BR112017009152A2 - métodos de produção de proteínas de duas cadeias em bactérias - Google Patents

métodos de produção de proteínas de duas cadeias em bactérias

Info

Publication number
BR112017009152A2
BR112017009152A2 BR112017009152A BR112017009152A BR112017009152A2 BR 112017009152 A2 BR112017009152 A2 BR 112017009152A2 BR 112017009152 A BR112017009152 A BR 112017009152A BR 112017009152 A BR112017009152 A BR 112017009152A BR 112017009152 A2 BR112017009152 A2 BR 112017009152A2
Authority
BR
Brazil
Prior art keywords
bacteria
production methods
protein production
chain protein
methods
Prior art date
Application number
BR112017009152A
Other languages
English (en)
Portuguese (pt)
Inventor
Reilly Dorothea
GIULIANOTTI James
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of BR112017009152A2 publication Critical patent/BR112017009152A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
BR112017009152A 2014-11-05 2015-11-05 métodos de produção de proteínas de duas cadeias em bactérias BR112017009152A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462075792P 2014-11-05 2014-11-05
US201562207882P 2015-08-20 2015-08-20
PCT/US2015/059339 WO2016073791A1 (en) 2014-11-05 2015-11-05 Methods of producing two chain proteins in bacteria

Publications (1)

Publication Number Publication Date
BR112017009152A2 true BR112017009152A2 (pt) 2018-03-06

Family

ID=54754738

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017009152A BR112017009152A2 (pt) 2014-11-05 2015-11-05 métodos de produção de proteínas de duas cadeias em bactérias

Country Status (12)

Country Link
US (2) US10112994B2 (https=)
EP (1) EP3215526A1 (https=)
JP (3) JP6875276B2 (https=)
KR (1) KR102709593B1 (https=)
CN (1) CN108064308B (https=)
AU (1) AU2015342961B2 (https=)
BR (1) BR112017009152A2 (https=)
CA (1) CA2966558C (https=)
IL (1) IL252027B (https=)
MX (1) MX384534B (https=)
RU (1) RU2705274C2 (https=)
WO (1) WO2016073791A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
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US10066002B2 (en) 2014-11-05 2018-09-04 Genentech, Inc. Methods of producing two chain proteins in bacteria
WO2016073791A1 (en) 2014-11-05 2016-05-12 Genentech, Inc. Methods of producing two chain proteins in bacteria
EP3877407B1 (en) * 2018-11-05 2026-03-11 F. Hoffmann-La Roche AG Methods of producing two chain proteins in prokaryotic host cells
KR102794884B1 (ko) * 2019-01-23 2025-04-15 제넨테크, 인크. 진핵 숙주 세포에서 다합체 단백질을 생산하는 방법
GB201919061D0 (en) 2019-12-20 2020-02-05 Ucb Biopharma Sprl Multi-specific antibody
EP4540284A2 (en) 2022-06-17 2025-04-23 Apogee Therapeutics, Inc. Antibodies that bind interleukin 13 and methods of use

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Also Published As

Publication number Publication date
MX2017005930A (es) 2017-06-30
US11299539B2 (en) 2022-04-12
JP2018500008A (ja) 2018-01-11
RU2017119403A (ru) 2018-12-05
CN108064308B (zh) 2023-06-09
US20190112368A1 (en) 2019-04-18
JP2023088935A (ja) 2023-06-27
AU2015342961A1 (en) 2017-06-15
IL252027B (en) 2021-10-31
CN108064308A (zh) 2018-05-22
KR20170075793A (ko) 2017-07-03
US10112994B2 (en) 2018-10-30
CA2966558C (en) 2024-03-12
CA2966558A1 (en) 2016-05-12
AU2015342961B2 (en) 2021-08-12
IL252027A0 (en) 2017-06-29
EP3215526A1 (en) 2017-09-13
MX384534B (es) 2025-03-14
US20160159898A1 (en) 2016-06-09
KR102709593B1 (ko) 2024-09-26
RU2705274C2 (ru) 2019-11-06
JP2021119777A (ja) 2021-08-19
JP6875276B2 (ja) 2021-05-19
RU2017119403A3 (https=) 2019-03-27
WO2016073791A1 (en) 2016-05-12
HK1255201A1 (zh) 2019-08-09

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