BR112018070033A2 - preparação enzimática, método para produzir um produto de pancreatina, composição farmacêutica e método para tratar insuficiência pancreática exócrina - Google Patents
preparação enzimática, método para produzir um produto de pancreatina, composição farmacêutica e método para tratar insuficiência pancreática exócrinaInfo
- Publication number
- BR112018070033A2 BR112018070033A2 BR112018070033A BR112018070033A BR112018070033A2 BR 112018070033 A2 BR112018070033 A2 BR 112018070033A2 BR 112018070033 A BR112018070033 A BR 112018070033A BR 112018070033 A BR112018070033 A BR 112018070033A BR 112018070033 A2 BR112018070033 A2 BR 112018070033A2
- Authority
- BR
- Brazil
- Prior art keywords
- producing
- pharmaceutical composition
- enzyme preparation
- exocrine pancreatic
- pancreatic insufficiency
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 238000002360 preparation method Methods 0.000 title abstract 2
- 108090000790 Enzymes Proteins 0.000 title 1
- 102000004190 Enzymes Human genes 0.000 title 1
- 108010019160 Pancreatin Proteins 0.000 title 1
- 229940088598 enzyme Drugs 0.000 title 1
- 201000007089 exocrine pancreatic insufficiency Diseases 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 229940055695 pancreatin Drugs 0.000 title 1
- 229940079919 digestives enzyme preparation Drugs 0.000 abstract 3
- 230000002255 enzymatic effect Effects 0.000 abstract 1
- 210000000496 pancreas Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/54—Mixtures of enzymes or proenzymes covered by more than a single one of groups A61K38/44 - A61K38/46 or A61K38/51 - A61K38/53
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
- A61L2/08—Radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/18—Carboxylic ester hydrolases (3.1.1)
- C12N9/20—Triglyceride splitting, e.g. by means of lipase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/94—Pancreatin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/01—Carboxylic ester hydrolases (3.1.1)
- C12Y301/01003—Triacylglycerol lipase (3.1.1.3)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
a presente invenção refere-se a uma preparação enzimática obtida a partir de tecido animal irradiado com feixe-e, tal como pâncreas suíno. a presente invenção também se refere aos métodos para preparar tais preparações de enzimas, composições farmacêuticas compreendendo tais preparações de enzimas, e métodos para uso de tais composições farmacêuticas e preparações de enzimas.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662314048P | 2016-03-28 | 2016-03-28 | |
US201762452746P | 2017-01-31 | 2017-01-31 | |
US201762454184P | 2017-02-03 | 2017-02-03 | |
PCT/US2017/024315 WO2017172619A1 (en) | 2016-03-28 | 2017-03-27 | Enzyme compositions with reduced viral and microbial contamination |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112018070033A2 true BR112018070033A2 (pt) | 2019-02-05 |
Family
ID=58639038
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112018070033A BR112018070033A2 (pt) | 2016-03-28 | 2017-03-27 | preparação enzimática, método para produzir um produto de pancreatina, composição farmacêutica e método para tratar insuficiência pancreática exócrina |
Country Status (7)
Country | Link |
---|---|
US (2) | US20170274055A1 (pt) |
EP (1) | EP3436055B1 (pt) |
CN (2) | CN109475610A (pt) |
BR (1) | BR112018070033A2 (pt) |
PL (1) | PL3436055T3 (pt) |
PT (1) | PT3436055T (pt) |
WO (1) | WO2017172619A1 (pt) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11278603B2 (en) | 2016-03-28 | 2022-03-22 | Abbvie Inc. | Enzyme compositions with reduced viral and microbial contamination |
CN111630164A (zh) * | 2017-09-27 | 2020-09-04 | 雅培制药股份有限公司 | 具有减少的病毒和微生物污染的酶组合物 |
JP2021506931A (ja) * | 2017-12-20 | 2021-02-22 | クック リージェンテック エルエルシーCook Regentec Llc | 病原体減少血小板組成物および関連方法 |
US20230138700A1 (en) * | 2020-03-30 | 2023-05-04 | Jai WALL | Combined animal-derived and synthetically produced pancreatic enzyme replacement therapy |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3377506D1 (en) | 1982-12-30 | 1988-09-01 | Nordmark Arzneimittel Gmbh | Process for obtaining pancreatin |
US4652763A (en) * | 1985-03-29 | 1987-03-24 | Energy Sciences, Inc. | Electron-beam irradiation sterilization process |
US20030012687A1 (en) * | 2000-03-23 | 2003-01-16 | Macphee Martin J. | Methods of sterilizing biological materials |
US6749851B2 (en) * | 2001-08-31 | 2004-06-15 | Clearant, Inc. | Methods for sterilizing preparations of digestive enzymes |
US20060011376A1 (en) * | 2004-07-16 | 2006-01-19 | General Electric Company | Multi-axial electrically conductive cable with multi-layered core and method of manufacture and use |
AU2006274835B2 (en) | 2005-07-29 | 2012-05-24 | Abbott Laboratories Gmbh | Processes for the manufacture of sterilized pancreatin powder |
US9198871B2 (en) | 2005-08-15 | 2015-12-01 | Abbott Products Gmbh | Delayed release pancreatin compositions |
DE202008003806U1 (de) | 2007-09-14 | 2009-02-12 | Nordmark Arzneimittel Gmbh & Co. Kg | Extrakt für die Herstellung von pharmazeutischen Therapeutika und dessen Verwendung als Nahrungs- oder Lebensmittel oder Nahrungsergänzungsmittel |
ES2385958T3 (es) * | 2008-11-03 | 2012-08-06 | Nordmark Arzneimittel Gmbh & Co.Kg | Procedimiento para reducir la carga viral y microbiana de pancreatina |
CN101757616B (zh) * | 2008-11-18 | 2012-10-31 | 上海松力生物技术有限公司 | 一种安全的冻干哺乳动物源凝血酶制剂及其制备方法 |
RU2012142140A (ru) * | 2010-03-19 | 2014-04-27 | Апталис Фарма Кэнэда Инк. | Бета-пропиолактон для инактивации вирусов в фармацевтических препаратах фермента поджелудочной железы |
EP3024479B2 (en) * | 2013-07-22 | 2023-02-08 | Allergan Pharmaceuticals International Limited | Methods of preparing pancreatin |
-
2017
- 2017-03-27 WO PCT/US2017/024315 patent/WO2017172619A1/en active Application Filing
- 2017-03-27 US US15/470,386 patent/US20170274055A1/en not_active Abandoned
- 2017-03-27 EP EP17719952.8A patent/EP3436055B1/en active Active
- 2017-03-27 CN CN201780032808.XA patent/CN109475610A/zh active Pending
- 2017-03-27 BR BR112018070033A patent/BR112018070033A2/pt unknown
- 2017-03-27 PT PT177199528T patent/PT3436055T/pt unknown
- 2017-03-27 CN CN202211238216.2A patent/CN115737790A/zh active Pending
- 2017-03-27 PL PL17719952.8T patent/PL3436055T3/pl unknown
-
2019
- 2019-03-06 US US16/294,282 patent/US20190201502A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20170274055A1 (en) | 2017-09-28 |
PT3436055T (pt) | 2024-01-29 |
WO2017172619A1 (en) | 2017-10-05 |
CN115737790A (zh) | 2023-03-07 |
CN109475610A (zh) | 2019-03-15 |
EP3436055B1 (en) | 2023-10-25 |
EP3436055A1 (en) | 2019-02-06 |
PL3436055T3 (pl) | 2024-05-06 |
US20190201502A1 (en) | 2019-07-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B25D | Requested change of name of applicant approved |
Owner name: ABBOTT LABORATORIES GMBH (DE) ; ABBOTT GMBH (DE) |
|
B350 | Update of information on the portal [chapter 15.35 patent gazette] | ||
B06W | Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette] |