BR112019012986A2 - imageamento de tumores e de células imunes com base na expressão de pd-l1 - Google Patents
imageamento de tumores e de células imunes com base na expressão de pd-l1 Download PDFInfo
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- BR112019012986A2 BR112019012986A2 BR112019012986A BR112019012986A BR112019012986A2 BR 112019012986 A2 BR112019012986 A2 BR 112019012986A2 BR 112019012986 A BR112019012986 A BR 112019012986A BR 112019012986 A BR112019012986 A BR 112019012986A BR 112019012986 A2 BR112019012986 A2 BR 112019012986A2
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- Prior art keywords
- fact
- imaging
- cancer
- peptide
- imaging agent
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- 0 C*(**)*(**)*N Chemical compound C*(**)*(**)*N 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0056—Peptides, proteins, polyamino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/14—Peptides, e.g. proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasonic imaging preparations
- A61K49/222—Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/225—Microparticles, microcapsules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Radiology & Medical Imaging (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Acoustics & Sound (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662438575P | 2016-12-23 | 2016-12-23 | |
| US201762519534P | 2017-06-14 | 2017-06-14 | |
| PCT/US2017/068025 WO2018119313A1 (en) | 2016-12-23 | 2017-12-21 | Tumor and immune cell imaging based on pd-l1 expression |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112019012986A2 true BR112019012986A2 (pt) | 2019-12-03 |
Family
ID=62627749
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112019012986A BR112019012986A2 (pt) | 2016-12-23 | 2017-12-21 | imageamento de tumores e de células imunes com base na expressão de pd-l1 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US11607466B2 (https=) |
| EP (1) | EP3558395A4 (https=) |
| JP (3) | JP7784103B2 (https=) |
| KR (2) | KR102662725B1 (https=) |
| CN (1) | CN110366432A (https=) |
| AU (1) | AU2017382282B9 (https=) |
| BR (1) | BR112019012986A2 (https=) |
| CA (1) | CA3048229A1 (https=) |
| IL (1) | IL267572B2 (https=) |
| MX (1) | MX2019007615A (https=) |
| WO (1) | WO2018119313A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY204234A (en) | 2018-08-27 | 2024-08-16 | Regeneron Pharma | Use of raman spectroscopy in downstream purification |
| CN109512798B (zh) * | 2019-01-15 | 2022-05-13 | 南京从一医药科技有限公司 | 一种用于抗肿瘤免疫治疗的药物组合物纳米体系 |
| CN111662270A (zh) * | 2019-03-05 | 2020-09-15 | 中国医学科学院药物研究所 | 碘同位素标记苄苯醚衍生物、及其制法和药物组合物与用途 |
| CN110898234B (zh) * | 2019-12-25 | 2020-12-22 | 河南大学 | 一种二维铋纳米复合材料及其制备方法和应用 |
| TWI833056B (zh) | 2019-12-31 | 2024-02-21 | 財團法人工業技術研究院 | 核酸藥物複合體以及其用途 |
| CN112067586B (zh) * | 2020-06-24 | 2021-08-03 | 江南大学 | 一种基于荧光淬灭拉曼增强的前列腺特异性抗原双信号光谱分析方法 |
| CA3188677A1 (en) * | 2020-08-07 | 2022-02-10 | Sridhar Nimmagadda | Imaging and targeting programmed death ligand-1 (pd-li) expression |
| DE102020130954A1 (de) | 2020-11-23 | 2022-05-25 | Universität Duisburg-Essen | Markierungspartikel für Raman-Streuung und/oder Fluoreszenz-Strahlung |
| CN114853851B (zh) * | 2021-02-04 | 2023-08-15 | 南方医科大学南方医院 | 靶向pd-l1多肽探针及其在制备pet显像剂中的应用 |
| CN113341023B (zh) * | 2021-06-30 | 2022-12-23 | 大连医科大学附属第一医院 | 一种基于液质联用的血清二氨基庚二酸的检测试剂盒及检测方法与应用 |
| WO2023014999A1 (en) * | 2021-08-06 | 2023-02-09 | The Johns Hopkins University | Aluminum fluoride radiosynthesis of [18f]dk222 |
| CN115364247A (zh) * | 2021-09-15 | 2022-11-22 | 中国人民解放军海军军医大学第一附属医院 | 一种靶向显影剂、制备方法及其应用 |
| CN114010655B (zh) * | 2021-11-02 | 2023-02-03 | 安徽医科大学第一附属医院 | 一种识别和降解前列腺癌细胞表面的pd-l1的金纳米星及其制备方法和应用 |
| CN114569745A (zh) * | 2022-03-18 | 2022-06-03 | 哈尔滨医科大学 | 一种靶向pd-l1的多肽pet分子成像探针及其制备方法与应用 |
| AU2024344671A1 (en) * | 2023-09-20 | 2026-03-26 | Trimt Gmbh | Functionalized peptides for in-vivo addressing of pd-l1 expression |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ542371A (en) * | 2003-03-19 | 2008-10-31 | Universitatsspital Basel | Radiolabeled conjugates based on substance P and the uses thereof |
| AU2009333580B2 (en) | 2008-12-09 | 2016-07-07 | Genentech, Inc. | Anti-PD-L1 antibodies and their use to enhance T-cell function |
| WO2012074840A2 (en) * | 2010-11-22 | 2012-06-07 | The General Hospital Corporation | Compositions and methods for in vivo imaging |
| US20140316255A1 (en) * | 2011-09-02 | 2014-10-23 | Ellis Garai | Raman Imaging Devices and Methods of Molecular Imaging |
| US11268958B2 (en) * | 2012-09-14 | 2022-03-08 | The Johns Hopkins University | Bacteria-specific labeled substrtates as imaging biomarkers to diagnose, locate, and monitor infections |
| US9308236B2 (en) | 2013-03-15 | 2016-04-12 | Bristol-Myers Squibb Company | Macrocyclic inhibitors of the PD-1/PD-L1 and CD80(B7-1)/PD-L1 protein/protein interactions |
| TN2017000084A1 (en) * | 2014-09-11 | 2018-07-04 | Bristol Myers Squibb Co | Macrocyclic inhibitors of the pd-1/pd-l1 and cd80 (b7-1)/pd-li protein/protein interactions |
| ES2981335T3 (es) * | 2014-11-25 | 2024-10-08 | Bristol Myers Squibb Co | Novedosos polipéptidos de unión a PD-L1 para obtención de imágenes |
| US9861680B2 (en) | 2014-12-18 | 2018-01-09 | Bristol-Myers Squibb Company | Immunomodulators |
| US9944678B2 (en) | 2014-12-19 | 2018-04-17 | Bristol-Myers Squibb Company | Immunomodulators |
| US20160222060A1 (en) | 2015-02-04 | 2016-08-04 | Bristol-Myers Squibb Company | Immunomodulators |
| HUE054306T2 (hu) * | 2016-05-19 | 2021-08-30 | Bristol Myers Squibb Co | Immunmodulátorok PET-képalkotás számára |
| CN107869033B (zh) * | 2016-09-26 | 2020-10-02 | 青岛胶南海尔洗衣机有限公司 | 一种干衣机用正反转风扇及干衣机 |
-
2017
- 2017-12-21 BR BR112019012986A patent/BR112019012986A2/pt unknown
- 2017-12-21 CA CA3048229A patent/CA3048229A1/en active Pending
- 2017-12-21 MX MX2019007615A patent/MX2019007615A/es unknown
- 2017-12-21 IL IL267572A patent/IL267572B2/en unknown
- 2017-12-21 JP JP2019534737A patent/JP7784103B2/ja active Active
- 2017-12-21 KR KR1020197021481A patent/KR102662725B1/ko active Active
- 2017-12-21 US US16/471,678 patent/US11607466B2/en active Active
- 2017-12-21 KR KR1020247003223A patent/KR20240023665A/ko not_active Ceased
- 2017-12-21 AU AU2017382282A patent/AU2017382282B9/en active Active
- 2017-12-21 WO PCT/US2017/068025 patent/WO2018119313A1/en not_active Ceased
- 2017-12-21 EP EP17883237.4A patent/EP3558395A4/en active Pending
- 2017-12-21 CN CN201780087531.0A patent/CN110366432A/zh active Pending
-
2022
- 2022-12-23 JP JP2022207606A patent/JP7680759B2/ja active Active
-
2025
- 2025-04-30 JP JP2025075768A patent/JP2025118743A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP3558395A4 (en) | 2020-08-12 |
| KR20240023665A (ko) | 2024-02-22 |
| IL267572A (en) | 2019-08-29 |
| US11607466B2 (en) | 2023-03-21 |
| EP3558395A1 (en) | 2019-10-30 |
| AU2017382282B9 (en) | 2025-02-13 |
| JP2020514278A (ja) | 2020-05-21 |
| KR102662725B1 (ko) | 2024-04-30 |
| JP2025118743A (ja) | 2025-08-13 |
| JP7784103B2 (ja) | 2025-12-11 |
| IL267572B1 (en) | 2024-10-01 |
| WO2018119313A1 (en) | 2018-06-28 |
| CN110366432A (zh) | 2019-10-22 |
| JP7680759B2 (ja) | 2025-05-21 |
| US20190314531A1 (en) | 2019-10-17 |
| CA3048229A1 (en) | 2018-06-28 |
| JP2023052071A (ja) | 2023-04-11 |
| IL267572B2 (en) | 2025-02-01 |
| AU2017382282A1 (en) | 2019-07-11 |
| AU2017382282B2 (en) | 2025-01-30 |
| MX2019007615A (es) | 2019-11-05 |
| KR20190102018A (ko) | 2019-09-02 |
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| B350 | Update of information on the portal [chapter 15.35 patent gazette] | ||
| B06W | Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette] |