BR112021020947A2 - Anticorpos anti-pd-l1 modificados e métodos e usos para o tratamento de uma doença neurodegenerativa - Google Patents

Anticorpos anti-pd-l1 modificados e métodos e usos para o tratamento de uma doença neurodegenerativa

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Publication number
BR112021020947A2
BR112021020947A2 BR112021020947A BR112021020947A BR112021020947A2 BR 112021020947 A2 BR112021020947 A2 BR 112021020947A2 BR 112021020947 A BR112021020947 A BR 112021020947A BR 112021020947 A BR112021020947 A BR 112021020947A BR 112021020947 A2 BR112021020947 A2 BR 112021020947A2
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BR
Brazil
Prior art keywords
antibodies
modified anti
methods
treatment
neurodegenerative disease
Prior art date
Application number
BR112021020947A
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English (en)
Inventor
Allan Jensen
Olsen Krogh Berit
Carol David
Ester Yoles
Jan Egebjerg
Kuti Baruch
Michal Eisenbach-Schwartz
Original Assignee
Immunobrain Checkpoint Inc
Yeda Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Immunobrain Checkpoint Inc, Yeda Res & Dev filed Critical Immunobrain Checkpoint Inc
Publication of BR112021020947A2 publication Critical patent/BR112021020947A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

anticorpos anti-pd-l1 modificados e métodos e usos para otratamento de uma doença neurodegenerativa. o presente relatório descritivo descreve anticorpos anti-pd-l1 modificados que suprimem a função efetora relacionada a fc e aumentam a taxa de depuração, mantendo a eficácia terapêutica para a modificação de doenças neurodegenerativas. o presente relatório descritivo também descreve sequências de ácido nucleico e construções de expressão que codificam tais anticorpos anti-pd-l1 modificados, bem como métodos de produção de tais anticorpos anti-pd-l1 modificados. além disso, o presente relatório descritivo descreve métodos de tratamento e usos que empregam um regime de administração dos anticorpos anti-pd-l1 descritos que garante que os anticorpos estejam presentes por apenas um período de tempo específico e, em seguida, sejam suficientemente eliminados do corpo para garantir que a eficácia do tratamento seja mantida.
BR112021020947A 2019-04-19 2020-04-19 Anticorpos anti-pd-l1 modificados e métodos e usos para o tratamento de uma doença neurodegenerativa BR112021020947A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962836247P 2019-04-19 2019-04-19
EP19170438.6A EP3725370A1 (en) 2019-04-19 2019-04-19 Modified anti-pd-l1 antibodies and methods and uses for treating a neurodegenerative disease
PCT/US2020/028900 WO2020215049A1 (en) 2019-04-19 2020-04-19 Modified anti-pd-l1 antibodies and methods and uses for treating a neurodegenerative disease

Publications (1)

Publication Number Publication Date
BR112021020947A2 true BR112021020947A2 (pt) 2022-04-05

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BR112021020947A BR112021020947A2 (pt) 2019-04-19 2020-04-19 Anticorpos anti-pd-l1 modificados e métodos e usos para o tratamento de uma doença neurodegenerativa

Country Status (14)

Country Link
US (3) US10995141B2 (pt)
EP (2) EP3725370A1 (pt)
JP (1) JP2022529789A (pt)
KR (1) KR20220002972A (pt)
CN (1) CN114007645A (pt)
AU (1) AU2020257283A1 (pt)
BR (1) BR112021020947A2 (pt)
CA (1) CA3137143A1 (pt)
CL (1) CL2021002735A1 (pt)
IL (1) IL287008A (pt)
MX (1) MX2021012783A (pt)
SG (1) SG11202110990RA (pt)
WO (1) WO2020215049A1 (pt)
ZA (1) ZA202109173B (pt)

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