BR112018073945A2 - métodos para tratamento de miastenia grave generalizada refratária - Google Patents
métodos para tratamento de miastenia grave generalizada refratáriaInfo
- Publication number
- BR112018073945A2 BR112018073945A2 BR112018073945-6A BR112018073945A BR112018073945A2 BR 112018073945 A2 BR112018073945 A2 BR 112018073945A2 BR 112018073945 A BR112018073945 A BR 112018073945A BR 112018073945 A2 BR112018073945 A2 BR 112018073945A2
- Authority
- BR
- Brazil
- Prior art keywords
- myasthenia gravis
- methods
- treating refractory
- generalized myasthenia
- refractory generalized
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 206010028417 myasthenia gravis Diseases 0.000 title abstract 2
- 239000000126 substance Substances 0.000 abstract 2
- 102000014914 Carrier Proteins Human genes 0.000 abstract 1
- 108091008324 binding proteins Proteins 0.000 abstract 1
- 230000000295 complement effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/3496—Plasmapheresis; Leucopheresis; Lymphopheresis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Anesthesiology (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662342321P | 2016-05-27 | 2016-05-27 | |
US62/342,321 | 2016-05-27 | ||
US201662346168P | 2016-06-06 | 2016-06-06 | |
US62/346,168 | 2016-06-06 | ||
US201762489240P | 2017-04-24 | 2017-04-24 | |
US62/489,240 | 2017-04-24 | ||
US201762500643P | 2017-05-03 | 2017-05-03 | |
US62/500,643 | 2017-05-03 | ||
PCT/US2017/032767 WO2017205101A1 (en) | 2016-05-27 | 2017-05-15 | Methods for treatment of refractory generalized myasthenia gravis |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112018073945A2 true BR112018073945A2 (pt) | 2019-02-26 |
Family
ID=60412593
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112018073945-6A BR112018073945A2 (pt) | 2016-05-27 | 2017-05-15 | métodos para tratamento de miastenia grave generalizada refratária |
Country Status (11)
Country | Link |
---|---|
US (2) | US20170342139A1 (pt) |
EP (2) | EP3909609A1 (pt) |
JP (2) | JP2019517473A (pt) |
KR (1) | KR20190012199A (pt) |
CN (1) | CN109475630A (pt) |
AU (1) | AU2017269839A1 (pt) |
BR (1) | BR112018073945A2 (pt) |
CA (1) | CA3024618A1 (pt) |
MX (1) | MX2018014560A (pt) |
RU (1) | RU2018141451A (pt) |
WO (1) | WO2017205101A1 (pt) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA3024618A1 (en) * | 2016-05-27 | 2017-11-30 | Alexion Pharmaceuticals, Inc. | Methods for treatment of refractory generalized myasthenia gravis |
JP7102353B2 (ja) | 2016-06-14 | 2022-07-19 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 抗c5抗体及びそれらの使用 |
WO2019118556A1 (en) | 2017-12-13 | 2019-06-20 | Regeneron Pharmaceuticals, Inc. | Anti-c5 antibody combinations and uses thereof |
JP2022500427A (ja) * | 2018-09-17 | 2022-01-04 | 国立大学法人京都大学 | 肝傷害又は肝不全の処置のための抗c5剤の投与 |
WO2020106724A1 (en) * | 2018-11-20 | 2020-05-28 | Alexion Pharmaceuticals, Inc. | Methods for treatment of refractory generalized myasthenia gravis in pediatric patients |
MX2021009789A (es) * | 2019-02-14 | 2021-11-17 | Alexion Pharma Inc | Dosificacion y administracion de anticuerpos anti-c5 para el tratamiento de miastenia gravis generalizada. |
WO2021026160A1 (en) * | 2019-08-05 | 2021-02-11 | Alexion Pharmaceuticals, Inc. | Methods for treatment of refractory generalized myasthenia gravis with eculizumab |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6074642A (en) | 1994-05-02 | 2000-06-13 | Alexion Pharmaceuticals, Inc. | Use of antibodies specific to human complement component C5 for the treatment of glomerulonephritis |
JP4021194B2 (ja) | 2001-12-28 | 2007-12-12 | シャープ株式会社 | 薄膜トランジスタ装置の製造方法 |
US9415102B2 (en) * | 2002-09-06 | 2016-08-16 | Alexion Pharmaceuticals, Inc. | High concentration formulations of anti-C5 antibodies |
US7807378B2 (en) * | 2005-12-29 | 2010-10-05 | Industrial Technology Research Institute (Itri) | Method of diagnosing myasthenia gravis and kits therefor |
MX2011001371A (es) | 2008-08-05 | 2011-06-16 | Novartis Ag | Composiciones y metodos para anticuerpos que se dirigen a la proteina de complementos c5. |
CN102271703B (zh) * | 2008-11-10 | 2015-09-16 | 阿雷克森制药公司 | 用于治疗补体相关障碍的方法和组合物 |
TWI838039B (zh) | 2011-03-28 | 2024-04-01 | 法商賽諾菲公司 | 具有交叉結合區定向之雙重可變區類抗體結合蛋白 |
NZ631007A (en) | 2014-03-07 | 2015-10-30 | Alexion Pharma Inc | Anti-c5 antibodies having improved pharmacokinetics |
CA3024618A1 (en) * | 2016-05-27 | 2017-11-30 | Alexion Pharmaceuticals, Inc. | Methods for treatment of refractory generalized myasthenia gravis |
US20190328854A1 (en) * | 2016-08-29 | 2019-10-31 | The Cleveland Clinic Foundation | C5 immunization for autologous anti-c5 antibody production |
-
2017
- 2017-05-15 CA CA3024618A patent/CA3024618A1/en not_active Abandoned
- 2017-05-15 RU RU2018141451A patent/RU2018141451A/ru not_active Application Discontinuation
- 2017-05-15 US US15/595,890 patent/US20170342139A1/en not_active Abandoned
- 2017-05-15 EP EP21159097.1A patent/EP3909609A1/en active Pending
- 2017-05-15 BR BR112018073945-6A patent/BR112018073945A2/pt not_active IP Right Cessation
- 2017-05-15 WO PCT/US2017/032767 patent/WO2017205101A1/en unknown
- 2017-05-15 AU AU2017269839A patent/AU2017269839A1/en not_active Abandoned
- 2017-05-15 KR KR1020187037479A patent/KR20190012199A/ko unknown
- 2017-05-15 JP JP2018562058A patent/JP2019517473A/ja active Pending
- 2017-05-15 EP EP17803293.4A patent/EP3463461A4/en not_active Withdrawn
- 2017-05-15 MX MX2018014560A patent/MX2018014560A/es unknown
- 2017-05-15 CN CN201780045437.9A patent/CN109475630A/zh active Pending
-
2021
- 2021-01-15 US US17/150,005 patent/US20210246196A1/en active Pending
-
2022
- 2022-06-22 JP JP2022100008A patent/JP2022126773A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
JP2019517473A (ja) | 2019-06-24 |
EP3463461A1 (en) | 2019-04-10 |
US20210246196A1 (en) | 2021-08-12 |
RU2018141451A3 (pt) | 2020-09-21 |
MX2018014560A (es) | 2019-08-12 |
CN109475630A (zh) | 2019-03-15 |
EP3463461A4 (en) | 2020-05-20 |
CA3024618A1 (en) | 2017-11-30 |
JP2022126773A (ja) | 2022-08-30 |
RU2018141451A (ru) | 2020-06-29 |
WO2017205101A1 (en) | 2017-11-30 |
KR20190012199A (ko) | 2019-02-08 |
US20170342139A1 (en) | 2017-11-30 |
EP3909609A1 (en) | 2021-11-17 |
AU2017269839A1 (en) | 2018-11-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
|
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B350 | Update of information on the portal [chapter 15.35 patent gazette] | ||
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 5A ANUIDADE. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2670 DE 08-03-2022 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |