BR112018005494A2 - composto, composição farmacêutica, e, método de tratamento de um paciente com uma doença. - Google Patents
composto, composição farmacêutica, e, método de tratamento de um paciente com uma doença.Info
- Publication number
- BR112018005494A2 BR112018005494A2 BR112018005494A BR112018005494A BR112018005494A2 BR 112018005494 A2 BR112018005494 A2 BR 112018005494A2 BR 112018005494 A BR112018005494 A BR 112018005494A BR 112018005494 A BR112018005494 A BR 112018005494A BR 112018005494 A2 BR112018005494 A2 BR 112018005494A2
- Authority
- BR
- Brazil
- Prior art keywords
- disease
- patient
- treating
- compound
- pharmaceutical composition
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 229960000575 trastuzumab Drugs 0.000 abstract 2
- 241000251468 Actinopterygii Species 0.000 abstract 1
- 206010006187 Breast cancer Diseases 0.000 abstract 1
- 208000026310 Breast neoplasm Diseases 0.000 abstract 1
- 101100314454 Caenorhabditis elegans tra-1 gene Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 229940125644 antibody drug Drugs 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- VQNATVDKACXKTF-XELLLNAOSA-N duocarmycin Chemical compound COC1=C(OC)C(OC)=C2NC(C(=O)N3C4=CC(=O)C5=C([C@@]64C[C@@H]6C3)C=C(N5)C(=O)OC)=CC2=C1 VQNATVDKACXKTF-XELLLNAOSA-N 0.000 abstract 1
- 229960005501 duocarmycin Drugs 0.000 abstract 1
- 229930184221 duocarmycin Natural products 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
- A61K47/6855—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from breast cancer cell
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
Abstract
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP15186258 | 2015-09-22 | ||
EP16158710 | 2016-03-04 | ||
EP16169699 | 2016-05-13 | ||
PCT/EP2016/072464 WO2017050846A1 (en) | 2015-09-22 | 2016-09-21 | Syd985 treatment of t-dm1 refractory cancer patients |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112018005494A2 true BR112018005494A2 (pt) | 2018-10-09 |
Family
ID=57068063
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112018005494A BR112018005494A2 (pt) | 2015-09-22 | 2016-09-21 | composto, composição farmacêutica, e, método de tratamento de um paciente com uma doença. |
Country Status (21)
Country | Link |
---|---|
US (1) | US10821191B2 (pt) |
EP (1) | EP3352857B1 (pt) |
JP (1) | JP6591665B2 (pt) |
KR (1) | KR20180052761A (pt) |
CN (1) | CN108025190A (pt) |
AU (1) | AU2016328461B2 (pt) |
BR (1) | BR112018005494A2 (pt) |
CA (1) | CA2996600A1 (pt) |
CL (1) | CL2018000726A1 (pt) |
CY (1) | CY1123818T1 (pt) |
DK (1) | DK3352857T3 (pt) |
ES (1) | ES2854298T3 (pt) |
HR (1) | HRP20210418T1 (pt) |
HU (1) | HUE053614T2 (pt) |
LT (1) | LT3352857T (pt) |
MX (1) | MX2018003459A (pt) |
MY (1) | MY194488A (pt) |
PL (1) | PL3352857T3 (pt) |
RU (1) | RU2728101C2 (pt) |
WO (1) | WO2017050846A1 (pt) |
ZA (1) | ZA201801022B (pt) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK3876997T3 (da) * | 2018-11-09 | 2022-09-26 | Byondis Bv | Filtrerbare duocarmycin-holdige antistof-lægemiddelkonjugatsammensætninger og tilhørende fremgangsmåder |
IL293626A (en) * | 2019-12-20 | 2022-08-01 | Pfizer | Treatment with antibody-drug conjugates specific for the her2 site |
JP7455316B2 (ja) * | 2021-10-20 | 2024-03-26 | 国立研究開発法人産業技術総合研究所 | 抗ガン剤、抗ガン剤のプロドラッグ、体外でガン細胞を死滅させる方法、ガンの治療方法、及びガンの治療装置 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2010003718A (es) * | 2007-10-19 | 2010-04-21 | Genentech Inc | Anticuerpos anti-tenb2 producidos por ingenieria de cisteina y conjugados de farmaco y anticuerpo. |
PL2560645T3 (pl) * | 2010-04-21 | 2017-01-31 | Syntarga B.V. | Koniugaty analogów CC-1065 i łączników dwufunkcyjnych |
SG10201911860VA (en) | 2014-01-10 | 2020-02-27 | Synthon Biopharmaceuticals Bv | Duocarmycin adcs showing improved in vivo antitumor activity |
-
2016
- 2016-09-21 KR KR1020187010953A patent/KR20180052761A/ko unknown
- 2016-09-21 CN CN201680054664.3A patent/CN108025190A/zh active Pending
- 2016-09-21 ES ES16775553T patent/ES2854298T3/es active Active
- 2016-09-21 JP JP2018515142A patent/JP6591665B2/ja active Active
- 2016-09-21 LT LTEP16775553.7T patent/LT3352857T/lt unknown
- 2016-09-21 EP EP16775553.7A patent/EP3352857B1/en active Active
- 2016-09-21 MY MYPI2018000414A patent/MY194488A/en unknown
- 2016-09-21 CA CA2996600A patent/CA2996600A1/en active Pending
- 2016-09-21 DK DK16775553.7T patent/DK3352857T3/da active
- 2016-09-21 BR BR112018005494A patent/BR112018005494A2/pt not_active Application Discontinuation
- 2016-09-21 AU AU2016328461A patent/AU2016328461B2/en active Active
- 2016-09-21 WO PCT/EP2016/072464 patent/WO2017050846A1/en active Application Filing
- 2016-09-21 PL PL16775553T patent/PL3352857T3/pl unknown
- 2016-09-21 RU RU2018114457A patent/RU2728101C2/ru active
- 2016-09-21 HU HUE16775553A patent/HUE053614T2/hu unknown
- 2016-09-21 MX MX2018003459A patent/MX2018003459A/es unknown
- 2016-09-21 US US15/762,171 patent/US10821191B2/en active Active
-
2018
- 2018-02-14 ZA ZA2018/01022A patent/ZA201801022B/en unknown
- 2018-03-20 CL CL2018000726A patent/CL2018000726A1/es unknown
-
2021
- 2021-02-16 CY CY20211100128T patent/CY1123818T1/el unknown
- 2021-03-12 HR HRP20210418TT patent/HRP20210418T1/hr unknown
Also Published As
Publication number | Publication date |
---|---|
RU2018114457A3 (pt) | 2020-01-31 |
RU2018114457A (ru) | 2019-10-24 |
CN108025190A (zh) | 2018-05-11 |
ZA201801022B (en) | 2021-05-26 |
PL3352857T3 (pl) | 2021-08-02 |
DK3352857T3 (da) | 2021-03-01 |
KR20180052761A (ko) | 2018-05-18 |
WO2017050846A1 (en) | 2017-03-30 |
US20180280533A1 (en) | 2018-10-04 |
MX2018003459A (es) | 2018-06-06 |
CY1123818T1 (el) | 2022-05-27 |
EP3352857A1 (en) | 2018-08-01 |
LT3352857T (lt) | 2021-02-25 |
CA2996600A1 (en) | 2017-03-30 |
AU2016328461B2 (en) | 2021-04-08 |
US10821191B2 (en) | 2020-11-03 |
EP3352857B1 (en) | 2021-01-13 |
AU2016328461A1 (en) | 2018-02-22 |
JP2018527402A (ja) | 2018-09-20 |
JP6591665B2 (ja) | 2019-10-16 |
CL2018000726A1 (es) | 2018-06-01 |
HRP20210418T1 (hr) | 2021-04-30 |
RU2728101C2 (ru) | 2020-07-28 |
MY194488A (en) | 2022-11-30 |
ES2854298T3 (es) | 2021-09-21 |
HUE053614T2 (hu) | 2021-07-28 |
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Legal Events
Date | Code | Title | Description |
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B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
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B25F | Entry of change of name and/or headquarter and transfer of application, patent and certif. of addition of invention: change of name on requirement |
Owner name: SYNTHON BIOPHARMACEUTICALS B.V (NL) Free format text: A FIM DE ATENDER A ALTERACAO DE NOME REQUERIDA ATRAVES DA PETICAO NO 870200073263, DE 12/06/2020, E NECESSARIO APRESENTAR PROCURACAO COM O NOME ATUAL DA EMPRESA, ALEM DA GUIA DE CUMPRIMENTO DE EXIGENCIA. |
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B25D | Requested change of name of applicant approved |
Owner name: BYONDIS B.V. (NL) |
|
B07G | Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette] |
Free format text: NOTIFICACAO DE DEVOLUCAO DO PEDIDO EM FUNCAO DA REVOGACAO DO ART. 229-C DA LEI NO 9.279, DE 1996, POR FORCA DA LEI NO 14.195, DE 2021 |
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B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B09B | Patent application refused [chapter 9.2 patent gazette] |