BR112018075920A2 - dispositivo e métodos de cultura celular - Google Patents
dispositivo e métodos de cultura celularInfo
- Publication number
- BR112018075920A2 BR112018075920A2 BR112018075920-1A BR112018075920A BR112018075920A2 BR 112018075920 A2 BR112018075920 A2 BR 112018075920A2 BR 112018075920 A BR112018075920 A BR 112018075920A BR 112018075920 A2 BR112018075920 A2 BR 112018075920A2
- Authority
- BR
- Brazil
- Prior art keywords
- cell culture
- microfluidic
- culture methods
- culture devices
- devices
- Prior art date
Links
- 238000004113 cell culture Methods 0.000 title abstract 3
- 210000004027 cell Anatomy 0.000 abstract 2
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 abstract 1
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 230000004888 barrier function Effects 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 210000002744 extracellular matrix Anatomy 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000002792 vascular Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/02—Form or structure of the vessel
- C12M23/16—Microfluidic devices; Capillary tubes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M21/00—Bioreactors or fermenters specially adapted for specific uses
- C12M21/08—Bioreactors or fermenters specially adapted for specific uses for producing artificial tissue or for ex-vivo cultivation of tissue
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/02—Form or structure of the vessel
- C12M23/12—Well or multiwell plates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/38—Caps; Covers; Plugs; Pouring means
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/069—Vascular Endothelial cells
- C12N5/0691—Vascular smooth muscle cells; 3D culture thereof, e.g. models of blood vessels
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/04—Closures and closing means
- B01L2300/041—Connecting closures to device or container
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0848—Specific forms of parts of containers
- B01L2300/0858—Side walls
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/999—Small molecules not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/28—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from vascular endothelial cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2531/00—Microcarriers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/30—Synthetic polymers
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Sustainable Development (AREA)
- Clinical Laboratory Science (AREA)
- Dispersion Chemistry (AREA)
- Cell Biology (AREA)
- Vascular Medicine (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL2016965 | 2016-06-15 | ||
| NL2016965A NL2016965B1 (en) | 2016-06-15 | 2016-06-15 | Cell culture device. |
| NL2018033 | 2016-12-21 | ||
| NL2018033 | 2016-12-21 | ||
| PCT/EP2017/064302 WO2017216113A2 (en) | 2016-06-15 | 2017-06-12 | Cell culture device and methods |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112018075920A2 true BR112018075920A2 (pt) | 2019-03-26 |
Family
ID=59215734
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112018075920-1A BR112018075920A2 (pt) | 2016-06-15 | 2017-06-12 | dispositivo e métodos de cultura celular |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US11629319B2 (enExample) |
| EP (1) | EP3472301B1 (enExample) |
| JP (1) | JP6967535B2 (enExample) |
| CN (1) | CN109804057B (enExample) |
| AU (1) | AU2017286096B2 (enExample) |
| BR (1) | BR112018075920A2 (enExample) |
| CA (1) | CA3027616A1 (enExample) |
| RU (1) | RU2741806C2 (enExample) |
| WO (1) | WO2017216113A2 (enExample) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11760965B2 (en) | 2017-10-19 | 2023-09-19 | Georgia Tech Research Corporation | Mesofluidic device for culture of cell aggregates |
| NL2020518B1 (en) | 2018-03-02 | 2019-09-12 | Mimetas B V | Device and method for performing electrical measurements |
| CN108486035B (zh) * | 2018-03-26 | 2021-11-26 | 西北大学 | 一种三维类器官的液滴培养方法 |
| NL2022085B1 (en) * | 2018-11-28 | 2020-06-25 | Mimetas B V | Device for assessing mechanical strain induced in or by cells |
| KR102209346B1 (ko) * | 2019-03-13 | 2021-01-29 | 재단법인대구경북과학기술원 | 미세관통막 기반의 수화젤 마이크로웰 어레이 및 이를 이용한 3차원 단일세포 분리 및 배양방법 |
| US12024696B2 (en) * | 2019-05-08 | 2024-07-02 | Molecular Devices (Austria) GmbH | System and method for organoid culture |
| US20220238042A1 (en) * | 2019-05-10 | 2022-07-28 | Oregon Health & Science University | Engineered bone marrow model |
| AU2020283390A1 (en) * | 2019-05-28 | 2021-12-23 | Duke University | Methods and apparatuses for patient-derived micro-organospheres |
| KR102233992B1 (ko) * | 2019-06-28 | 2021-03-29 | 건양대학교 산학협력단 | 면역화학진단 세포 칩 구조체 |
| WO2021040874A1 (en) * | 2019-08-28 | 2021-03-04 | Massachusetts Institute Of Technology | In vitro tissue plate |
| CN110564674B (zh) * | 2019-09-29 | 2021-05-11 | 广东工业大学 | 一种干细胞铺底工作液及其应用 |
| CN114585746A (zh) * | 2019-10-17 | 2022-06-03 | 公立大学法人横滨市立大学 | 药物毒性评价方法 |
| NL2024202B1 (en) * | 2019-11-08 | 2021-07-20 | Mimetas B V | Microfluidic cell culture system |
| WO2021113924A1 (en) * | 2019-12-12 | 2021-06-17 | The Walter And Eliza Hall Institute Of Medical Research | Organoid cultures |
| EP3907007A1 (de) | 2020-05-08 | 2021-11-10 | Technische Universität Wien | Mikrofluidische vorrichtung |
| US20210394177A1 (en) * | 2020-06-19 | 2021-12-23 | The Texas A&M University System | Systems and methods for mimicking a blood vessel of a patient |
| NL2026038B1 (en) * | 2020-07-09 | 2022-03-15 | Mimetas B V | Microfluidic cell culture device |
| CN112143642B (zh) * | 2020-08-28 | 2022-06-14 | 上海交通大学 | 用于体外培养的血管化肿瘤微流控器官芯片及其制备方法 |
| CA3173455A1 (en) | 2020-09-04 | 2022-03-10 | 9493662 Canada Inc. | Multi-well device, kits and methods for analysis of cells |
| EP3998332A4 (en) * | 2020-09-30 | 2022-09-28 | Beijing Daxiang Biotech Co., Ltd | 3D MULTIORGAN COCULTURE CHIP |
| JP7565008B2 (ja) * | 2020-10-07 | 2024-10-10 | ウシオ電機株式会社 | マイクロ流体デバイス及びマイクロ流体デバイスの使用方法 |
| WO2022087382A1 (en) * | 2020-10-22 | 2022-04-28 | The Board Of Regents Of The University Of Texas System | High throughput cell migration assay plates and methods of fabrication |
| US20220127553A1 (en) * | 2020-10-22 | 2022-04-28 | Molecular Devices (Austria) GmbH | Microplates for automating organoid cultivation |
| CN112358966B (zh) * | 2020-10-23 | 2022-03-22 | 上海交通大学 | 一种滑动式微流控器官芯片及其制备方法 |
| EP4255633A1 (en) * | 2020-12-01 | 2023-10-11 | Agency for Science, Technology and Research | A device and method for vascularising a cell aggregate |
| US20240076593A1 (en) * | 2021-02-19 | 2024-03-07 | Molecular Devices (Austria) GmbH | Methods for organoid passaging using microplate well units |
| KR20230156765A (ko) * | 2021-03-16 | 2023-11-14 | 에이전시 포 사이언스, 테크놀로지 앤드 리서치 | 3d 세포 배양 및 인 비트로 조직 모델을 위한 웰 인서트 및 장치 |
| JP2024513007A (ja) * | 2021-04-09 | 2024-03-21 | セルアートジェン インコーポレイテッド | 細胞集合体の培養のための微細流体の懸滴培養デバイス |
| US12480079B2 (en) | 2021-04-23 | 2025-11-25 | Massachusetts Institute Of Technology | Fluidic platforms for perfusable vascularized tissues with infiltrates |
| CN113755328A (zh) * | 2021-09-08 | 2021-12-07 | 中山大学 | 一种类器官培养装置及类器官培养方法 |
| EP4423234A1 (en) | 2021-10-29 | 2024-09-04 | Universität Bern | Microfluidic cell culturing device |
| USD1028280S1 (en) | 2021-12-27 | 2024-05-21 | Molecular Devices (Austria) GmbH | Organoid microplate |
| US12544754B2 (en) | 2022-01-18 | 2026-02-10 | Molecular Devices (Austria) GmbH | 3D printing of organoid passaging plate |
| US12360102B2 (en) | 2022-01-28 | 2025-07-15 | Glaxosmithkline Intellectual Property Development Limited | High-throughput assay for cell migration, chemotaxis, and function |
| CN114591836A (zh) * | 2022-02-18 | 2022-06-07 | 清华大学深圳国际研究生院 | 体外血管床微流控芯片及其应用 |
| EP4493670A1 (en) * | 2022-03-18 | 2025-01-22 | Molecular Devices (Austria) GmbH | Cell culture application methods of using a separation well microplate |
| WO2023183734A1 (en) * | 2022-03-21 | 2023-09-28 | Molecular Devices (Austria) GmbH | Systems and methods for co-culture in microplates |
| WO2023218024A1 (en) * | 2022-05-13 | 2023-11-16 | Ecole Polytechnique Federale De Lausanne (Epfl) | System for automated and dynamic cell culture |
| US20230383225A1 (en) * | 2022-05-27 | 2023-11-30 | University Of Utah Research Foundation | Lung-on-chip device with integrated extracellular matrix membrane |
| DE102022209416B3 (de) * | 2022-09-09 | 2023-12-21 | Robert Bosch Gesellschaft mit beschränkter Haftung | Mikrofluidische Vorrichtung |
| WO2024129942A1 (en) * | 2022-12-14 | 2024-06-20 | President And Fellows Of Harvard College | Organoids in extracellular matrix droplets |
| DE102023200837A1 (de) * | 2023-02-02 | 2024-08-08 | Carl Zeiss Ag | Probengefäß zur Kultivierung biologischer Proben, Vorrichtung zu dessen Betrieb und Mikroskop |
| WO2024182622A1 (en) * | 2023-03-01 | 2024-09-06 | Research Institute At Nationwide Children's Hospital | Systems, devices, and processes for miniaturized physiological mimicry |
| NL2034328B1 (en) | 2023-03-13 | 2024-09-24 | Mimetas B V | Liver vasculature |
| WO2024191299A1 (en) | 2023-03-13 | 2024-09-19 | Mimetas B.V. | Liver vasculature |
| CN117586876B (zh) * | 2023-10-07 | 2024-10-25 | 丹望医疗科技(上海)有限公司 | 一种血管化类器官芯片及血管化类器官 |
| WO2025080829A1 (en) * | 2023-10-10 | 2025-04-17 | The Trustees Of The University Of Pennsylvania | A model of the blood-brain barrier on a chip |
| AU2024402761A1 (en) * | 2023-12-21 | 2026-04-30 | F. Hoffmann-La Roche Ag | Cell culturing device |
| WO2025186340A1 (de) * | 2024-03-05 | 2025-09-12 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Vorrichtung zum erzeugen von drei-dimensionalen zellstrukturen in einem hydrogel, mikrosystem und/oder mikrofluidische zellkulturplattform und verfahren zum herstellen der vorrichtung |
| CN118374350A (zh) * | 2024-04-15 | 2024-07-23 | 丹望医疗科技(上海)有限公司 | 血管化类器官芯片及其应用 |
| CN118086053B (zh) * | 2024-04-29 | 2024-07-09 | 四川迪亚生物科技集团有限公司 | 一种自灌流培养板及使用方法 |
| TR2024007044A1 (tr) * | 2024-06-04 | 2025-12-22 | Izmir Yueksek Teknoloji Enstituesue Rektoerluegue | 2 ve 3 boyutlu hücre ve doku kültürünleri̇nde kullanilmak üzere üstü açik bi̇r mi̇krofi̇zyoloji̇k si̇stem ve bu si̇stemi̇n çalişma yöntemi̇ |
| GB202409293D0 (en) | 2024-06-27 | 2024-08-14 | Momo Biotech Ltd | Device |
| CN120591192A (zh) * | 2024-07-15 | 2025-09-05 | 苏州先觉生物科技有限公司 | 一种基于牺牲材料的3d细胞培养体的制备方法、3d细胞培养体及应用 |
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| EP2811012A1 (en) | 2013-06-07 | 2014-12-10 | Eidgenossisch Technische Hochschule Zürich | Hanging network plate |
| CN114134042A (zh) * | 2013-09-05 | 2022-03-04 | 伯尔尼大学 | 用于体内器官组织的体外模型化的装置 |
| GB2583047B (en) | 2013-12-20 | 2021-03-24 | Harvard College | Organomimetic devices and methods of use and manufacturing thereof |
| EP3218714A4 (en) * | 2014-11-10 | 2018-07-04 | The Government of the United States of America as represented by the Secretary of the Navy | Modular microtube network for vascularized organ-on-a-chip models |
| WO2016081751A1 (en) * | 2014-11-19 | 2016-05-26 | Nortis, Inc. | Method for vascularizing in-vitro generated or ex-vivo tissue fragments in a microfluidic device |
| RU2584598C1 (ru) * | 2015-03-27 | 2016-05-20 | Общество с ограниченной ответственностью Научно-технический центр "БиоКлиникум" | Микрофлюидный чип для создания клеточных моделей органов млекопитающих |
| CN104877905A (zh) | 2015-05-04 | 2015-09-02 | 清华大学深圳研究生院 | 细胞体外共培养微流控芯片、系统及方法 |
| NL2014840B1 (en) * | 2015-05-21 | 2017-01-31 | Intecrypt B V | Microfluidic device for in vitro 3D cell culture experimentation. |
| WO2016195480A1 (en) | 2015-06-05 | 2016-12-08 | Mimetas B.V. | Microfluidic plate |
-
2017
- 2017-06-12 JP JP2018565659A patent/JP6967535B2/ja active Active
- 2017-06-12 AU AU2017286096A patent/AU2017286096B2/en active Active
- 2017-06-12 BR BR112018075920-1A patent/BR112018075920A2/pt not_active Application Discontinuation
- 2017-06-12 CA CA3027616A patent/CA3027616A1/en active Pending
- 2017-06-12 EP EP17732821.8A patent/EP3472301B1/en active Active
- 2017-06-12 US US16/309,298 patent/US11629319B2/en active Active
- 2017-06-12 RU RU2019100603A patent/RU2741806C2/ru active
- 2017-06-12 CN CN201780045603.5A patent/CN109804057B/zh active Active
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|---|---|
| RU2019100603A (ru) | 2020-07-15 |
| US11629319B2 (en) | 2023-04-18 |
| WO2017216113A3 (en) | 2018-02-01 |
| EP3472301C0 (en) | 2023-08-02 |
| JP6967535B2 (ja) | 2021-11-17 |
| EP3472301A2 (en) | 2019-04-24 |
| CN109804057B (zh) | 2022-09-09 |
| US20200063081A1 (en) | 2020-02-27 |
| JP2019517808A (ja) | 2019-06-27 |
| CA3027616A1 (en) | 2017-12-21 |
| AU2017286096B2 (en) | 2022-01-20 |
| RU2019100603A3 (enExample) | 2020-08-12 |
| CN109804057A (zh) | 2019-05-24 |
| AU2017286096A1 (en) | 2019-01-17 |
| RU2741806C2 (ru) | 2021-01-28 |
| EP3472301B1 (en) | 2023-08-02 |
| WO2017216113A2 (en) | 2017-12-21 |
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