BR112018008749A2 - métodos de detecção de apolipoproteína - Google Patents

métodos de detecção de apolipoproteína

Info

Publication number
BR112018008749A2
BR112018008749A2 BR112018008749A BR112018008749A BR112018008749A2 BR 112018008749 A2 BR112018008749 A2 BR 112018008749A2 BR 112018008749 A BR112018008749 A BR 112018008749A BR 112018008749 A BR112018008749 A BR 112018008749A BR 112018008749 A2 BR112018008749 A2 BR 112018008749A2
Authority
BR
Brazil
Prior art keywords
detection methods
methods
apolipoprotein
apolipoprotein detection
apolipoproteins
Prior art date
Application number
BR112018008749A
Other languages
English (en)
Other versions
BR112018008749A8 (pt
Inventor
Rodríguez Martín Andrés
García Albert Luis
Calero Lara Miguel
Calero Rueda Olga
Original Assignee
Biocross S L
Centro De Investig Biomedica En Red De Enfermedades Neurodegenerativas
Inst De Salud Carlos Iii
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biocross S L, Centro De Investig Biomedica En Red De Enfermedades Neurodegenerativas, Inst De Salud Carlos Iii filed Critical Biocross S L
Publication of BR112018008749A2 publication Critical patent/BR112018008749A2/pt
Publication of BR112018008749A8 publication Critical patent/BR112018008749A8/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/775—Apolipopeptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2828—Prion diseases
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2835—Movement disorders, e.g. Parkinson, Huntington, Tourette
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/32—Cardiovascular disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/50—Determining the risk of developing a disease

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Ecology (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)

Abstract

a presente invenção refere-se a métodos para a detecção e quantificação de apolipoproteínas e isoformas destas em uma amostra, bem como a métodos previsíveis da probabilidade de desenvolvimento de doença neurodegenerativa ou cardiovascular baseado nos níveis de apolipoproteína, conforme determinados pelos métodos de detecção da invenção.
BR112018008749A 2015-11-02 2016-11-02 métodos de detecção de apolipoproteína BR112018008749A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15382537.7A EP3163303A1 (en) 2015-11-02 2015-11-02 Methods for apolipoprotein detection
PCT/EP2016/076457 WO2017076919A2 (en) 2015-11-02 2016-11-02 Methods for apolipoprotein detection

Publications (2)

Publication Number Publication Date
BR112018008749A2 true BR112018008749A2 (pt) 2018-10-30
BR112018008749A8 BR112018008749A8 (pt) 2019-02-26

Family

ID=54608470

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018008749A BR112018008749A8 (pt) 2015-11-02 2016-11-02 métodos de detecção de apolipoproteína

Country Status (17)

Country Link
US (1) US20180313854A1 (pt)
EP (3) EP3163303A1 (pt)
JP (1) JP6994718B2 (pt)
KR (1) KR102630558B1 (pt)
CN (1) CN108700593A (pt)
AU (1) AU2016348558B2 (pt)
BR (1) BR112018008749A8 (pt)
CA (1) CA3003837A1 (pt)
DK (1) DK3274725T3 (pt)
ES (1) ES2728268T3 (pt)
HU (1) HUE042606T2 (pt)
MX (1) MX2018005448A (pt)
PL (1) PL3274725T3 (pt)
PT (1) PT3274725T (pt)
RU (1) RU2763404C2 (pt)
TR (1) TR201904846T4 (pt)
WO (1) WO2017076919A2 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110234998A (zh) * 2016-07-21 2019-09-13 克利夫兰心脏实验室公司 Hdl相关蛋白质生物标记物组的检测
US20190369113A1 (en) * 2018-06-01 2019-12-05 Laboratory Corporation Of America Holdings Simplified Biosample Processing for LC-MS/MS
CN109212218A (zh) * 2018-11-07 2019-01-15 李玉民 基于apoa4蛋白胃癌检测试剂盒、及其使用方法
WO2021050880A2 (en) * 2019-09-13 2021-03-18 Northwestern University Biomarkers for amyotrophic lateral sclerosis (als) and motor neuron diseases
CN110780071A (zh) * 2019-11-11 2020-02-11 彭涛 一种乙肝相关肝细胞癌的预后检测试剂盒
CN112375138B (zh) * 2020-11-13 2022-12-13 中元汇吉生物技术股份有限公司 一种重组载脂蛋白e和应用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4772549A (en) * 1986-05-30 1988-09-20 Biotechnology Research Partners, Ltd. Polymorphisms related to lipid metabolism: ApoB, ApoCII, ApoE, ApoAIV
US5945289A (en) 1996-12-20 1999-08-31 Lehrer; Steven Method for detecting prostate cancer by apolipoprotein E (Apo-E) genotyping
JP3397066B2 (ja) * 1996-12-27 2003-04-14 富士レビオ株式会社 免疫学的測定方法を用いたアポ蛋白ｅフェノタイプの同定方法
AU762931B2 (en) * 1999-03-16 2003-07-10 Serex, Inc. Method and device for detection of Apo A, Apo B and the ratio thereof in saliva
JP4153873B2 (ja) * 2001-10-04 2008-09-24 株式会社 免疫生物研究所 アルツハイマー危険因子の検出試薬および検出用キットならびにこれらを用いるアルツハイマー危険因子の検出方法
AU2003211022A1 (en) * 2002-02-19 2003-09-09 Ilex Products, Inc. Aminodiphosphonate apolipoprotein e modulators
WO2005072152A2 (en) * 2004-01-22 2005-08-11 Genaissance Pharmaceuticals, Inc. Apoc1 genetic markers associated with age of onset of alzheimer's disease
JP5229789B2 (ja) * 2007-02-27 2013-07-03 プリマハム株式会社 新規ストレスバイオマーカー及びその用途
WO2009108073A1 (en) * 2008-02-28 2009-09-03 Auckland Uniservices Limited Biomarkers for prediction of preeclampsia and/or cardiovascular disease
ES2364169B1 (es) * 2010-02-09 2012-07-10 CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (CSIC) (Titular al 50%) Uso de las isoformas de apo j como biomarcadores de lesión tisular.
EP2542581A4 (en) * 2010-03-01 2014-01-22 David Gladstone Inst SPECIFIC APOLIPOPROTEIN ANTIBODY AND METHODS OF USING SAME
US20120009125A1 (en) * 2010-07-06 2012-01-12 Lombard Jay L Apoe4 and apoj biomarker-based prevention and treatment of dementia
WO2013170057A2 (en) * 2012-05-09 2013-11-14 President And Fellows Of Harvard College Quantification of lipoproteins
EP2770326B1 (en) * 2013-02-26 2019-09-11 Instituto Oftalmologico Fernandez - Vega, S.L. Method for the diagnosis of glaucoma based on the determination of serum protein levels

Also Published As

Publication number Publication date
CA3003837A1 (en) 2017-05-11
RU2763404C2 (ru) 2021-12-28
TR201904846T4 (tr) 2019-04-22
PL3274725T3 (pl) 2019-08-30
CN108700593A (zh) 2018-10-23
AU2016348558B2 (en) 2022-02-24
DK3274725T3 (en) 2019-04-23
US20180313854A1 (en) 2018-11-01
RU2018120081A3 (pt) 2020-03-10
PT3274725T (pt) 2019-04-30
EP3163303A1 (en) 2017-05-03
WO2017076919A2 (en) 2017-05-11
KR102630558B1 (ko) 2024-01-26
EP3274725B1 (en) 2019-01-09
EP3274725A2 (en) 2018-01-31
RU2018120081A (ru) 2019-12-05
JP2018533022A (ja) 2018-11-08
KR20180081545A (ko) 2018-07-16
MX2018005448A (es) 2019-04-04
AU2016348558A1 (en) 2018-06-21
JP6994718B2 (ja) 2022-01-14
ES2728268T3 (es) 2019-10-23
BR112018008749A8 (pt) 2019-02-26
WO2017076919A3 (en) 2017-06-15
EP3457140A1 (en) 2019-03-20
HUE042606T2 (hu) 2019-07-29

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