BR112018071584A2 - métodos para modular de maneira seletiva a ativida-de de subtipos distintos de células - Google Patents

métodos para modular de maneira seletiva a ativida-de de subtipos distintos de células

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Publication number
BR112018071584A2
BR112018071584A2 BR112018071584-0A BR112018071584A BR112018071584A2 BR 112018071584 A2 BR112018071584 A2 BR 112018071584A2 BR 112018071584 A BR112018071584 A BR 112018071584A BR 112018071584 A2 BR112018071584 A2 BR 112018071584A2
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Brazil
Prior art keywords
activity
particles
methods
retroviral vectors
distinct cell
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BR112018071584-0A
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English (en)
Inventor
Costa Fejoz Caroline
Verhoeyen Els
Cosset François-Loic
Bender Ruben
Buchholz Christian
Zhou Qin
Original Assignee
Ecole Normale Superieure De Lyon
Centre National De La Recherche Scientifique
Université Claude Bernard Lyon 1
Institut National De La Sante Et De La Recherche Medicale (Inserm)
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Application filed by Ecole Normale Superieure De Lyon, Centre National De La Recherche Scientifique, Université Claude Bernard Lyon 1, Institut National De La Sante Et De La Recherche Medicale (Inserm) filed Critical Ecole Normale Superieure De Lyon
Publication of BR112018071584A2 publication Critical patent/BR112018071584A2/pt

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Abstract

a presente invenção refere-se a partículas do tipo retrovírus pseudotipadas ou vetores retrovirais que compreendem tanto as glicoproteínas do envelope modificadas derivadas de um vírus da família paramyxoviridae fundidas a um domínio alvo da célula e fundidas com um domínio funcional. a presente invenção também se refere ao uso das referidas partículas do tipo retrovírus pseudotipadas ou vetores retrovirais para modular de maneira seletiva a atividade de subconjuntos específicos de células, em particular de células imune específicas. estas partículas do tipo retrovírus pseudotipadas ou vetores retrovirais são particularmente úteis para terapia do gene, terapia imune e/ou vacinação.
BR112018071584-0A 2016-04-21 2017-04-20 métodos para modular de maneira seletiva a ativida-de de subtipos distintos de células BR112018071584A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16305468.7 2016-04-21
EP16305468.7A EP3235908A1 (en) 2016-04-21 2016-04-21 Methods for selectively modulating the activity of distinct subtypes of cells
PCT/EP2017/059435 WO2017182585A1 (en) 2016-04-21 2017-04-20 Methods for selectively modulating the activity of distinct subtypes of cells

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BR112018071584A2 true BR112018071584A2 (pt) 2019-03-12

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US (2) US11608509B2 (pt)
EP (3) EP3235908A1 (pt)
JP (4) JP7412885B2 (pt)
KR (1) KR20190046713A (pt)
CN (2) CN109642243A (pt)
AU (3) AU2017253364B2 (pt)
BR (1) BR112018071584A2 (pt)
CA (1) CA3021549A1 (pt)
EA (1) EA201892369A1 (pt)
ES (1) ES2961976T3 (pt)
IL (1) IL262458A (pt)
MX (2) MX2018012814A (pt)
SG (1) SG11201809164TA (pt)
WO (1) WO2017182585A1 (pt)
ZA (1) ZA201807161B (pt)

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