BR112021002130A2 - formulação líquida, artigo de fabricação ou kit e método para reduzir a oxidação de um polipeptídeo - Google Patents

formulação líquida, artigo de fabricação ou kit e método para reduzir a oxidação de um polipeptídeo Download PDF

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Publication number
BR112021002130A2
BR112021002130A2 BR112021002130-2A BR112021002130A BR112021002130A2 BR 112021002130 A2 BR112021002130 A2 BR 112021002130A2 BR 112021002130 A BR112021002130 A BR 112021002130A BR 112021002130 A2 BR112021002130 A2 BR 112021002130A2
Authority
BR
Brazil
Prior art keywords
antibody
formulation
methionine
oxidation
nat
Prior art date
Application number
BR112021002130-2A
Other languages
English (en)
Portuguese (pt)
Inventor
Cleo Salisbury
Vikas Sharma
Sreedhara Alavattam
Original Assignee
Genentech, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech, Inc. filed Critical Genentech, Inc.
Publication of BR112021002130A2 publication Critical patent/BR112021002130A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
BR112021002130-2A 2018-08-08 2019-08-07 formulação líquida, artigo de fabricação ou kit e método para reduzir a oxidação de um polipeptídeo BR112021002130A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862716239P 2018-08-08 2018-08-08
US62/716,239 2018-08-08
PCT/US2019/045420 WO2020033485A1 (en) 2018-08-08 2019-08-07 Use of tryptophan derivatives and l-methionine for protein formulation

Publications (1)

Publication Number Publication Date
BR112021002130A2 true BR112021002130A2 (pt) 2021-05-04

Family

ID=67777405

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112021002130-2A BR112021002130A2 (pt) 2018-08-08 2019-08-07 formulação líquida, artigo de fabricação ou kit e método para reduzir a oxidação de um polipeptídeo

Country Status (14)

Country Link
US (1) US20210155715A1 (https=)
EP (1) EP3833389A1 (https=)
JP (1) JP7542521B2 (https=)
KR (1) KR102898177B1 (https=)
CN (1) CN112770775A (https=)
AR (1) AR115925A1 (https=)
AU (1) AU2019319822B2 (https=)
BR (1) BR112021002130A2 (https=)
CA (1) CA3106537A1 (https=)
IL (1) IL280525B2 (https=)
MX (1) MX2021001453A (https=)
SG (1) SG11202100601TA (https=)
TW (1) TW202019478A (https=)
WO (1) WO2020033485A1 (https=)

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Also Published As

Publication number Publication date
KR102898177B1 (ko) 2025-12-10
JP2021533149A (ja) 2021-12-02
IL280525B1 (en) 2024-07-01
WO2020033485A1 (en) 2020-02-13
TW202019478A (zh) 2020-06-01
IL280525B2 (en) 2024-11-01
SG11202100601TA (en) 2021-02-25
AU2019319822B2 (en) 2026-04-16
MX2021001453A (es) 2021-04-12
JP7542521B2 (ja) 2024-08-30
AU2019319822A1 (en) 2021-03-18
IL280525A (en) 2021-03-01
US20210155715A1 (en) 2021-05-27
CA3106537A1 (en) 2020-02-13
CN112770775A (zh) 2021-05-07
EP3833389A1 (en) 2021-06-16
AR115925A1 (es) 2021-03-10
KR20210042936A (ko) 2021-04-20

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B06W Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette]