SG11202111538PA - Alternative process for the preparation of 4-phenyl-5-alkoxycarbonyl-2-thiazol-2-yl-1,4-dihydropyrimidin-6-yl]methyl]-3-oxo-5,6,8,8a-tetrahydro-1h-imidazo[1,5-a]pyrazin-2-yl]-carboxylic acid - Google Patents

Alternative process for the preparation of 4-phenyl-5-alkoxycarbonyl-2-thiazol-2-yl-1,4-dihydropyrimidin-6-yl]methyl]-3-oxo-5,6,8,8a-tetrahydro-1h-imidazo[1,5-a]pyrazin-2-yl]-carboxylic acid

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Publication number
SG11202111538PA
SG11202111538PA SG11202111538PA SG11202111538PA SG11202111538PA SG 11202111538P A SG11202111538P A SG 11202111538PA SG 11202111538P A SG11202111538P A SG 11202111538PA SG 11202111538P A SG11202111538P A SG 11202111538PA SG 11202111538P A SG11202111538P A SG 11202111538PA
Authority
SG
Singapore
Prior art keywords
dihydropyrimidin
pyrazin
thiazol
imidazo
alkoxycarbonyl
Prior art date
Application number
SG11202111538PA
Other languages
English (en)
Inventor
Daniel Vincent Fishlock
Jianshu Liu
Paul Spurr
Georg Wuitschik
Zhixiang Xu
Fugui Zhang
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of SG11202111538PA publication Critical patent/SG11202111538PA/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SG11202111538PA 2019-06-06 2020-06-04 Alternative process for the preparation of 4-phenyl-5-alkoxycarbonyl-2-thiazol-2-yl-1,4-dihydropyrimidin-6-yl]methyl]-3-oxo-5,6,8,8a-tetrahydro-1h-imidazo[1,5-a]pyrazin-2-yl]-carboxylic acid SG11202111538PA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2019090358 2019-06-06
PCT/EP2020/065424 WO2020245246A1 (en) 2019-06-06 2020-06-04 Alternative process for the preparation of 4-phenyl-5-alkoxycarbonyl-2-thiazol-2-yl-1,4-dihydropyrimidin-6-yl]methyl]-3-oxo-5,6,8,8a-tetrahydro-1h-imidazo[1,5-a]pyrazin-2-yl]-carboxylic acid

Publications (1)

Publication Number Publication Date
SG11202111538PA true SG11202111538PA (en) 2021-11-29

Family

ID=71069823

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202111538PA SG11202111538PA (en) 2019-06-06 2020-06-04 Alternative process for the preparation of 4-phenyl-5-alkoxycarbonyl-2-thiazol-2-yl-1,4-dihydropyrimidin-6-yl]methyl]-3-oxo-5,6,8,8a-tetrahydro-1h-imidazo[1,5-a]pyrazin-2-yl]-carboxylic acid

Country Status (14)

Country Link
US (1) US20220315588A1 (pt)
EP (1) EP3980419A1 (pt)
JP (1) JP7532420B2 (pt)
KR (1) KR20220018486A (pt)
CN (1) CN114026095A (pt)
AR (1) AR119098A1 (pt)
AU (1) AU2020288329A1 (pt)
BR (1) BR112021024398A2 (pt)
CA (1) CA3142659A1 (pt)
IL (1) IL288585A (pt)
MX (1) MX2021014850A (pt)
SG (1) SG11202111538PA (pt)
TW (1) TW202112781A (pt)
WO (1) WO2020245246A1 (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113614088A (zh) 2019-03-25 2021-11-05 豪夫迈·罗氏有限公司 Hbv核心蛋白变构修饰剂化合物的固体形式

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100348588C (zh) * 2005-12-02 2007-11-14 浙江工业大学 一种嘧啶硫酮的化学合成方法
CA2935811C (en) 2014-03-07 2018-09-18 F. Hoffmann-La Roche Ag 6-fused heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection
PT3270915T (pt) 2015-03-16 2020-06-17 H Hoffnabb La Roche Ag Tratamento combinado com um agonista do tlr7 e um inibidor da montagem da cápside do vhb
WO2017064156A1 (en) * 2015-10-16 2017-04-20 F. Hoffmann-La Roche Ag Novel 6-fused and 2-heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection
AR107633A1 (es) 2016-02-19 2018-05-16 Hoffmann La Roche Procedimiento para la preparación del ácido 4-fenil-5-alcoxicarbonil-2-tiazol-2-il-1,4-dihidropirimidin-6-il-[metil]-3-oxo-5,6,8,8a-tetrahidro-1h-imidazo[1,5a]pirazin-2-il-carboxílico
EP3458455B1 (en) * 2016-05-20 2021-06-16 F. Hoffmann-La Roche AG Novel pyrazine compounds with oxygen, sulfur and nitrogen linker for the treatment of infectious diseases
JP2021008404A (ja) * 2017-09-27 2021-01-28 アスタファーマシューティカルズ株式会社 変形性関節症改善剤
JP7202373B2 (ja) * 2017-10-18 2023-01-11 サンシャイン・レイク・ファーマ・カンパニー・リミテッド ジヒドロピリミジン化合物、及び医薬におけるその使用
JP2022511819A (ja) 2018-12-20 2022-02-01 ヤンセン ファーマシューティカ エヌ．ベー． ヘテロアリールジヒドロピリミジン誘導体及びｂ型肝炎感染症を治療する方法

Also Published As

Publication number Publication date
AU2020288329A1 (en) 2021-11-18
US20220315588A1 (en) 2022-10-06
CA3142659A1 (en) 2020-12-10
EP3980419A1 (en) 2022-04-13
IL288585A (en) 2022-02-01
TW202112781A (zh) 2021-04-01
MX2021014850A (es) 2022-01-18
KR20220018486A (ko) 2022-02-15
WO2020245246A1 (en) 2020-12-10
JP7532420B2 (ja) 2024-08-13
AR119098A1 (es) 2021-11-24
JP2022535112A (ja) 2022-08-04
BR112021024398A2 (pt) 2022-01-18
CN114026095A (zh) 2022-02-08

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