SG11202110990RA - Modified anti-pd-l1 antibodies and methods and uses for treating a neurodegenerative disease - Google Patents

Modified anti-pd-l1 antibodies and methods and uses for treating a neurodegenerative disease

Info

Publication number
SG11202110990RA
SG11202110990RA SG11202110990RA SG11202110990RA SG11202110990RA SG 11202110990R A SG11202110990R A SG 11202110990RA SG 11202110990R A SG11202110990R A SG 11202110990RA SG 11202110990R A SG11202110990R A SG 11202110990RA SG 11202110990R A SG11202110990R A SG 11202110990RA
Authority
SG
Singapore
Prior art keywords
antibodies
treating
methods
neurodegenerative disease
modified anti
Prior art date
Application number
SG11202110990RA
Inventor
Ester Yoles
Berit Olsen Krogh
Allan Jensen
Jan Egebjerg
Carol David
Kuti Baruch
Michal Eisenbach-Schwartz
Original Assignee
Immunobrain Checkpoint Inc
Yeda Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunobrain Checkpoint Inc, Yeda Res & Dev filed Critical Immunobrain Checkpoint Inc
Publication of SG11202110990RA publication Critical patent/SG11202110990RA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
SG11202110990RA 2019-04-19 2020-04-19 Modified anti-pd-l1 antibodies and methods and uses for treating a neurodegenerative disease SG11202110990RA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962836247P 2019-04-19 2019-04-19
EP19170438.6A EP3725370A1 (en) 2019-04-19 2019-04-19 Modified anti-pd-l1 antibodies and methods and uses for treating a neurodegenerative disease
PCT/US2020/028900 WO2020215049A1 (en) 2019-04-19 2020-04-19 Modified anti-pd-l1 antibodies and methods and uses for treating a neurodegenerative disease

Publications (1)

Publication Number Publication Date
SG11202110990RA true SG11202110990RA (en) 2021-10-28

Family

ID=66240002

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202110990RA SG11202110990RA (en) 2019-04-19 2020-04-19 Modified anti-pd-l1 antibodies and methods and uses for treating a neurodegenerative disease

Country Status (14)

Country Link
US (3) US10995141B2 (en)
EP (2) EP3725370A1 (en)
JP (1) JP2022529789A (en)
KR (1) KR20220002972A (en)
CN (1) CN114007645A (en)
AU (1) AU2020257283A1 (en)
BR (1) BR112021020947A2 (en)
CA (1) CA3137143A1 (en)
CL (1) CL2021002735A1 (en)
IL (1) IL287008A (en)
MX (1) MX2021012783A (en)
SG (1) SG11202110990RA (en)
WO (1) WO2020215049A1 (en)
ZA (1) ZA202109173B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114081946A (en) * 2014-03-12 2022-02-25 耶达研究与开发有限公司 Treatment of CNS diseases and injuries by reducing the level or activity of systemic regulatory T cells
TW202246320A (en) * 2021-02-14 2022-12-01 愛爾蘭商普羅帝納生物科學公司 Methods of using antibodies recognizing tau

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Publication number Publication date
WO2020215049A1 (en) 2020-10-22
CL2021002735A1 (en) 2022-05-20
JP2022529789A (en) 2022-06-24
ZA202109173B (en) 2023-04-26
CN114007645A (en) 2022-02-01
BR112021020947A2 (en) 2022-04-05
US10995141B2 (en) 2021-05-04
US20240052038A1 (en) 2024-02-15
AU2020257283A1 (en) 2021-12-16
US20210221893A1 (en) 2021-07-22
US20200332011A1 (en) 2020-10-22
MX2021012783A (en) 2022-02-10
CA3137143A1 (en) 2020-10-22
EP3955961A1 (en) 2022-02-23
EP3725370A1 (en) 2020-10-21
KR20220002972A (en) 2022-01-07
US11732046B2 (en) 2023-08-22
EP3955961A4 (en) 2023-06-14
IL287008A (en) 2021-12-01

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