BR112020000989A2 - métodos e composições para tratamento de dor com o uso de capsaicina - Google Patents
métodos e composições para tratamento de dor com o uso de capsaicina Download PDFInfo
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- BR112020000989A2 BR112020000989A2 BR112020000989-0A BR112020000989A BR112020000989A2 BR 112020000989 A2 BR112020000989 A2 BR 112020000989A2 BR 112020000989 A BR112020000989 A BR 112020000989A BR 112020000989 A2 BR112020000989 A2 BR 112020000989A2
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- Prior art keywords
- joint
- cooling article
- knee
- external surface
- skin
- Prior art date
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Classifications
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- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
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- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/10—Cooling bags, e.g. ice-bags
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F2007/0001—Body part
- A61F2007/0039—Leg or parts thereof
- A61F2007/0042—Knee
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
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- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Organic Chemistry (AREA)
- Rheumatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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- Immunology (AREA)
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- Thermal Sciences (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Thermotherapy And Cooling Therapy Devices (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Medicinal Preparation (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762535003P | 2017-07-20 | 2017-07-20 | |
| US62/535,003 | 2017-07-20 | ||
| PCT/US2018/043094 WO2019018769A1 (en) | 2017-07-20 | 2018-07-20 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF PAIN USING CAPSAICINE |
Publications (1)
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|---|---|
| BR112020000989A2 true BR112020000989A2 (pt) | 2020-07-14 |
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| BR112020000989-0A BR112020000989A2 (pt) | 2017-07-20 | 2018-07-20 | métodos e composições para tratamento de dor com o uso de capsaicina |
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| Country | Link |
|---|---|
| US (4) | US20200206166A1 (https=) |
| EP (1) | EP3654961B1 (https=) |
| JP (2) | JP7282736B2 (https=) |
| CN (1) | CN111201015A (https=) |
| AU (1) | AU2018302342B2 (https=) |
| BR (1) | BR112020000989A2 (https=) |
| CA (1) | CA3069540A1 (https=) |
| ES (1) | ES3018268T3 (https=) |
| IL (1) | IL272036B2 (https=) |
| MX (1) | MX2020000488A (https=) |
| WO (1) | WO2019018769A1 (https=) |
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| WO2019018769A1 (en) * | 2017-07-20 | 2019-01-24 | Centrexion Therapeutics Corporation | METHODS AND COMPOSITIONS FOR THE TREATMENT OF PAIN USING CAPSAICINE |
| EP3840739B1 (en) * | 2018-08-24 | 2025-11-12 | Centrexion Therapeutics Corporation | Capsaicin sequential dosing method for treatment of knee joint pain |
| CN114028540B (zh) * | 2021-11-26 | 2023-10-17 | 海南鑫开源医药科技有限公司 | 一种具有镇痛作用的组合物、微针贴片及其制备方法以及应用 |
| CN115006379B (zh) * | 2021-12-28 | 2023-12-15 | 南京清普生物科技有限公司 | 一种trpv1激动剂原位膜剂组合物，及其制备方法和用途 |
| EP4593867A2 (en) * | 2022-09-30 | 2025-08-06 | Extend Biosciences, Inc. | Long-acting parathyroid hormone |
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| US4599342A (en) | 1984-01-16 | 1986-07-08 | The Procter & Gamble Company | Pharmaceutical products providing enhanced analgesia |
| US5099030A (en) | 1987-03-09 | 1992-03-24 | The Procter & Gamble Company | Novel compounds, pharmaceutical compositions, and methods for treating inflammation and pain |
| US5021450A (en) | 1989-05-30 | 1991-06-04 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | New class of compounds having a variable spectrum of activities for capsaicin-like responses, compositions and uses thereof |
| US5431914A (en) | 1992-04-17 | 1995-07-11 | Adekunle; Michael | Method of treating an internal condition by external application of capsaicin without the need for systemic absorption |
| US5985860A (en) | 1992-06-03 | 1999-11-16 | Toppo; Frank | System for transdermal delivery of pain relieving substances |
| US5318960A (en) | 1992-06-03 | 1994-06-07 | Frank Toppo | System for transdermal delivery of pain relieving substances |
| EP0646372B1 (de) | 1993-09-30 | 1999-03-31 | Medichemie Ag | Capsaicin enthaltendes Arzneimittel zur Behandlung chronischer Rhinopathie |
| US5762963A (en) | 1995-06-07 | 1998-06-09 | Emory University | Method and compositions for controlling oral and pharyngeal pain using capsaicinoids |
| US6248788B1 (en) | 1996-11-06 | 2001-06-19 | The Regents Of The University Of California | Therapeutic method with capsaicin and capasicin analogs |
| WO1998020867A1 (en) | 1996-11-15 | 1998-05-22 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Pharmaceutical compositions containing vanilloid agonists in combination with vanilloid antagonists |
| US6060060A (en) | 1997-01-31 | 2000-05-09 | Bmb Patent Holding Corporation | Analgesic compositions from sweet peppers and methods of use thereof |
| ATE219674T1 (de) | 1997-03-13 | 2002-07-15 | James N Campbell | Zusammensetzung enthaltend capsaicin oder seine analogen und lokalanästhetika |
| EP0984781A1 (en) | 1997-05-27 | 2000-03-15 | Algos Pharmaceutical Corporation | Analgesic drug composition containing a capsaicinoid and potentiator therefor |
| CA2442049C (en) | 2001-03-22 | 2010-06-01 | Michael J. Iadarola | Selective ablation of pain-sensing neurons by administration of a vanilloid receptor agonist |
| US20040146590A1 (en) | 2001-03-22 | 2004-07-29 | Iadarola Michael J | Molecular neurochirurgie for pain control administering locally capsaicin or resinferatoxin |
| US20030104085A1 (en) | 2001-12-05 | 2003-06-05 | Yeomans David C. | Methods and compositions for treating back pain |
| JP2005538983A (ja) | 2002-07-19 | 2005-12-22 | メステックス アクチエンゲゼルシャフト | 関節痛の治療のための薬剤を製造するための神経毒性物質の使用および同薬剤を適用する方法 |
| PT1605956E (pt) | 2002-12-18 | 2016-03-09 | Centrexion Therapeutics Corp | Administração de capsaicinóides para o tratamento da osteoartrite |
| US20040156931A1 (en) | 2002-12-18 | 2004-08-12 | Algorx | Administration of capsaicinoids |
| US7943166B2 (en) | 2003-04-10 | 2011-05-17 | Neurogesx, Inc. | Methods and compositions for administration of TRPV1 agonists |
| RU2373953C2 (ru) | 2003-12-19 | 2009-11-27 | Ново Нордиск Хелс Кеа Аг | Стабилизированная композиция, содержащая полипептид фактора vii |
| US20070020299A1 (en) | 2003-12-31 | 2007-01-25 | Pipkin James D | Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid |
| EA200701131A1 (ru) * | 2004-11-24 | 2007-12-28 | Алгоркс Фармасьютикалз, Инк. | Гелеобразная препаративная форма капсаициноида и способы её применения |
| DE502004011941D1 (de) | 2004-12-22 | 2011-01-05 | Mestex Ag | Mischung eines vanilloidrezeptoragonisten mit einer nervenregenerationshemmenden substanz, ihre verwendung für die herstellung eines schmerzmittels und verfahren zur applikation dieses mittels |
| ES2533256T3 (es) | 2004-12-28 | 2015-04-08 | Mestex Ag | Uso de resiniferatoxina (RTX) para la fabricación de un medicamento para el tratamiento del dolor |
| EP1830835B1 (de) | 2004-12-28 | 2012-03-14 | Mestex AG | Verwendung eines vanilloidrezeptoragonisten zusammen mit einem glycosaminoglycan oder proteoglycan f]r die herstellung eines mittels zur behandlung von gelenkschmerzen und verfahren zur applikation dieses mittels |
| EP1865933B1 (en) * | 2005-03-30 | 2015-11-04 | Vanderbilt Royalty Sub L.P. | Low-concentration capsaicin patch and methods for treating neuropathic pain |
| US20080160487A1 (en) | 2006-12-29 | 2008-07-03 | Fairfield Language Technologies | Modularized computer-aided language learning method and system |
| US8158682B2 (en) | 2008-09-12 | 2012-04-17 | Vallinex, Inc. | Instillation administration of capsaicinoids for the treatment of pain |
| CN101507818B (zh) | 2008-12-15 | 2010-11-10 | 中国人民武装警察部队医学院 | 辣椒碱β-环糊精包合物及包合物的脂质体及凝胶 |
| US8637569B2 (en) | 2009-10-22 | 2014-01-28 | Api Genesis, Llc | Methods of increasing solubility of poorly soluble compounds and methods of making and using formulations of such compounds |
| US20130303495A1 (en) | 2009-12-31 | 2013-11-14 | Sov Therapeutics | Emulsion formulations |
| EP2552302B1 (en) * | 2010-03-30 | 2020-07-01 | The Children's Research Institute | Apparatus and method for human algometry |
| EP3388057B1 (en) | 2011-09-09 | 2022-03-09 | Propella Therapeutics, Inc. | A pain relief composition, comprising a trpv1 selective agonist, and manufacture and uses thereof |
| US9566187B2 (en) | 2012-03-13 | 2017-02-14 | Breg, Inc. | Cold therapy systems and methods |
| CA2868416A1 (en) | 2012-04-18 | 2013-10-24 | Mallinckrodt Llc | Immediate release pharmaceutical compositions with abuse deterrent properties |
| ES2699806T3 (es) | 2012-04-18 | 2019-02-12 | SpecGx LLC | Composiciones farmacéuticas, disuasivas del abuso, de liberación inmediata |
| GB201212010D0 (en) | 2012-07-05 | 2012-08-22 | Sigmoid Pharma Ltd | Formulations |
| US11154535B2 (en) | 2012-07-31 | 2021-10-26 | Egis Pharmaceuticals Plc | Transdermal formulation containing COX inhibitors |
| JP2015523401A (ja) | 2012-08-03 | 2015-08-13 | メステックス・アー・ゲー | レシニフェラトキシン溶液 |
| AU2013341380B2 (en) | 2012-11-12 | 2018-04-26 | Propella Therapeutics, Inc. | Aqueous based capsaicinoid formulations, and treatment in combination with a corticosteroid |
| GB201304662D0 (en) | 2013-03-14 | 2013-05-01 | Sigmoid Pharma Ltd | Compositions |
| US9956166B2 (en) | 2013-09-18 | 2018-05-01 | Sorrento Therapeutics, Inc. | Methods for administration and methods for treating cardiovascular diseases with resiniferatoxin |
| GB201317756D0 (en) | 2013-10-08 | 2013-11-20 | Critical Pharmaceuticals Ltd | New process |
| GB201319791D0 (en) | 2013-11-08 | 2013-12-25 | Sigmoid Pharma Ltd | Formulations |
| GB201319792D0 (en) | 2013-11-08 | 2013-12-25 | Sigmoid Pharma Ltd | Formulations |
| US20150133561A1 (en) * | 2013-11-12 | 2015-05-14 | Vizuri Health Sciences Llc | Aqueous based capsaicinoid formulations and methods of manufacture and use |
| JP6487452B2 (ja) | 2014-01-24 | 2019-03-20 | センティス ファーマ プライベート リミテッド | ブリンゾラミドを含む医薬組成物 |
| US20170042834A1 (en) | 2014-04-14 | 2017-02-16 | Flex Pharma, Inc. | Ion channel activators and methods of use |
| MX377377B (es) | 2014-04-15 | 2025-03-10 | Propella Therapeutics Inc | Composiciones tópicas para el alivio del dolor, manufactura y uso. |
| CN105030760B (zh) | 2014-04-24 | 2018-10-02 | 长弘生物科技股份有限公司 | 稳定医药组合物 |
| JP6855248B2 (ja) | 2014-06-25 | 2021-04-07 | ヌカナ ピーエルシー | ゲムシタビン−プロドラッグを含む製剤 |
| WO2015198350A1 (en) | 2014-06-25 | 2015-12-30 | Synergia Bio Sciences Private Limited | A pharmaceutical oil-in-water nano-emulsion |
| KR20170066344A (ko) | 2014-08-19 | 2017-06-14 | 만디쇼라 이스라엘 무자리 | 약제로서의 캡시노이드 및 그의 용도 |
| JP2017534656A (ja) | 2014-11-13 | 2017-11-24 | セントレクシオン セラピューティクス コーポレイション | 肢端舐性肉芽腫の治療に使用するためのカプサイシノイド |
| US9359316B1 (en) | 2014-11-25 | 2016-06-07 | Concentric Analgesics, Inc. | Prodrugs of phenolic TRPV1 agonists |
| WO2016126540A1 (en) | 2015-02-02 | 2016-08-11 | Enspire Group LLC | Stabilized dialkyl fumarate compositions |
| CA2987517A1 (en) | 2015-05-29 | 2016-12-08 | Sun Pharmaceutical Industries Limited | Oral pharmaceutical composition of isotretinoin |
| CA3254279A1 (en) | 2015-06-03 | 2025-03-18 | Triastek, Inc. | PHARMACEUTICAL FORMS AND RELATED USES |
| WO2017087803A1 (en) | 2015-11-20 | 2017-05-26 | Sorrento Therapeutics, Inc. | Methods for pain treatment using resiniferatoxin |
| EP3405187A4 (en) | 2016-01-22 | 2019-07-31 | Centrexion Therapeutics Corporation | SEQUENCING DOSAGE METHOD FOR CAPSAICN FOR THE TREATMENT OF MORTON NEUROM |
| WO2017147146A1 (en) | 2016-02-23 | 2017-08-31 | Concentric Analgesics, Inc. | Prodrugs of phenolic trpv1 agonists |
| EP3463576A4 (en) | 2016-05-25 | 2020-01-15 | Concentric Analgesics, Inc. | PRODRUGS BY PHENOLIC TRPV1 AGONISTS IN COMBINATION WITH LOCAL ANESTHETIC AND VASOCONSTRICTORS FOR IMPROVED LOCAL ANESTHESIA |
| KR102657458B1 (ko) * | 2016-11-02 | 2024-04-12 | 센트렉시온 테라퓨틱스 코포레이션 | 안정한 수성의 캡사이신 주사 가능한 제형 및 이의 의학적 용도 |
| WO2018217937A1 (en) | 2017-05-24 | 2018-11-29 | Concentric Analgesics, Inc. | Prodrugs of phenolic trpv1 agonists in combination with local anesthetics and vasoconstrictors for improved local anesthesia |
| WO2019018769A1 (en) * | 2017-07-20 | 2019-01-24 | Centrexion Therapeutics Corporation | METHODS AND COMPOSITIONS FOR THE TREATMENT OF PAIN USING CAPSAICINE |
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| US12201594B2 (en) | 2025-01-21 |
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| US20210299072A1 (en) | 2021-09-30 |
| CN111201015A (zh) | 2020-05-26 |
| JP7282736B2 (ja) | 2023-05-29 |
| US20200360314A1 (en) | 2020-11-19 |
| IL272036B2 (en) | 2025-01-01 |
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