CN111201015A - 使用辣椒素治疗疼痛的方法和组合物 - Google Patents

使用辣椒素治疗疼痛的方法和组合物 Download PDF

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Publication number
CN111201015A
CN111201015A CN201880055069.0A CN201880055069A CN111201015A CN 111201015 A CN111201015 A CN 111201015A CN 201880055069 A CN201880055069 A CN 201880055069A CN 111201015 A CN111201015 A CN 111201015A
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CN
China
Prior art keywords
joint
cooling article
knee
capsaicin
skin
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Pending
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CN201880055069.0A
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English (en)
Chinese (zh)
Inventor
J·N·卡姆普贝尔
P·D·汉森
G·F·穆索
D·奥斯托维奇
R·史蒂文
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Centrexion Therapeutics Corp
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Centrexion Therapeutics Corp
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Publication of CN111201015A publication Critical patent/CN111201015A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/10—Cooling bags, e.g. ice-bags
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F2007/0001—Body part
    • A61F2007/0039—Leg or parts thereof
    • A61F2007/0042—Knee

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Thermal Sciences (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Thermotherapy And Cooling Therapy Devices (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medicinal Preparation (AREA)
CN201880055069.0A 2017-07-20 2018-07-20 使用辣椒素治疗疼痛的方法和组合物 Pending CN111201015A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762535003P 2017-07-20 2017-07-20
US62/535,003 2017-07-20
PCT/US2018/043094 WO2019018769A1 (en) 2017-07-20 2018-07-20 METHODS AND COMPOSITIONS FOR THE TREATMENT OF PAIN USING CAPSAICINE

Publications (1)

Publication Number Publication Date
CN111201015A true CN111201015A (zh) 2020-05-26

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CN201880055069.0A Pending CN111201015A (zh) 2017-07-20 2018-07-20 使用辣椒素治疗疼痛的方法和组合物

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US (4) US20200206166A1 (https=)
EP (1) EP3654961B1 (https=)
JP (2) JP7282736B2 (https=)
CN (1) CN111201015A (https=)
AU (1) AU2018302342B2 (https=)
BR (1) BR112020000989A2 (https=)
CA (1) CA3069540A1 (https=)
ES (1) ES3018268T3 (https=)
IL (1) IL272036B2 (https=)
MX (1) MX2020000488A (https=)
WO (1) WO2019018769A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114028540A (zh) * 2021-11-26 2022-02-11 海南鑫开源医药科技有限公司 一种具有镇痛作用的组合物、微针贴片及其制备方法以及应用
CN115006379A (zh) * 2021-12-28 2022-09-06 南京清普生物科技有限公司 一种trpv1激动剂原位膜剂组合物，及其制备方法和用途

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* Cited by examiner, † Cited by third party
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EP3840739B1 (en) * 2018-08-24 2025-11-12 Centrexion Therapeutics Corporation Capsaicin sequential dosing method for treatment of knee joint pain
KR20250075704A (ko) * 2022-09-30 2025-05-28 익스텐드 바이오사이언시즈, 인크. 장기-지속형 부갑상선 호르몬

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114028540A (zh) * 2021-11-26 2022-02-11 海南鑫开源医药科技有限公司 一种具有镇痛作用的组合物、微针贴片及其制备方法以及应用
WO2023092644A1 (zh) * 2021-11-26 2023-06-01 海南鑫开源医药科技有限公司 一种具有镇痛作用的组合物、微针贴片及其制备方法以及应用
CN114028540B (zh) * 2021-11-26 2023-10-17 海南鑫开源医药科技有限公司 一种具有镇痛作用的组合物、微针贴片及其制备方法以及应用
CN115006379A (zh) * 2021-12-28 2022-09-06 南京清普生物科技有限公司 一种trpv1激动剂原位膜剂组合物，及其制备方法和用途
CN115006379B (zh) * 2021-12-28 2023-12-15 南京清普生物科技有限公司 一种trpv1激动剂原位膜剂组合物，及其制备方法和用途

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AU2018302342B2 (en) 2024-08-08
JP2020527574A (ja) 2020-09-10
IL272036B2 (en) 2025-01-01
AU2018302342A1 (en) 2020-02-06
EP3654961A4 (en) 2021-04-21
IL272036A (en) 2020-03-31
CA3069540A1 (en) 2019-01-24
EP3654961A1 (en) 2020-05-27
BR112020000989A2 (pt) 2020-07-14
EP3654961C0 (en) 2025-01-08
WO2019018769A1 (en) 2019-01-24
US20200206166A1 (en) 2020-07-02
US20210299072A1 (en) 2021-09-30
JP7282736B2 (ja) 2023-05-29
US11026903B2 (en) 2021-06-08
US20250312298A1 (en) 2025-10-09
US12201594B2 (en) 2025-01-21
JP2023116457A (ja) 2023-08-22
MX2020000488A (es) 2020-10-28
ES3018268T3 (en) 2025-05-14
JP7738031B2 (ja) 2025-09-11
US20200360314A1 (en) 2020-11-19
IL272036B1 (en) 2024-09-01
EP3654961B1 (en) 2025-01-08

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