BR112017026392A2 - - Google Patents
Info
- Publication number
- BR112017026392A2 BR112017026392A2 BR112017026392A BR112017026392A BR112017026392A2 BR 112017026392 A2 BR112017026392 A2 BR 112017026392A2 BR 112017026392 A BR112017026392 A BR 112017026392A BR 112017026392 A BR112017026392 A BR 112017026392A BR 112017026392 A2 BR112017026392 A2 BR 112017026392A2
- Authority
- BR
- Brazil
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KP10-2015-0081021 | 2015-06-09 | ||
KR20150081021 | 2015-06-09 | ||
PCT/KR2016/005911 WO2016200101A2 (ko) | 2015-06-09 | 2016-06-03 | 트리사이클릭 유도체 화합물, 이의 제조방법 및 이를 포함하는 약학적 조성물 |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112017026392A2 true BR112017026392A2 (US20090163788A1-20090625-C00002.png) | 2018-08-21 |
BR112017026392B1 BR112017026392B1 (pt) | 2023-12-26 |
Family
ID=57503424
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112017026392-0A BR112017026392B1 (pt) | 2015-06-09 | 2016-06-03 | Composto derivado tricíclico, método para sua preparação e seu uso |
Country Status (21)
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ738187A (en) * | 2015-06-09 | 2019-03-29 | Je Il Pharmaceutical Co Ltd | Tricyclic derivative compound, method for preparing same, and pharmaceutical composition comprising same |
TN2017000498A1 (en) | 2015-06-09 | 2019-04-12 | Bayer Pharma AG | Positive allosteric modulators of muscarinic m2 receptor |
KR101775356B1 (ko) | 2015-07-06 | 2017-09-06 | 재단법인 아산사회복지재단 | Parp 및 탄키라제 동시 저해제에 대한 감수성 결정 방법 |
JP2019524722A (ja) | 2016-07-11 | 2019-09-05 | バイエル・ファルマ・アクティエンゲゼルシャフト | 7−置換1−ピリジル−ナフチリジン−3−カルボン酸アミドおよびその使用 |
JOP20190045A1 (ar) | 2016-09-14 | 2019-03-14 | Bayer Ag | مركبات أميد حمض 1- أريل-نفثيريدين-3-كربوكسيليك مستبدلة في الموضع 7 واستخدامها. |
CN108727377A (zh) * | 2017-04-14 | 2018-11-02 | 四川大学 | 3-氰基吡唑并[1,5-a]嘧啶衍生物及其制备方法和用途 |
CN111566105A (zh) | 2018-01-08 | 2020-08-21 | 豪夫迈·罗氏有限公司 | 作为MAGL抑制剂的八氢吡啶并[1,2-α]吡嗪类化合物 |
US20220110936A1 (en) * | 2019-02-02 | 2022-04-14 | Shanghai Institute Of Organic Chemistry, Chinese Academy Of Sciences | Pharmaceutical composition for treatment of neurodegenerative diseases or diseases caused by abnormality of rna binding protein and applications thereof |
WO2020207941A1 (en) * | 2019-04-09 | 2020-10-15 | F. Hoffmann-La Roche Ag | Heterocyclic compounds as inhibitors of monoacylglycerol lipase (magl) |
JOP20220008A1 (ar) * | 2019-07-19 | 2023-01-30 | Astrazeneca Ab | مثبطات parp1 |
AU2019459018A1 (en) * | 2019-07-29 | 2022-02-17 | Jeil Pharmaceutical Co.,Ltd | Method for treating stroke by using tricyclic derivative |
CN114555619A (zh) * | 2019-08-14 | 2022-05-27 | 麦德龙国际生物科技有限责任公司 | 用于烟酰胺腺嘌呤二核苷酸的差分调节的化合物和组合物 |
US11795158B2 (en) | 2020-06-25 | 2023-10-24 | Astrazeneca Ab | Chemical compounds |
GB202012969D0 (en) * | 2020-08-19 | 2020-09-30 | Univ Of Oxford | Inhibitor compounds |
CA3190277A1 (en) | 2020-09-03 | 2022-03-10 | Joerg Benz | Heterocyclic compounds |
US11591331B2 (en) | 2021-04-19 | 2023-02-28 | Xinthera, Inc. | PARP1 inhibitors and uses thereof |
AU2022261011A1 (en) * | 2021-04-22 | 2023-11-16 | Wigen Biomedicine Technology (shanghai) Co., Ltd. | Parp inhibitor containing piperazine structure, preparation method therefor and pharmaceutical use thereof |
WO2022222995A1 (zh) * | 2021-04-23 | 2022-10-27 | 南京明德新药研发有限公司 | 吡啶酰胺类化合物 |
WO2022222966A1 (zh) * | 2021-04-23 | 2022-10-27 | 成都百裕制药股份有限公司 | 一种选择性parp1抑制剂及其应用 |
BR112023023815A2 (pt) | 2021-05-18 | 2024-02-06 | Onconic Therapeutics Inc | Agente terapêutico de câncer resistente a inibidor de parp |
MX2023013624A (es) * | 2021-05-18 | 2023-11-30 | Onconic Therapeutics Inc | Forma cristalina del compuesto derivado triciclico, metodo para preparar la misma y composicion farmaceutica que comprende la misma. |
EP4382521A1 (en) * | 2021-08-05 | 2024-06-12 | Shujing Biopharma Co., Ltd | Regulator containing tricyclic derivative, preparation method therefor and application thereof |
KR20240053612A (ko) * | 2021-08-27 | 2024-04-24 | 임팩트 테라퓨틱스 (상하이), 인코포레이티드 | Parp 억제제로서 치환된 삼환 화합물 및 이의 용도 |
WO2023036285A1 (zh) * | 2021-09-09 | 2023-03-16 | 南京奥利墨斯医药科技有限公司 | 一种杂芳环类化合物及其应用 |
WO2023046034A1 (zh) * | 2021-09-22 | 2023-03-30 | 明慧医药(杭州)有限公司 | 一种含氮杂环化合物、其制备方法、其中间体及其应用 |
TW202322807A (zh) | 2021-10-01 | 2023-06-16 | 美商辛瑟拉股份有限公司 | 吖丁啶及吡咯啶parp1抑制劑及其用途 |
WO2023061406A1 (zh) * | 2021-10-12 | 2023-04-20 | 微境生物医药科技(上海)有限公司 | 含三并环结构的parp抑制剂、及其制备方法和医药用途 |
AU2022420969A1 (en) * | 2021-12-22 | 2024-06-13 | Synnovation Therapeutics, Inc. | Parp1 inhibitors |
CN116425744A (zh) * | 2022-01-13 | 2023-07-14 | 优领医药科技(香港)有限公司 | 含哌嗪并环类衍生物、其药学上可接受的盐及其制备方法和应用 |
US11939329B2 (en) | 2022-01-21 | 2024-03-26 | Xinthera, Inc. | PARP1 inhibitors and uses thereof |
WO2023169226A1 (en) * | 2022-03-11 | 2023-09-14 | Impact Therapeutics (Shanghai), Inc | Substituted tricyclic compounds as parp inhibitors and the use thereof |
WO2023212219A1 (en) | 2022-04-28 | 2023-11-02 | Xinthera, Inc. | Tricyclic parp1 inhibitors and uses thereof |
WO2023217045A1 (zh) * | 2022-05-07 | 2023-11-16 | 南京明德新药研发有限公司 | 选择性抑制parp1的氟代喹喔啉酮衍生物 |
CN115232129B (zh) * | 2022-08-18 | 2023-12-01 | 上海闻耐医药科技有限公司 | 一种parp1选择性抑制剂及其制备方法和用途 |
WO2024041608A1 (zh) * | 2022-08-24 | 2024-02-29 | 四川海思科制药有限公司 | 一种杂芳基衍生物parp抑制剂的晶体形式及其用途 |
WO2024041605A1 (zh) * | 2022-08-24 | 2024-02-29 | 四川海思科制药有限公司 | 一种杂芳基衍生物parp抑制剂药学上可接受的盐及其用途 |
WO2024099416A1 (zh) * | 2022-11-10 | 2024-05-16 | 上海海和药物研究开发股份有限公司 | 一种稠合三环类parp1抑制剂、其制备方法及用途 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5391554A (en) | 1992-09-09 | 1995-02-21 | Warner-Lambert Company | Dihydro- and tetrahydronaphthyridines |
AUPS137402A0 (en) * | 2002-03-26 | 2002-05-09 | Fujisawa Pharmaceutical Co., Ltd. | Novel tricyclic compounds |
DE102004028973A1 (de) | 2004-06-16 | 2006-01-05 | Sanofi-Aventis Deutschland Gmbh | Substituierte Tetrahydro-2H-isochinolin-1-on-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament |
BRPI0719123A2 (pt) * | 2006-09-01 | 2013-12-17 | Cylene Pharmaceuticals Inc | Moduladores de serina-treonina proteína cinase e parp |
PL2215075T3 (pl) * | 2007-10-26 | 2014-04-30 | Janssen Pharmaceutica Nv | Pochodne chinolinonu jako inhibitory PARP |
KR101179753B1 (ko) * | 2007-11-06 | 2012-09-04 | 제일약품주식회사 | 신규한 트리시클릭 유도체 또는 이의 약학적으로허용가능한 염, 이의 제조방법 및 이를 포함하는 약학조성물 |
KR100968175B1 (ko) * | 2008-11-11 | 2010-07-07 | 제일약품주식회사 | 신규한 트리시클릭 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 포함하는 약학적 조성물 |
KR101827444B1 (ko) * | 2012-02-01 | 2018-02-08 | 제일약품주식회사 | 트리사이클로 유도체 화합물의 신규한 결정형 산부가염 또는 이의 수화물 및 이의 제조방법 |
NZ738187A (en) * | 2015-06-09 | 2019-03-29 | Je Il Pharmaceutical Co Ltd | Tricyclic derivative compound, method for preparing same, and pharmaceutical composition comprising same |
KR101775356B1 (ko) * | 2015-07-06 | 2017-09-06 | 재단법인 아산사회복지재단 | Parp 및 탄키라제 동시 저해제에 대한 감수성 결정 방법 |
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2016
- 2016-06-03 NZ NZ738187A patent/NZ738187A/en unknown
- 2016-06-03 AU AU2016276806A patent/AU2016276806B9/en active Active
- 2016-06-03 RU RU2017146130A patent/RU2715413C2/ru active
- 2016-06-03 PL PL16807741T patent/PL3312177T3/pl unknown
- 2016-06-03 JP JP2017564557A patent/JP2018521033A/ja not_active Ceased
- 2016-06-03 EP EP16807741.0A patent/EP3312177B1/en active Active
- 2016-06-03 WO PCT/KR2016/005911 patent/WO2016200101A2/ko active Application Filing
- 2016-06-03 CN CN201680040992.8A patent/CN107849040B/zh active Active
- 2016-06-03 ES ES16807741T patent/ES2870203T3/es active Active
- 2016-06-03 BR BR112017026392-0A patent/BR112017026392B1/pt active IP Right Grant
- 2016-06-03 US US15/579,692 patent/US10464919B2/en active Active
- 2016-06-03 DK DK16807741.0T patent/DK3312177T3/da active
- 2016-06-03 KR KR1020160069199A patent/KR101837047B1/ko active IP Right Grant
- 2016-06-03 CA CA2990277A patent/CA2990277C/en active Active
- 2016-06-03 MY MYPI2017704653A patent/MY194590A/en unknown
- 2016-06-03 PT PT168077410T patent/PT3312177T/pt unknown
- 2016-06-03 MX MX2017016013A patent/MX2017016013A/es active IP Right Grant
-
2017
- 2017-12-07 SA SA517390509A patent/SA517390509B1/ar unknown
- 2017-12-07 PH PH12017502228A patent/PH12017502228A1/en unknown
- 2017-12-07 CL CL2017003138A patent/CL2017003138A1/es unknown
- 2017-12-19 ZA ZA2017/08663A patent/ZA201708663B/en unknown
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2019
- 2019-05-09 JP JP2019088851A patent/JP6806969B2/ja active Active
Also Published As
Similar Documents
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
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B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B25A | Requested transfer of rights approved |
Owner name: ONCONIC THERAPEUTICS INC. (KR) |
|
B350 | Update of information on the portal [chapter 15.35 patent gazette] | ||
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 03/06/2016, OBSERVADAS AS CONDICOES LEGAIS |