BR112018075347A2 - ligantes de degradadores de receptor androgênico seletivos (sard) e métodos de uso dos mesmos - Google Patents

ligantes de degradadores de receptor androgênico seletivos (sard) e métodos de uso dos mesmos

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Publication number
BR112018075347A2
BR112018075347A2 BR112018075347-5A BR112018075347A BR112018075347A2 BR 112018075347 A2 BR112018075347 A2 BR 112018075347A2 BR 112018075347 A BR112018075347 A BR 112018075347A BR 112018075347 A2 BR112018075347 A2 BR 112018075347A2
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BR
Brazil
Prior art keywords
androgen receptor
air
prostate cancer
sard
methods
Prior art date
Application number
BR112018075347-5A
Other languages
English (en)
Inventor
Narayanan Ramesh
Miller Duane
PONNUSAMY Thamarai
Hwang Dong-Jin
He Yali
Original Assignee
University Of Tennessee Research Foundation
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Publication date
Application filed by University Of Tennessee Research Foundation filed Critical University Of Tennessee Research Foundation
Publication of BR112018075347A2 publication Critical patent/BR112018075347A2/pt

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    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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Abstract

a presente invenção refere-se a compostos degradores de receptor androgênico seletivos à base de em pirrol, pirazol, imidazol, triazol e morfolina (sard) que incluem anéis de anilida heterocíclicos e seus precursores sintéticos, isômeros r e propanamidas não hidroxiladas e/ou não quirais, e composições farmacêuticas e usos das mesmas no tratamento de câncer de próstata, câncer de próstata avançado, câncer de próstata resistente à castração, câncer de mama triplo negativo, outros cânceres que expressam o receptor androgênico, alopecia androgênica ou outras doenças dérmicas hiperandrogênicas, doença de kennedy, esclerose lateral amiotrófica (ela) aneurisma da aorta (aaa) e fibroides uterinos e a métodos para reduzir os níveis de comprimento de receptor total de andrógeno (ar-fl), que inclui mutações patogênicas ou de resistência, variantes de splice de ar (ar-sv) e polimorfismos de poliglutamina patogênica (poliq) do ar em um indivíduo.
BR112018075347-5A 2016-06-10 2017-06-12 ligantes de degradadores de receptor androgênico seletivos (sard) e métodos de uso dos mesmos BR112018075347A2 (pt)

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