JPS57193414A - Preparation of remedy for hypercalcemia - Google Patents
Preparation of remedy for hypercalcemiaInfo
- Publication number
- JPS57193414A JPS57193414A JP7993481A JP7993481A JPS57193414A JP S57193414 A JPS57193414 A JP S57193414A JP 7993481 A JP7993481 A JP 7993481A JP 7993481 A JP7993481 A JP 7993481A JP S57193414 A JPS57193414 A JP S57193414A
- Authority
- JP
- Japan
- Prior art keywords
- give
- remedy
- divinylbenzene
- subjected
- ion exchange
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PURPOSE: To obtain the titled remedy, by copolymerizing styrene with divinylbenzene to give an approximately spherical copolymer having specific particle diameters, sulfonating it, subjecting it to ion exchange with a specific compound.
CONSTITUTION: Styrene and divinylbenzene are subjected to aqueous suspension polymerization in the presence of ≤5wt% based on total amount of monomers of vinylbenzenesulfonic acid or its salt, to give an approximately spherical copolymer having particle diameters of 10W100micron. In polymerization, the monomers blended with a catalyst (e.g., benzoyl peroxide, etc.) are dispersed into a medium dissolving a dispersant, heated at 60W80°C in a nitrogen flow, and reacted. The polymer is sulfonated in conc, sulfuric acid at 95W100°C, and subjected to ion exchange with a sodium compound or a calcium compound, to give a remedy for hypercalcemia.
EFFECT: Oral medication of the agent is carried out easily by a small amount of water and it is excreted quickly to the outside of the body.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP7993481A JPS57193414A (en) | 1981-05-25 | 1981-05-25 | Preparation of remedy for hypercalcemia |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP7993481A JPS57193414A (en) | 1981-05-25 | 1981-05-25 | Preparation of remedy for hypercalcemia |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS57193414A true JPS57193414A (en) | 1982-11-27 |
JPS649294B2 JPS649294B2 (en) | 1989-02-16 |
Family
ID=13704141
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP7993481A Granted JPS57193414A (en) | 1981-05-25 | 1981-05-25 | Preparation of remedy for hypercalcemia |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57193414A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999020247A1 (en) * | 1997-10-16 | 1999-04-29 | Sanwa Kagaku Kenkyusho Co., Ltd. | Gel preparation containing polystyrene-sulfonates |
WO2016111855A1 (en) * | 2014-12-23 | 2016-07-14 | Ardelyx, Inc. | Compositions and methods for treating hyperkalemia |
US9433640B2 (en) | 2014-12-23 | 2016-09-06 | Ardelyx, Inc. | Compositions and methods for treating hyperkalemia |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5343839A (en) * | 1976-10-01 | 1978-04-20 | Fuji Electrochemical Co Ltd | Method of manufacturing separator film for layerrbuilt dry battery |
-
1981
- 1981-05-25 JP JP7993481A patent/JPS57193414A/en active Granted
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5343839A (en) * | 1976-10-01 | 1978-04-20 | Fuji Electrochemical Co Ltd | Method of manufacturing separator film for layerrbuilt dry battery |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999020247A1 (en) * | 1997-10-16 | 1999-04-29 | Sanwa Kagaku Kenkyusho Co., Ltd. | Gel preparation containing polystyrene-sulfonates |
WO2016111855A1 (en) * | 2014-12-23 | 2016-07-14 | Ardelyx, Inc. | Compositions and methods for treating hyperkalemia |
US9433640B2 (en) | 2014-12-23 | 2016-09-06 | Ardelyx, Inc. | Compositions and methods for treating hyperkalemia |
US9545425B2 (en) | 2014-12-23 | 2017-01-17 | Ardelyx, Inc. | Pharmaceutical compositions for treating hyperkalemia |
US9549947B2 (en) | 2014-12-23 | 2017-01-24 | Ardelyx, Inc. | Pharmaceutical compositions for treating hyperkalemia |
CN107406548A (en) * | 2014-12-23 | 2017-11-28 | 阿德利克斯公司 | For treating the composition and method of potassemia |
US9867848B2 (en) | 2014-12-23 | 2018-01-16 | Ardelyx, Inc. | Compositions and methods for treating hyperkalemia |
US9919006B2 (en) | 2014-12-23 | 2018-03-20 | Ardelyx, Inc. | Compositions and methods for treating hyperkalemia |
Also Published As
Publication number | Publication date |
---|---|
JPS649294B2 (en) | 1989-02-16 |
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