BR112018003779A2 - sialil-di-lewis a conforme expresso em glicoproteínas, mas não glicolipídios, como um alvo de câncer funcional e anticorpos para o mesmo - Google Patents
sialil-di-lewis a conforme expresso em glicoproteínas, mas não glicolipídios, como um alvo de câncer funcional e anticorpos para o mesmoInfo
- Publication number
- BR112018003779A2 BR112018003779A2 BR112018003779-6A BR112018003779A BR112018003779A2 BR 112018003779 A2 BR112018003779 A2 BR 112018003779A2 BR 112018003779 A BR112018003779 A BR 112018003779A BR 112018003779 A2 BR112018003779 A2 BR 112018003779A2
- Authority
- BR
- Brazil
- Prior art keywords
- sialyl
- glycolipids
- glycoproteins
- lewis
- antibodies
- Prior art date
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Cell Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Oncology (AREA)
- Reproductive Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pulmonology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Biomedical Technology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1515094.9A GB201515094D0 (en) | 2015-08-25 | 2015-08-25 | Sialyl-di-lewis a as expressed on glycoproteins but not glycolipids as a functional cancer target and antibodies thereto |
| GB1515094.9 | 2015-08-25 | ||
| PCT/GB2016/052647 WO2017033020A1 (en) | 2015-08-25 | 2016-08-25 | Sialyl-di-lewis a as expressed on glycoproteins but not glycolipids as a functional cancer target and antibodies thereto |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112018003779A2 true BR112018003779A2 (pt) | 2018-09-25 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112018003779-6A BR112018003779A2 (pt) | 2015-08-25 | 2016-08-25 | sialil-di-lewis a conforme expresso em glicoproteínas, mas não glicolipídios, como um alvo de câncer funcional e anticorpos para o mesmo |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US10835618B2 (enExample) |
| EP (1) | EP3341412B1 (enExample) |
| JP (1) | JP6928602B2 (enExample) |
| KR (1) | KR102713512B1 (enExample) |
| CN (1) | CN108137695B (enExample) |
| BR (1) | BR112018003779A2 (enExample) |
| CA (1) | CA2996436A1 (enExample) |
| DK (1) | DK3341412T3 (enExample) |
| ES (1) | ES2788159T3 (enExample) |
| GB (1) | GB201515094D0 (enExample) |
| PT (1) | PT3341412T (enExample) |
| WO (1) | WO2017033020A1 (enExample) |
| ZA (1) | ZA201801994B (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT3041507T (lt) * | 2013-08-26 | 2021-08-25 | Biontech Research And Development, Inc. | Nukleorūgštys, koduojančios antikūnus prieš sialil-lewis a |
| JP7672340B2 (ja) * | 2018-10-19 | 2025-05-07 | メモリアル スローン ケタリング キャンサー センター | シアリルルイスaを標的とするキメラ抗原受容体およびその使用 |
| GB201910899D0 (en) * | 2019-07-31 | 2019-09-11 | Scancell Ltd | Binding members |
| GB201910900D0 (en) | 2019-07-31 | 2019-09-11 | Scancell Ltd | Modified fc-regions to enhance functional affinity of antibodies and antigen binding fragments thereof |
| WO2023133452A1 (en) * | 2022-01-06 | 2023-07-13 | PTM Therapeutics, Inc. | Methods of treating solid tumors and compositions thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT413486B (de) * | 2002-07-03 | 2006-03-15 | Igeneon Krebs Immuntherapie | Verwendung eines antikörpers gerichtet gegen lewis-antigene |
| LT3041507T (lt) | 2013-08-26 | 2021-08-25 | Biontech Research And Development, Inc. | Nukleorūgštys, koduojančios antikūnus prieš sialil-lewis a |
| GB201319374D0 (en) | 2013-11-01 | 2013-12-18 | Univ Nottingham | Glycans as functional cancer targets abd antibodies thereto |
-
2015
- 2015-08-25 GB GBGB1515094.9A patent/GB201515094D0/en not_active Ceased
-
2016
- 2016-08-25 KR KR1020187008554A patent/KR102713512B1/ko active Active
- 2016-08-25 CN CN201680056234.5A patent/CN108137695B/zh active Active
- 2016-08-25 JP JP2018510883A patent/JP6928602B2/ja active Active
- 2016-08-25 BR BR112018003779-6A patent/BR112018003779A2/pt active Search and Examination
- 2016-08-25 EP EP16760541.9A patent/EP3341412B1/en active Active
- 2016-08-25 PT PT167605419T patent/PT3341412T/pt unknown
- 2016-08-25 CA CA2996436A patent/CA2996436A1/en active Pending
- 2016-08-25 WO PCT/GB2016/052647 patent/WO2017033020A1/en not_active Ceased
- 2016-08-25 ES ES16760541T patent/ES2788159T3/es active Active
- 2016-08-25 US US15/754,882 patent/US10835618B2/en active Active
- 2016-08-25 DK DK16760541.9T patent/DK3341412T3/da active
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2018
- 2018-03-26 ZA ZA2018/01994A patent/ZA201801994B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2996436A1 (en) | 2017-03-02 |
| PT3341412T (pt) | 2020-05-21 |
| EP3341412A1 (en) | 2018-07-04 |
| DK3341412T3 (da) | 2020-05-18 |
| CN108137695A (zh) | 2018-06-08 |
| KR102713512B1 (ko) | 2024-10-04 |
| JP6928602B2 (ja) | 2021-09-01 |
| WO2017033020A1 (en) | 2017-03-02 |
| ZA201801994B (en) | 2019-01-30 |
| US20180236095A1 (en) | 2018-08-23 |
| EP3341412B1 (en) | 2020-03-25 |
| KR20180100541A (ko) | 2018-09-11 |
| US10835618B2 (en) | 2020-11-17 |
| CN108137695B (zh) | 2022-03-29 |
| ES2788159T3 (es) | 2020-10-20 |
| GB201515094D0 (en) | 2015-10-07 |
| JP2018529328A (ja) | 2018-10-11 |
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| Date | Code | Title | Description |
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| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
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| B25A | Requested transfer of rights approved |
Owner name: SCANCELL LIMITED (GB) |
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| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] |