BR112021021856A2 - Combinação de marcador de microrna para diagnosticar câncer gástrico e kit de diagnóstico - Google Patents
Combinação de marcador de microrna para diagnosticar câncer gástrico e kit de diagnósticoInfo
- Publication number
- BR112021021856A2 BR112021021856A2 BR112021021856A BR112021021856A BR112021021856A2 BR 112021021856 A2 BR112021021856 A2 BR 112021021856A2 BR 112021021856 A BR112021021856 A BR 112021021856A BR 112021021856 A BR112021021856 A BR 112021021856A BR 112021021856 A2 BR112021021856 A2 BR 112021021856A2
- Authority
- BR
- Brazil
- Prior art keywords
- hsa
- mir
- gastric cancer
- diagnostic kit
- marker combination
- Prior art date
Links
- 208000005718 Stomach Neoplasms Diseases 0.000 title abstract 7
- 206010017758 gastric cancer Diseases 0.000 title abstract 6
- 201000011549 stomach cancer Diseases 0.000 title abstract 6
- 239000003550 marker Substances 0.000 title abstract 5
- 108091070501 miRNA Proteins 0.000 title abstract 4
- 238000009007 Diagnostic Kit Methods 0.000 title abstract 3
- 108091068855 Homo sapiens miR-103a-1 stem-loop Proteins 0.000 abstract 1
- 108091068838 Homo sapiens miR-103a-2 stem-loop Proteins 0.000 abstract 1
- 108091069085 Homo sapiens miR-126 stem-loop Proteins 0.000 abstract 1
- 108091069017 Homo sapiens miR-140 stem-loop Proteins 0.000 abstract 1
- 108091068993 Homo sapiens miR-142 stem-loop Proteins 0.000 abstract 1
- 108091067469 Homo sapiens miR-181a-1 stem-loop Proteins 0.000 abstract 1
- 108091067618 Homo sapiens miR-181a-2 stem-loop Proteins 0.000 abstract 1
- 108091067605 Homo sapiens miR-183 stem-loop Proteins 0.000 abstract 1
- 108091070493 Homo sapiens miR-21 stem-loop Proteins 0.000 abstract 1
- 108091065168 Homo sapiens miR-29c stem-loop Proteins 0.000 abstract 1
- 108091065436 Homo sapiens miR-30e stem-loop Proteins 0.000 abstract 1
- 108091066899 Homo sapiens miR-340 stem-loop Proteins 0.000 abstract 1
- 108091032108 Homo sapiens miR-424 stem-loop Proteins 0.000 abstract 1
- 108091070377 Homo sapiens miR-93 stem-loop Proteins 0.000 abstract 1
- 108091008065 MIR21 Proteins 0.000 abstract 1
- 239000002679 microRNA Substances 0.000 abstract 1
- 210000002966 serum Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Hospice & Palliative Care (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910392316.2A CN110029169A (zh) | 2019-04-30 | 2019-04-30 | 一种检测胃癌的miRNA标志物组合及试剂盒 |
| PCT/CN2020/084687 WO2020220994A1 (zh) | 2019-04-30 | 2020-04-14 | 一种检测胃癌的miRNA标志物组合及试剂盒 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112021021856A2 true BR112021021856A2 (pt) | 2022-01-18 |
Family
ID=67241908
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112021021856A BR112021021856A2 (pt) | 2019-04-30 | 2020-04-14 | Combinação de marcador de microrna para diagnosticar câncer gástrico e kit de diagnóstico |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20220186320A1 (https=) |
| EP (1) | EP3967767A4 (https=) |
| JP (2) | JP7676321B2 (https=) |
| KR (1) | KR20220009970A (https=) |
| CN (4) | CN117683886A (https=) |
| AU (1) | AU2020265027A1 (https=) |
| BR (1) | BR112021021856A2 (https=) |
| CL (1) | CL2021002852A1 (https=) |
| CO (1) | CO2021015520A2 (https=) |
| MX (1) | MX2021013424A (https=) |
| PH (1) | PH12021552764A1 (https=) |
| SG (1) | SG11202112095VA (https=) |
| WO (1) | WO2020220994A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117683886A (zh) * | 2019-04-30 | 2024-03-12 | 觅瑞实验室私人有限公司 | 一种检测胃癌的miRNA标志物组合及试剂盒 |
| CN111321224B (zh) * | 2019-12-27 | 2023-09-15 | 陈锦飞 | 一种用于诊断或辅助诊断胃癌的miRNA生物标志物组合及其试剂盒 |
| CN111471764B (zh) * | 2019-12-27 | 2023-09-15 | 陈锦飞 | 一种用于筛查或辅助诊断胃癌的生物标志物组合及其试剂盒和应用 |
| CN111312405A (zh) * | 2020-02-12 | 2020-06-19 | 宁德市闽东医院 | 一种健康体检胃癌筛查评估及管理系统 |
| CN111471683B (zh) * | 2020-04-15 | 2021-09-07 | 湖南省科域生物医药科技有限公司 | miR-93-5p作为诊断和治疗胃癌标志物的应用 |
| CN112226514B (zh) * | 2020-11-23 | 2021-08-03 | 苏州京脉生物科技有限公司 | 用于早期胃癌检测的标志物组合、试剂盒及其应用 |
| CN113151413A (zh) * | 2021-04-28 | 2021-07-23 | 杭州觅因生物科技有限公司 | 一种具有校准功能的microRNA检测试剂盒 |
| CN113186285B (zh) * | 2021-05-10 | 2022-05-24 | 深圳市展行生物有限公司 | 一种辅助诊断胃癌的方法及其使用的miRNA组合 |
| CN114875151B (zh) * | 2022-06-15 | 2023-05-16 | 北京肿瘤医院(北京大学肿瘤医院) | 血浆外泌体生物标志物在胃癌新辅助化疗敏感人群筛查或疗效预测中的应用 |
| CN116179691A (zh) * | 2022-09-07 | 2023-05-30 | 苏州大学附属第一医院 | 一种胃癌组合标志物及标志物模型的建立方法 |
| CN116926192B (zh) * | 2023-05-17 | 2025-01-24 | 山东大学 | 一种基于链置换反应的肿瘤标志物miRNA与mRNA荧光共检测方法及其在胃癌诊断中的应用 |
| CN119351558A (zh) * | 2024-12-10 | 2025-01-24 | 西藏自治区人民政府驻成都办事处医院 | 一种检测胃癌的标志物、检测试剂盒及药物 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2716906A1 (en) * | 2008-02-28 | 2009-09-03 | The Ohio State University Research Foundation | Microrna-based methods and compositions for the diagnosis, prognosis and treatment of gastric cancer |
| CN102892897B (zh) * | 2009-12-24 | 2016-08-03 | 复旦大学 | 用于肺癌的微rna表达谱分析的组合物和方法 |
| US9850527B2 (en) | 2010-06-14 | 2017-12-26 | National University Of Singapore | Modified stem-loop oligonucleotide mediated reverse transcription and base-spacing constrained quantitative PCR |
| KR101381894B1 (ko) * | 2012-02-28 | 2014-04-14 | 부산대학교 산학협력단 | 위암의 림프절 전이 진단 마커로서의 혈청 ｍｉＲＮＡ |
| CN103937888B (zh) * | 2014-04-14 | 2016-08-17 | 上海交通大学 | 鉴别胃癌的血浆microRNA标志物的筛选与应用 |
| EP4718079A2 (en) * | 2014-06-16 | 2026-04-01 | Toray Industries, Inc. | Stomach cancer biomarker and detection method |
| EP3177739B1 (en) * | 2014-08-07 | 2019-10-23 | Agency For Science, Technology And Research | Microrna biomarker for the diagnosis of gastric cancer |
| WO2016034715A2 (fr) * | 2014-09-05 | 2016-03-10 | Prestizia | Methode de prediction de l'evolution clinique du cancer colorectal |
| WO2016144265A1 (en) * | 2015-03-09 | 2016-09-15 | Agency For Science, Technology And Research | Method of determining the risk of developing breast cancer by detecting the expression levels of micrornas (mirnas) |
| CN105219867B (zh) * | 2015-11-02 | 2016-08-17 | 北京博奥医学检验所有限公司 | 用于胃癌诊断的miRNA生物标志物及检测试剂盒 |
| CN106086178B (zh) * | 2016-06-16 | 2020-03-31 | 朱伟 | 一种与胃癌辅助诊断相关的血清miRNA标志物及其应用 |
| CN106755377B (zh) * | 2016-12-12 | 2021-05-25 | 浙江省中医院 | 一种胃癌血清学检测鉴定试剂盒及方法 |
| CN107746880B (zh) * | 2017-11-01 | 2018-12-14 | 健生生物技术有限公司 | 一种基于RT-qPCR法检测胃癌的试剂盒及其制备方法和应用 |
| CN109609630B (zh) * | 2018-12-03 | 2023-01-13 | 哈尔滨医科大学 | 用于早期胃癌诊断的分子标志物及其应用 |
| CN117683886A (zh) * | 2019-04-30 | 2024-03-12 | 觅瑞实验室私人有限公司 | 一种检测胃癌的miRNA标志物组合及试剂盒 |
-
2019
- 2019-04-30 CN CN202311539926.3A patent/CN117683886A/zh active Pending
- 2019-04-30 CN CN202211194423.2A patent/CN115537466A/zh active Pending
- 2019-04-30 CN CN201910392316.2A patent/CN110029169A/zh active Pending
- 2019-04-30 CN CN202311539925.9A patent/CN117683885A/zh active Pending
-
2020
- 2020-04-14 PH PH1/2021/552764A patent/PH12021552764A1/en unknown
- 2020-04-14 US US17/594,805 patent/US20220186320A1/en active Pending
- 2020-04-14 AU AU2020265027A patent/AU2020265027A1/en active Pending
- 2020-04-14 JP JP2021564879A patent/JP7676321B2/ja active Active
- 2020-04-14 MX MX2021013424A patent/MX2021013424A/es unknown
- 2020-04-14 KR KR1020217039294A patent/KR20220009970A/ko not_active Ceased
- 2020-04-14 EP EP20798831.2A patent/EP3967767A4/en active Pending
- 2020-04-14 BR BR112021021856A patent/BR112021021856A2/pt unknown
- 2020-04-14 WO PCT/CN2020/084687 patent/WO2020220994A1/zh not_active Ceased
- 2020-04-14 SG SG11202112095VA patent/SG11202112095VA/en unknown
-
2021
- 2021-10-29 CL CL2021002852A patent/CL2021002852A1/es unknown
- 2021-11-18 CO CONC2021/0015520A patent/CO2021015520A2/es unknown
-
2025
- 2025-04-30 JP JP2025075678A patent/JP2025114665A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2025114665A (ja) | 2025-08-05 |
| WO2020220994A1 (zh) | 2020-11-05 |
| CL2021002852A1 (es) | 2022-06-10 |
| CN117683886A (zh) | 2024-03-12 |
| EP3967767A4 (en) | 2023-06-14 |
| JP7676321B2 (ja) | 2025-05-14 |
| MX2021013424A (es) | 2022-02-11 |
| CN117683885A (zh) | 2024-03-12 |
| EP3967767A1 (en) | 2022-03-16 |
| AU2020265027A1 (en) | 2021-12-09 |
| CN115537466A (zh) | 2022-12-30 |
| CN110029169A (zh) | 2019-07-19 |
| KR20220009970A (ko) | 2022-01-25 |
| PH12021552764A1 (en) | 2022-07-11 |
| US20220186320A1 (en) | 2022-06-16 |
| CO2021015520A2 (es) | 2022-01-17 |
| JP2022533033A (ja) | 2022-07-21 |
| SG11202112095VA (en) | 2021-12-30 |
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