BR112018001424A2 - compostos, composição farmacêutica e métodos para o tratamento de uma doença neoplásica, para o tratamento de um distúrbio inflamatório ou distúrbio autoimune, para o tratamento de uma doença neurodegenerativa e para o tratamento de um distúrbio metabólico - Google Patents

compostos, composição farmacêutica e métodos para o tratamento de uma doença neoplásica, para o tratamento de um distúrbio inflamatório ou distúrbio autoimune, para o tratamento de uma doença neurodegenerativa e para o tratamento de um distúrbio metabólico

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Publication number
BR112018001424A2
BR112018001424A2 BR112018001424-9A BR112018001424A BR112018001424A2 BR 112018001424 A2 BR112018001424 A2 BR 112018001424A2 BR 112018001424 A BR112018001424 A BR 112018001424A BR 112018001424 A2 BR112018001424 A2 BR 112018001424A2
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treatment
compounds
inflammatory
methods
pharmaceutical composition
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BR112018001424-9A
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English (en)
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BR112018001424B1 (pt
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Yen Yun
Liou Jing-Ping
Pan Shiow-Lin
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Taipei Medical University
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Publication of BR112018001424B1 publication Critical patent/BR112018001424B1/pt

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    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
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    • A61K31/12—Ketones
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • A—HUMAN NECESSITIES
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • C07C225/26—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones the carbon skeleton containing carbon atoms of quinone rings having amino groups bound to carbon atoms of quinone rings or of condensed ring systems containing quinone rings
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    • C07C237/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms not being part of nitro or nitroso groups
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    • C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Abstract

a presente invenção se refere aos novos compostos com baixa citotoxicidade para o bloqueio do sistema de proteassoma de ubiquitinação em doenças. consequentemente, estes compostos podem ser utilizados no tratamento de distúrbios de tratamento incluindo, mas não limitados aos cânceres, doenças neurodegenerativas, doenças inflamatórias e distúrbios autoimunes e distúrbios metabólicos.
BR112018001424-9A 2015-07-30 2016-07-30 Compostos, composição farmacêutica e usos de um composto BR112018001424B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562199207P 2015-07-30 2015-07-30
US62/199,207 2015-07-30
PCT/US2016/044932 WO2017020030A1 (en) 2015-07-30 2016-07-30 Compounds and pharmaceutical composition associated with ubiquitination-proteasome system

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BR112018001424A2 true BR112018001424A2 (pt) 2018-09-11
BR112018001424B1 BR112018001424B1 (pt) 2024-02-06

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EP (1) EP3328368B1 (pt)
JP (1) JP7017787B2 (pt)
CN (1) CN108366979B (pt)
AU (1) AU2016298962B2 (pt)
BR (1) BR112018001424B1 (pt)
CA (1) CA2993809C (pt)
DK (1) DK3328368T3 (pt)
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TWI684581B (zh) 2016-08-02 2020-02-11 臺北醫學大學 與泛素化-蛋白酶體系統有關之化合物及醫藥組合物

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