BR112017013264A2 - ?sal de cálcio de um polímero de aglutinação de potássio reticulado, polímero de aglutinação de potássio reticulado, composição farmacêutica, e, método para remover potássio do trato gastrointestinal de um paciente?. - Google Patents
?sal de cálcio de um polímero de aglutinação de potássio reticulado, polímero de aglutinação de potássio reticulado, composição farmacêutica, e, método para remover potássio do trato gastrointestinal de um paciente?.Info
- Publication number
- BR112017013264A2 BR112017013264A2 BR112017013264-8A BR112017013264A BR112017013264A2 BR 112017013264 A2 BR112017013264 A2 BR 112017013264A2 BR 112017013264 A BR112017013264 A BR 112017013264A BR 112017013264 A2 BR112017013264 A2 BR 112017013264A2
- Authority
- BR
- Brazil
- Prior art keywords
- potassium
- agglutination
- polymer
- crosslinked
- patient
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F8/00—Chemical modification by after-treatment
- C08F8/34—Introducing sulfur atoms or sulfur-containing groups
- C08F8/36—Sulfonation; Sulfation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/745—Polymers of hydrocarbons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/795—Polymers containing sulfur
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
- B01J39/08—Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
- B01J39/16—Organic material
- B01J39/18—Macromolecular compounds
- B01J39/20—Macromolecular compounds obtained by reactions only involving unsaturated carbon-to-carbon bonds
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F212/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an aromatic carbocyclic ring
- C08F212/02—Monomers containing only one unsaturated aliphatic radical
- C08F212/04—Monomers containing only one unsaturated aliphatic radical containing one ring
- C08F212/06—Hydrocarbons
- C08F212/08—Styrene
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F212/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an aromatic carbocyclic ring
- C08F212/02—Monomers containing only one unsaturated aliphatic radical
- C08F212/04—Monomers containing only one unsaturated aliphatic radical containing one ring
- C08F212/14—Monomers containing only one unsaturated aliphatic radical containing one ring substituted by heteroatoms or groups containing heteroatoms
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
- C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
- C08F220/10—Esters
- C08F220/22—Esters containing halogen
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F257/00—Macromolecular compounds obtained by polymerising monomers on to polymers of aromatic monomers as defined in group C08F12/00
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F8/00—Chemical modification by after-treatment
- C08F8/44—Preparation of metal salts or ammonium salts
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F2800/00—Copolymer characterised by the proportions of the comonomers expressed
- C08F2800/10—Copolymer characterised by the proportions of the comonomers expressed as molar percentages
Abstract
a presente invenção é direcionada a composições e métodos de remoção de potássio ou tratamento de hipercalemia por administração de composições farmacêuticas de polímeros de troca catiônica com baixa reticulação para excreção de potássio melhorada e para propriedades físicas benéficas para aumentar a adesão do paciente. em particular o pedido descreve o uso de poliestireno sulfonato de cálcio reticulado com uma reticulação menor que 5%.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462096447P | 2014-12-23 | 2014-12-23 | |
US62/096447 | 2014-12-23 | ||
PCT/US2015/067460 WO2016111855A1 (en) | 2014-12-23 | 2015-12-22 | Compositions and methods for treating hyperkalemia |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112017013264A2 true BR112017013264A2 (pt) | 2018-02-27 |
Family
ID=55229846
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112017013264-8A BR112017013264A2 (pt) | 2014-12-23 | 2015-12-22 | ?sal de cálcio de um polímero de aglutinação de potássio reticulado, polímero de aglutinação de potássio reticulado, composição farmacêutica, e, método para remover potássio do trato gastrointestinal de um paciente?. |
Country Status (17)
Country | Link |
---|---|
US (2) | US9655921B2 (pt) |
EP (1) | EP3236940B1 (pt) |
JP (3) | JP6821571B2 (pt) |
KR (1) | KR20170098259A (pt) |
CN (1) | CN107406548B (pt) |
AR (1) | AR103250A1 (pt) |
AU (1) | AU2015375390B2 (pt) |
BR (1) | BR112017013264A2 (pt) |
CA (1) | CA2971725A1 (pt) |
ES (1) | ES2800167T3 (pt) |
IL (1) | IL252603A0 (pt) |
MX (1) | MX2017007603A (pt) |
NZ (1) | NZ732542A (pt) |
RU (1) | RU2017126229A (pt) |
TW (1) | TW201628631A (pt) |
WO (1) | WO2016111855A1 (pt) |
ZA (1) | ZA201703771B (pt) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9549947B2 (en) | 2014-12-23 | 2017-01-24 | Ardelyx, Inc. | Pharmaceutical compositions for treating hyperkalemia |
EP3236940B1 (en) * | 2014-12-23 | 2020-02-05 | Ardelyx, Inc. | Compositions and methods for treating hyperkalemia |
WO2019060051A1 (en) | 2017-08-04 | 2019-03-28 | Ardelyx, Inc. | GLYCYRRHETINIC ACID DERIVATIVES FOR THE TREATMENT OF HYPERKALIEMIA |
WO2020163642A1 (en) | 2019-02-07 | 2020-08-13 | Ardelyx, Inc. | Glycyrrhetinic acid derivatives for use in treating hyperkalemia |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3785864A (en) | 1970-07-23 | 1974-01-15 | Boehringer Mannheim Gmbh | Process for the chromatographic separation of multi-component mixtures containing glucose |
GB1561395A (en) * | 1976-02-26 | 1980-02-20 | Beecham Group Ltd | -lactam antibiotic |
CA1166413A (en) | 1980-10-30 | 1984-05-01 | Edward E. Timm | Process and apparatus for preparing uniform size polymer beads |
JPS57193414A (en) * | 1981-05-25 | 1982-11-27 | Sekisui Chem Co Ltd | Preparation of remedy for hypercalcemia |
WO1999020285A1 (fr) * | 1997-10-16 | 1999-04-29 | Sanwa Kagaku Kenkyusho Co., Ltd. | Preparations de gels contenant un polystyrenesulfonate |
JP3596742B2 (ja) * | 1998-07-31 | 2004-12-02 | 日研化学株式会社 | 陽イオン交換樹脂製剤 |
KR100440544B1 (ko) * | 1998-07-31 | 2004-07-15 | 니켄 가가쿠 가부시키가이샤 | 양이온 교환수지 제제 |
US6270755B1 (en) * | 1999-05-13 | 2001-08-07 | Geltex Pharmaceuticals, Inc. | Anionic polymers as toxin binders |
US8192758B2 (en) * | 2004-03-30 | 2012-06-05 | Relypsa, Inc. | Ion binding compositions |
WO2008039358A2 (en) * | 2006-09-30 | 2008-04-03 | Capricorn Pharma Inc. | Resin-complex granulation for water-soluble drugs and associated methods |
DE102007050971B4 (de) * | 2007-03-14 | 2014-12-31 | BLüCHER GMBH | Verfahren zur Herstellung von Hochleistungsadsorbentien auf der Basis von Aktivkohle mit hoher Meso- und Makroporosität, Hochleistungsadsorbentien und deren Verwendung |
WO2010022381A1 (en) | 2008-08-22 | 2010-02-25 | Relypsa, Inc. | Treating hyperkalemia with crosslinked cation exchange polymers of improved physical properties |
EP2957286B1 (en) * | 2008-08-22 | 2018-11-21 | Vifor (International) Ltd. | Compositions comprising crosslinked cation exchange polymers and use in treating hyperkalemia |
US20110028412A1 (en) | 2009-08-03 | 2011-02-03 | Cappellos, Inc. | Herbal enhanced analgesic formulations |
ES2364683B1 (es) * | 2009-12-29 | 2012-08-08 | Bioibérica S.A. | Disacáridos sulfatados para el tratamiento de enfermedades neurodegenerativas y/o neurovasculares. |
WO2012108947A1 (en) * | 2011-01-10 | 2012-08-16 | Sorbent Therapeutics, Inc. | Crosslinked cation-binding polymers for the use in the treatment of heart failure |
TWI605837B (zh) | 2011-01-27 | 2017-11-21 | Kowa Co Ltd | Pharmaceutical composition containing water-insoluble drug and pharmaceutical preparation |
ES2441468B1 (es) * | 2012-08-03 | 2014-11-13 | Laboratorios Rubió, S.A. | Composición farmacéutica sólida de resina de intercambio catiónico. |
ES2471340B1 (es) | 2012-12-21 | 2015-08-17 | Laboratorios Rubió, S.A. | Composición farmacéutica oral para fármacos de elevada posología |
EP3236940B1 (en) * | 2014-12-23 | 2020-02-05 | Ardelyx, Inc. | Compositions and methods for treating hyperkalemia |
-
2015
- 2015-12-22 EP EP15828619.5A patent/EP3236940B1/en active Active
- 2015-12-22 CN CN201580069983.7A patent/CN107406548B/zh active Active
- 2015-12-22 CA CA2971725A patent/CA2971725A1/en active Pending
- 2015-12-22 US US14/912,682 patent/US9655921B2/en active Active
- 2015-12-22 BR BR112017013264-8A patent/BR112017013264A2/pt not_active Application Discontinuation
- 2015-12-22 AR ARP150104260A patent/AR103250A1/es unknown
- 2015-12-22 AU AU2015375390A patent/AU2015375390B2/en active Active
- 2015-12-22 WO PCT/US2015/067460 patent/WO2016111855A1/en active Application Filing
- 2015-12-22 ES ES15828619T patent/ES2800167T3/es active Active
- 2015-12-22 JP JP2017533536A patent/JP6821571B2/ja active Active
- 2015-12-22 RU RU2017126229A patent/RU2017126229A/ru unknown
- 2015-12-22 KR KR1020177019904A patent/KR20170098259A/ko active IP Right Grant
- 2015-12-22 MX MX2017007603A patent/MX2017007603A/es active IP Right Grant
- 2015-12-22 TW TW104143161A patent/TW201628631A/zh unknown
- 2015-12-22 NZ NZ732542A patent/NZ732542A/en unknown
-
2017
- 2017-04-14 US US15/487,967 patent/US20180064751A1/en not_active Abandoned
- 2017-06-01 ZA ZA201703771A patent/ZA201703771B/en unknown
- 2017-06-01 IL IL252603A patent/IL252603A0/en unknown
-
2020
- 2020-07-17 JP JP2020122933A patent/JP7254748B2/ja active Active
-
2022
- 2022-12-22 JP JP2022205560A patent/JP2023027355A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
KR20170098259A (ko) | 2017-08-29 |
JP6821571B2 (ja) | 2021-01-27 |
AR103250A1 (es) | 2017-04-26 |
TW201628631A (zh) | 2016-08-16 |
JP2018505262A (ja) | 2018-02-22 |
JP2023027355A (ja) | 2023-03-01 |
NZ732542A (en) | 2023-02-24 |
US20160346318A1 (en) | 2016-12-01 |
RU2017126229A (ru) | 2019-01-28 |
WO2016111855A1 (en) | 2016-07-14 |
JP2020172662A (ja) | 2020-10-22 |
ZA201703771B (en) | 2020-11-25 |
ES2800167T3 (es) | 2020-12-28 |
EP3236940A1 (en) | 2017-11-01 |
JP7254748B2 (ja) | 2023-04-10 |
MX2017007603A (es) | 2017-10-19 |
EP3236940B1 (en) | 2020-02-05 |
CN107406548A (zh) | 2017-11-28 |
US20180064751A1 (en) | 2018-03-08 |
AU2015375390B2 (en) | 2021-06-24 |
AU2015375390A1 (en) | 2017-06-29 |
IL252603A0 (en) | 2017-07-31 |
CA2971725A1 (en) | 2016-07-14 |
CN107406548B (zh) | 2021-03-02 |
US9655921B2 (en) | 2017-05-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PH12018501226A1 (en) | Methods for treating huntingtons disease | |
BR112018000906A2 (pt) | ?composto, medicamento, métodos de inibição da histona desacetilase em um mamífero, e para a profilaxia ou o tratamento de doenças, e, uso de um composto? | |
BR112017018368A2 (pt) | composições contendo rna para o tratamento de doenças tumorais | |
BR112015009162A2 (pt) | Gel de ácido hialurônico reticulado, processo para preparar um gel de ácido hialurônico reticulado, composições dermatológicas, kit e uso de um gel de ácido hialurônico reticulado | |
BR112016027041A8 (pt) | combinações farmacêuticas para tratamento do câncer | |
BR112017010893A2 (pt) | análogos de ácidos biliares como agonistas de fxr/tgr5 e métodos de uso dos mesmos | |
DOP2016000109A (es) | Formas sólidas de ácido {[5-(3-clorofenil) -3-hidroxipiridin-2-carbonil] amino} acético, composiciones, y usos de las mismas. | |
BR112017013264A2 (pt) | ?sal de cálcio de um polímero de aglutinação de potássio reticulado, polímero de aglutinação de potássio reticulado, composição farmacêutica, e, método para remover potássio do trato gastrointestinal de um paciente?. | |
BR112014021104A2 (pt) | métodos e composições para o tratamento da doença de huntington | |
CL2013002573A1 (es) | Composición que comprende un extracto o preparación de heces humanas; metodo para reemplazar o complementar o modificar la microbiota de colon de un sujeto; uso de dicha composicion para tratar enfermedad o afección patológica o iatrogénica del colon. | |
BR112018013011A2 (pt) | composições de alimento para animais de estimação | |
BR112018005905A2 (pt) | ?composto, composição farmacêutica, métodos para evitar ou tratar uma doença ou condição, lesões de órgão, hepatotoxicidade e fígado gorduroso, e, uso de um composto? | |
BR112016027043A8 (pt) | combinação, composição farmacêutica compreendendo glucocorticoide e edo-s101, kit e uso no tratamento de câncer | |
CL2017000382A1 (es) | Compuestos bicíclicos sustituidos | |
BR112016026545A8 (pt) | eribulina ou um sal farmaceuticamente aceitável do mesmo, seus usos e kit para utilização no tratamento de câncer da mama | |
BR112016020260A8 (pt) | uso de um composto na fabricação de um medicamento para tratar uma doença colestática intra-hepática | |
BR112017007138A2 (pt) | composto, medicamento, métodos para reduzir proteína 4 de ligação ao retinol e para a profilaxia ou o tratamento de degeneração macular e/ou uma doença, e, uso de um composto. | |
BR112017010832A2 (pt) | composições de aminoácido para o tratamento de sintomas de doença | |
BR112018014467A2 (pt) | tecnologia de sinergismo fármaco-anticorpo para o tratamento de doenças | |
EA201692111A1 (ru) | Фармацевтические композиции, содержащие данириксин, для лечения инфекционных заболеваний | |
AR094851A1 (es) | COMPUESTOS BICíCLICOS COMO AGONISTAS DE S1P₁ | |
FI20115165A0 (fi) | Terapeuttisia ja diagnostisia menetelmiä | |
BR112015016033A2 (pt) | composições e métodos para tratamento de infecções por bactérias | |
EA201992382A2 (ru) | Пероральная таблетированная фармацевтическая композиция двойного применения на основе сульфатных солей и способы ее применения | |
CY1122457T1 (el) | Μη πτητικες οφθαλμικες συνθεσεις, ειδικες για τη θεραπεια της ξηροφθαλμιας |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |