BR112019007096A2 - método para a detecção de apolipoproteína e4 - Google Patents

método para a detecção de apolipoproteína e4

Info

Publication number
BR112019007096A2
BR112019007096A2 BR112019007096A BR112019007096A BR112019007096A2 BR 112019007096 A2 BR112019007096 A2 BR 112019007096A2 BR 112019007096 A BR112019007096 A BR 112019007096A BR 112019007096 A BR112019007096 A BR 112019007096A BR 112019007096 A2 BR112019007096 A2 BR 112019007096A2
Authority
BR
Brazil
Prior art keywords
apoe4
detecting
sample
apolipoprotein
binder
Prior art date
Application number
BR112019007096A
Other languages
English (en)
Inventor
Bergmann Andreas
Original Assignee
Sphingotec Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sphingotec Gmbh filed Critical Sphingotec Gmbh
Publication of BR112019007096A2 publication Critical patent/BR112019007096A2/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/775—Apolipopeptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

a presente invenção refere-se a um método para a detecção de uma apolipoproteína e isótipo 4 (apoe4) ou seus fragmentos em uma amostra de sangue de um indivíduo, por meio da qual dito mé-todo compreende as etapas de colocar em contato dita amostra com uma fase sólida, colocar em contato dita amostra com pelo menos um aglutinante que se liga especificamente à apoe4 ou um fragmento desta, formando assim um complexo de apoe4-aglutinante, e detectar o complexo de apoe4-aglutinante.
BR112019007096A 2016-10-12 2017-10-12 método para a detecção de apolipoproteína e4 BR112019007096A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16193587.9A EP3309550A1 (en) 2016-10-12 2016-10-12 Method for the detection of apolipoprotein e4
PCT/EP2017/076046 WO2018069437A1 (en) 2016-10-12 2017-10-12 Method for the detection of apolipoprotein e4

Publications (1)

Publication Number Publication Date
BR112019007096A2 true BR112019007096A2 (pt) 2019-06-25

Family

ID=57153320

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112019007096A BR112019007096A2 (pt) 2016-10-12 2017-10-12 método para a detecção de apolipoproteína e4

Country Status (9)

Country Link
US (1) US20210223242A1 (pt)
EP (2) EP3309550A1 (pt)
JP (2) JP2019536007A (pt)
CN (1) CN109891240B (pt)
AU (1) AU2017342043A1 (pt)
BR (1) BR112019007096A2 (pt)
CA (1) CA3039756A1 (pt)
MX (1) MX2019004219A (pt)
WO (1) WO2018069437A1 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112540179B (zh) * 2020-08-06 2023-07-07 武汉天德生物科技有限公司 一种测试ApoE4蛋白含量的ELISA试剂盒
WO2022080207A1 (ja) 2020-10-14 2022-04-21 株式会社島津製作所 遺伝子多型検出方法
CN113419059B (zh) * 2021-06-30 2023-09-01 迈克生物股份有限公司 用于化学发光免疫分析方法的封闭剂

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Also Published As

Publication number Publication date
EP3526605A1 (en) 2019-08-21
US20210223242A1 (en) 2021-07-22
CA3039756A1 (en) 2018-04-19
AU2017342043A1 (en) 2019-04-11
RU2019113771A3 (pt) 2021-02-04
CN109891240A (zh) 2019-06-14
MX2019004219A (es) 2019-06-10
CN109891240B (zh) 2023-06-30
WO2018069437A1 (en) 2018-04-19
EP3309550A1 (en) 2018-04-18
JP2023002599A (ja) 2023-01-10
RU2019113771A (ru) 2020-11-13
JP2019536007A (ja) 2019-12-12
AU2017342043A8 (en) 2019-05-02

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