BR112019008656A8 - Composto de aminopirazolopirimidina usado como inibidor de receptor de tirosina quinase de fator neurotrófico - Google Patents

Composto de aminopirazolopirimidina usado como inibidor de receptor de tirosina quinase de fator neurotrófico

Info

Publication number
BR112019008656A8
BR112019008656A8 BR112019008656A BR112019008656A BR112019008656A8 BR 112019008656 A8 BR112019008656 A8 BR 112019008656A8 BR 112019008656 A BR112019008656 A BR 112019008656A BR 112019008656 A BR112019008656 A BR 112019008656A BR 112019008656 A8 BR112019008656 A8 BR 112019008656A8
Authority
BR
Brazil
Prior art keywords
tyrosine kinase
aminopyrazolopyrimidine
neurotrophic factor
factor receptor
kinase inhibitor
Prior art date
Application number
BR112019008656A
Other languages
English (en)
Other versions
BR112019008656A2 (pt
Inventor
Fansheng Kong
Hong Luo
Hongjiang Xu
Li Zhu
Liguang Dai
Ling Yang
Meng Guo
Shanchun Wang
Wei Wu
Xiaowei Duan
Yanqing Yang
Yinghui Sun
Yong Peng
Yongxin Han
Yuandong Hu
Zhaobai Zhong
Original Assignee
Centaurus Biopharma Co Ltd
Chia Tai Tianqing Pharmaceutical Group Co Ltd
Lianyungang Runzhong Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centaurus Biopharma Co Ltd, Chia Tai Tianqing Pharmaceutical Group Co Ltd, Lianyungang Runzhong Pharmaceutical Co Ltd filed Critical Centaurus Biopharma Co Ltd
Publication of BR112019008656A2 publication Critical patent/BR112019008656A2/pt
Publication of BR112019008656A8 publication Critical patent/BR112019008656A8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

é fornecido um composto de aminopirazolopirimidina conforme representado pela seguinte fórmula estrutural usada como um inibidor de receptor de tirosina quinase de fator neurotrófico. o composto pode inibir a atividade de trk quinase e pode tratar doenças mediadas por um receptor de trk tirosina quinase em mamíferos.
BR112019008656A 2016-10-28 2017-10-27 Composto de aminopirazolopirimidina usado como inibidor de receptor de tirosina quinase de fator neurotrófico BR112019008656A8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201610970314 2016-10-28
CN201710044000 2017-01-21
PCT/CN2017/108100 WO2018077246A1 (zh) 2016-10-28 2017-10-27 用作神经营养因子酪氨酸激酶受体抑制剂的氨基吡唑并嘧啶化合物

Publications (2)

Publication Number Publication Date
BR112019008656A2 BR112019008656A2 (pt) 2019-07-09
BR112019008656A8 true BR112019008656A8 (pt) 2022-06-07

Family

ID=62024344

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112019008656A BR112019008656A8 (pt) 2016-10-28 2017-10-27 Composto de aminopirazolopirimidina usado como inibidor de receptor de tirosina quinase de fator neurotrófico

Country Status (16)

Country Link
US (1) US10829492B2 (pt)
EP (1) EP3533796B1 (pt)
JP (1) JP7046940B2 (pt)
KR (1) KR102616249B1 (pt)
CN (1) CN109890820B (pt)
AU (1) AU2017348826B2 (pt)
BR (1) BR112019008656A8 (pt)
CA (1) CA3041942C (pt)
DK (1) DK3533796T3 (pt)
ES (1) ES2896943T3 (pt)
HU (1) HUE057733T2 (pt)
MX (1) MX2019004847A (pt)
PL (1) PL3533796T3 (pt)
PT (1) PT3533796T (pt)
RU (1) RU2764523C2 (pt)
WO (1) WO2018077246A1 (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019037761A1 (zh) * 2017-08-23 2019-02-28 正大天晴药业集团股份有限公司 含有氨基吡唑并嘧啶的大环化合物及其药物组合物和用途
CN108794370A (zh) * 2018-07-31 2018-11-13 上海弈柯莱生物医药科技有限公司 一种拉罗替尼中间体的制备方法
US20210395256A1 (en) * 2018-12-07 2021-12-23 Betta Pharmaceuticals Co., Ltd. Tyrosine kinase inhibitors, compositions and methods there of
WO2020187291A1 (zh) 2019-03-19 2020-09-24 华中师范大学 吡唑并嘧啶化合物和药物组合物及其应用
CN112979654B (zh) * 2019-12-16 2024-03-19 赛诺哈勃药业（成都）有限公司 杂芳基稠环化合物、其制备方法及应用
CN115551863A (zh) * 2020-06-11 2022-12-30 贝达药业股份有限公司 酪氨酸激酶抑制剂的盐型、晶型、药物组合物及其用途
CN111620881B (zh) * 2020-07-08 2023-03-31 浙江合聚生物医药有限公司 拉罗替尼衍生物及其制备方法和应用
CN113563343B (zh) * 2020-07-27 2022-05-24 杭州邦顺制药有限公司 取代的吡唑并[1,5-a]嘧啶化合物及其用途
CN112010860B (zh) * 2020-08-05 2023-03-10 南京纳丁菲医药科技有限公司 苄氧基吡唑并嘧啶化合物和药物组合物及其应用
CN114437075A (zh) * 2020-11-03 2022-05-06 上海瑶琪生物科技有限公司 用作ntrk激酶抑制剂的化合物及其应用
CN117751121A (zh) * 2021-07-30 2024-03-22 正大天晴药业集团股份有限公司 氨基吡唑并嘧啶化合物的晶体
CN117597129A (zh) * 2021-08-06 2024-02-23 正大天晴药业集团股份有限公司 氨基吡唑并嘧啶化合物在治疗trk激酶介导的肿瘤中的用途
CN117088800B (zh) * 2023-08-18 2024-05-28 龙曦宁（上海）医药科技有限公司 一种5-甲基吡咯烷-3-醇盐酸盐的制备方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10356579A1 (de) * 2003-12-04 2005-07-07 Merck Patent Gmbh Aminderivate
WO2009140128A2 (en) * 2008-05-13 2009-11-19 Irm Llc Compounds and compositions as kinase inhibitors
MX2010014559A (es) 2008-07-01 2011-03-04 Genentech Inc Heterociclos bicíclicos sustituidos y metodos de uso.
RS53350B (en) 2008-09-22 2014-10-31 Array Biopharma, Inc. SUBSTITUTED COMPOUNDS OF IMIDASO [1,2-B] PYRIDASINE AS INK KINASE INHIBITORS
KR101634833B1 (ko) * 2008-10-22 2016-06-29 어레이 바이오파마 인크. ＴＲＫ 키나아제 억제제로서 치환된 피라졸로［１,５­ａ］ 피리미딘 화합물
AR077468A1 (es) * 2009-07-09 2011-08-31 Array Biopharma Inc Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa
WO2012034095A1 (en) * 2010-09-09 2012-03-15 Irm Llc Compounds and compositions as trk inhibitors
CA2828219A1 (en) 2011-02-25 2012-08-30 Irm Llc Pyrazolo [1,5-a] pyridines as trk inhibitors
US9096605B2 (en) * 2011-08-24 2015-08-04 Glaxosmithkline Llc Pyrazolopyrimidine derivatives as PI3 kinase inhibitors
BR112014014276A2 (pt) 2011-12-12 2017-06-13 Dr Reddys Laboratories Ltd composto, composição farmacêutica, método para inibir uma cinase receptora, e, métodos para tratar condições, doenças e/ou distúrbios, e dor
MX353336B (es) * 2013-02-19 2018-01-09 Ono Pharmaceutical Co Compuesto inhibidor de cinasa del receptor de tropomiosina (trk).
WO2014143242A1 (en) * 2013-03-15 2014-09-18 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of atr kinase
CN104650092B (zh) * 2013-11-16 2017-11-10 广东东阳光药业有限公司 取代的杂芳基化合物及其组合物和用途
RU2720408C2 (ru) * 2013-12-06 2020-04-29 Вертекс Фармасьютикалз Инкорпорейтед Способ получения ингибиторов atr киназы (варианты)
CA2971024C (en) * 2014-12-15 2023-09-26 Handok Inc. Fused ring heteroaryl compounds and their use as trk inhibitors

Also Published As

Publication number Publication date
AU2017348826A1 (en) 2019-05-23
JP2019537588A (ja) 2019-12-26
BR112019008656A2 (pt) 2019-07-09
KR20190067913A (ko) 2019-06-17
EP3533796A4 (en) 2020-06-03
PT3533796T (pt) 2021-11-18
RU2764523C2 (ru) 2022-01-18
KR102616249B1 (ko) 2023-12-21
CA3041942C (en) 2023-03-14
CA3041942A1 (en) 2018-05-03
JP7046940B2 (ja) 2022-04-04
US20190352306A1 (en) 2019-11-21
WO2018077246A1 (zh) 2018-05-03
MX2019004847A (es) 2019-08-29
DK3533796T3 (da) 2021-11-08
PL3533796T3 (pl) 2022-01-17
CN109890820A (zh) 2019-06-14
ES2896943T3 (es) 2022-02-28
EP3533796B1 (en) 2021-09-29
US10829492B2 (en) 2020-11-10
HUE057733T2 (hu) 2022-06-28
RU2019114600A (ru) 2020-11-30
CN109890820B (zh) 2020-11-03
AU2017348826B2 (en) 2021-12-02
RU2019114600A3 (pt) 2021-02-20
EP3533796A1 (en) 2019-09-04

Similar Documents

Publication Publication Date Title
BR112019008656A8 (pt) Composto de aminopirazolopirimidina usado como inibidor de receptor de tirosina quinase de fator neurotrófico
BR112017003312A2 (pt) compostos de indazol como inibidores de fgfr quinase, preparação e uso dos mesmos
BR112018069612A2 (pt) compostos de pirroltriazina como inibidores de tam
DOP2016000270A (es) Inhibidores espirocíclicos sustituidos de la autotaxina y su preparación y uso en el tratamiento de enfermedades dependientes o mediadas por lpa
UY37124A (es) Nuevos compuestos de 6,7-dihidro-5h-benzo[7]anuleno sustituidos, procesos para su preparación y usos terapéuticos de los mismos
CU20160188A7 (es) Compuestos de indazole substituidos como inhibidores de irak4
PH12018500041A1 (en) Substituted aza compoounds as irak-4 inhibitors
BR112018074621A2 (pt) derivados de pirazolopirimidina como inibidores de quinase
CR20160523A (es) Compuestos de imidazo[4,5-c]quinolin-2-ona y su uso para tratar cáncer
BR112018010118A2 (pt) inibidores de cxcr2
EA202192151A1 (ru) Применение пиразолпиримидиновых производных для лечения нарушений, связанных с pi3k
UA111075C2 (uk) Триазолопіридинові сполуки як інгібітори кінази рім
CR20150633A (es) Derivados del bipirazol como inhibidores jak
EA201990833A1 (ru) Соединение пиридина
UY35798A (es) Inhibidores del receptor del factor de crecimiento de fibroblastos
EA201690268A1 (ru) Замещенные производные хиназолин-4-она
CO2018007738A2 (es) Derivados de tiohidantoína sustituidos como antagonistas del receptor de andrógenos
BR112018003634A8 (pt) Processo para preparar um inibidor parp, formas cristalinas e usos destes
EA201692143A1 (ru) Производные аминопиразина в качестве ингибиторов фосфатидилинозитол-3-киназы
BR112018014705A2 (pt) inibidores de tirosina quinase de bruton
CL2016001409A1 (es) Inhibidores de quinasa relacionada con la tropomiosina (trk).
BR112016029825A2 (pt) composto
NI201500115A (es) Estra-1,3,5(10), 16-tetraeno-3-carboxamidas para la inhibición de la 17b-hidroxiesteroide deshidrogenasa (akr1 c3)
EA201790687A1 (ru) Хинолинкарбоксамиды для применения в лечении множественной миеломы
ITUB20152967A1 (it) Asse da stiro con piano vaporizzante per uso domestico con varie modalita' di stiratura

Legal Events

Date Code Title Description
B350 Update of information on the portal [chapter 15.35 patent gazette]
B06W Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette]