos
EA200301216A1 (ru) Замещенные хинуклидинами мультициклические гетероарилы для лечения заболевания
EA201391519A1 (ru) 2'-замещенные нуклеозидные производные и способы их применения для лечения вирусных заболеваний
EA202090514A1 (ru) Противовирусное средство против гепатита в
AR084976A1 (es) Compuestos de bifenileno sustituidos y metodos de uso de los mismos para el tratamiento de enfermedades virales
DE602007008616D1 (de) Verfahren zur herstellung von 4'-azidocytidinderivaten
WO2013052263A2 (en) Antifungal compounds
EA201591328A1 (ru) Замещенные гетероциклом тетрациклические соединения и способы их применения для лечения вирусных заболеваний
RU2013116801A (ru) Ингибиторы notum пектинацетилэстеразы и способы их применения
BRPI0518615A2 (pt) derivados de malonamida
BR112022010181A2 (pt) Composto tri-heterocíclico como inibidor de jak e uso do mesmo
BR112018003489A2 (pt) n-[2-(2-amino-6,6-dissubstituído-4,4a,5,6-tetra-hidropirano[3,4-d][1,3]tiazin-8a(8h)-il)-1,3-tiazol-4-il]amidas
ATE523498T1 (de) Hiv-inhibierende 2-(4- cyanophenylamino)pyrimidinderivate
BR112021018578A2 (pt) Compostos de heterociclil(fenil)metanol úteis no tratamento de hiperglicemia
RU2016149761A (ru) Производные нуклеозидов для лечения ракового заболевания
RU2016151973A (ru) Пиридиноны, замещенные фенилом и трет-бутилуксусной кислотой, обладающие анти-вич эффектами
BR112021024398A2 (pt) Processo alternativo para a preparação de ácido 4-fenil-5-alcoxicarbonil-2-tiazol-2-il-1,4-di-hidropirimidin-6-il]metil]-3-oxo-5,6,8,8a-tetra-hidro-1h-imidazo[1,5-a]pirazin-2-il]-carboxílico
JP2007507467A5 (pt)