BR112017002724A2 - diagnóstico e terapia de câncer - Google Patents

diagnóstico e terapia de câncer

Info

Publication number
BR112017002724A2
BR112017002724A2 BR112017002724A BR112017002724A BR112017002724A2 BR 112017002724 A2 BR112017002724 A2 BR 112017002724A2 BR 112017002724 A BR112017002724 A BR 112017002724A BR 112017002724 A BR112017002724 A BR 112017002724A BR 112017002724 A2 BR112017002724 A2 BR 112017002724A2
Authority
BR
Brazil
Prior art keywords
renin
receptor
therapy
cancer diagnosis
cancer
Prior art date
Application number
BR112017002724A
Other languages
English (en)
Inventor
Frank Davis Paul
Francesca BAILLIE Ranui
Thong TAN Swee
Itinteang Tinte
Original Assignee
Gillies Mcindoe Res Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gillies Mcindoe Res Institute filed Critical Gillies Mcindoe Res Institute
Publication of BR112017002724A2 publication Critical patent/BR112017002724A2/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57496—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving intracellular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)

Abstract

a presente invenção fornece um novo método para diagnóstico de câncer e terapia de câncer fornecendo-se composições e métodos para a identificação e alvejamento específico das populações de célula tronco cancerosa presentes em um tumor para erradicar, ou diminuir ou prevenir o crescimento e disseminação de tumor (5), incluindo o potencial para a metástase de tumor, pela modulação do sistema de renina-angiotensina incluindo, mas não limitado a, receptor de renina, receptor de angiotensina ii (2) e uma forma secretada do receptor de renina.
BR112017002724A 2014-08-12 2015-08-12 diagnóstico e terapia de câncer BR112017002724A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462036583P 2014-08-12 2014-08-12
PCT/NZ2015/050108 WO2016024870A1 (en) 2014-08-12 2015-08-12 Cancer diagnosis and therapy

Publications (1)

Publication Number Publication Date
BR112017002724A2 true BR112017002724A2 (pt) 2018-01-16

Family

ID=55304402

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017002724A BR112017002724A2 (pt) 2014-08-12 2015-08-12 diagnóstico e terapia de câncer

Country Status (12)

Country Link
US (2) US10281472B2 (pt)
EP (1) EP3180000A4 (pt)
JP (1) JP6899771B2 (pt)
KR (1) KR20170040804A (pt)
CN (1) CN106999471A (pt)
AU (1) AU2015302419B2 (pt)
BR (1) BR112017002724A2 (pt)
CA (1) CA2957930A1 (pt)
CL (1) CL2017000373A1 (pt)
MX (1) MX2017001954A (pt)
SG (2) SG10201901157QA (pt)
WO (1) WO2016024870A1 (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20190048416A1 (en) * 2015-11-30 2019-02-14 Gillies Mcindoe Research Institute Treatment of fibrotic conditions
US20170360829A1 (en) * 2016-01-27 2017-12-21 Gillies Mcindoe Research Institute Treatment of vascular anomalies
WO2017207656A1 (en) * 2016-05-31 2017-12-07 Inserm (Institut National De La Sante Et De La Recherche Medicale) Atp6ap2 inhibition for treating or preventing a tumoural and/or proliferative disorder of the central nervous system
CN110494142A (zh) * 2017-01-31 2019-11-22 吉利斯麦金德研究院 癌症治疗
WO2019079222A1 (en) 2017-10-16 2019-04-25 Board Of Regents Of The University Of Texas System COMPOSITIONS FOR INHIBITING 3 'REPLACEMENT EXONUCLEASE 2 AND SCREENING METHODS FOR SUCH COMPOSITIONS
JP2021500391A (ja) * 2017-10-24 2021-01-07 マジェンタ セラピューティクス インコーポレイテッドＭａｇｅｎｔａ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． Ｃｄ１１７＋細胞を減少させるための組成物及び方法
WO2020027665A1 (en) * 2018-07-30 2020-02-06 Gillies Mcindoe Research Institute Novel pharmaceutical compositions for cancer therapy
WO2020028007A1 (en) * 2018-07-31 2020-02-06 Colorado State University Research Foundation Compositions, methods and uses for modulating the tumor microenvironment to enhance antitumor immunity
CN111304324B (zh) * 2020-02-21 2021-05-14 温州医科大学 Alpl基因作为肺腺癌及其转移的诊治靶标的应用
BR112022022585A2 (pt) * 2020-05-08 2022-12-13 23 Ikigai Pte Ltd Métodos para a identificação de uma condição médica em um indivíduo humano
CN113069443A (zh) * 2021-04-12 2021-07-06 四川大学 奈必洛尔在制备预防和/或治疗口腔白斑及口腔鳞状细胞癌的药物中的用途

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4121547A1 (de) 1991-06-28 1993-01-14 Daimler Benz Ag Mehrschichtisolierfolie
US6162432A (en) 1991-10-07 2000-12-19 Biogen, Inc. Method of prophylaxis or treatment of antigen presenting cell driven skin conditions using inhibitors of the CD2/LFA-3 interaction
US7361336B1 (en) 1997-09-18 2008-04-22 Ivan Bergstein Methods of cancer therapy targeted against a cancer stem line
US6004528A (en) 1997-09-18 1999-12-21 Bergstein; Ivan Methods of cancer diagnosis and therapy targeted against the cancer stemline
US6946475B1 (en) * 1999-04-07 2005-09-20 University Of Virginia Patent Foundation Anticancer calcium channel blockers
CA2895884C (en) 2000-03-06 2019-04-23 University Of Kentucky Research Foundation A compound that selectively binds to cd123 and use thereof to kill hematologic cancer progenitor cells
US6605589B1 (en) * 2000-03-31 2003-08-12 Parker Hughes Institute Cathepsin inhibitors in cancer treatment
AU2002322478A1 (en) 2001-03-02 2002-12-16 Medimmune, Inc. Methods of administering/dosing cd2 antagonists for the prevention and treatment of autoimmune disorders or inflammatory disorders
US6632832B1 (en) * 2002-09-10 2003-10-14 Dabur Research Foundation Anti-cancer activity of carvedilol and its isomers
CA2521826C (en) 2003-04-11 2013-08-06 Jennifer L. Reed Recombinant il-9 antibodies and uses thereof
JP5662319B2 (ja) * 2008-09-09 2015-01-28 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング アザ−ベンゾイミダゾロンキマーゼ阻害剤
EP2361988B1 (en) * 2008-10-27 2016-04-13 Sapporo Medical University Molecular marker for cancer stem cell
WO2012030234A1 (en) 2010-09-01 2012-03-08 Swee Thong Tan Methods and compositions for treating cancer
US20150125445A1 (en) * 2012-06-13 2015-05-07 University of Virginia Patent Foundation, d/b/a University of Virginia Licensing & Ventures Group Compositions and methods for treating cancer
WO2014205184A2 (en) * 2013-06-19 2014-12-24 University Of Miami Classification system, methods and kit for classifying. predicting and treating breast cancer

Also Published As

Publication number Publication date
US10281472B2 (en) 2019-05-07
EP3180000A1 (en) 2017-06-21
US20170234884A1 (en) 2017-08-17
JP6899771B2 (ja) 2021-07-14
MX2017001954A (es) 2017-08-14
KR20170040804A (ko) 2017-04-13
SG10201901157QA (en) 2019-03-28
AU2015302419B2 (en) 2021-04-01
AU2015302419A1 (en) 2017-03-09
US20200041521A1 (en) 2020-02-06
EP3180000A4 (en) 2018-03-07
CN106999471A (zh) 2017-08-01
WO2016024870A1 (en) 2016-02-18
JP2017532368A (ja) 2017-11-02
SG11201701035SA (en) 2017-03-30
CL2017000373A1 (es) 2018-01-12
CA2957930A1 (en) 2016-02-18

Similar Documents

Publication Publication Date Title
BR112017002724A2 (pt) diagnóstico e terapia de câncer
CL2018001897A1 (es) Composiciones para modular la expresión de sod-1 (divisional solicitud 201602509)
MX2021006581A (es) Bacterias modificadas para tratar enfermedades asociadas con hiperamonemia.
PH12019502724A1 (en) Compositions for modulating c9orf72 expression
SG10201903823QA (en) Methods and compositions relating to microbial treatment and diagnosis of disorders
BR112017024384A2 (pt) bactérias modificadas para reduzir hiperfenilalaninemia
MX2020011749A (es) Composiciones y metodos para modular la expresion de pkk.
MX2017013562A (es) Reguladores de microbioma y usos relacionados de los mismos.
AR082340A1 (es) Metodos y composiciones para la terapia del cancer de higado
BR112015018625A2 (pt) composições e métodos
BR112015019995A2 (pt) Combinação terapêutica envolvendo anticorpos contra claudina 18.2 para tratamento de câncer
MX2016014306A (es) Marcadores para terapia con lipoproteinas de alta densidad (hdl).
MX361533B (es) Anticuerpos anti-cd22.
MX2017005861A (es) Metodos para el control transcripcional objetivo en regiones del super mejorador.
ECSP15011764A (es) Antiandrógenos para el tratamiento del cáncer de próstata resistente a la castración no metastásico
MX2021006626A (es) Marcadores geneticos para predecir la reactividad a terapia con agente que eleva la lipoproteina de alta densidad (hdl) o que imita la lipoproteina de alta densidad (hdl).
NZ703411A (en) Use of markers in the diagnosis and treatment of prostate cancer
BR112018012913A2 (pt) tratamento in situ de sementes em sulco
TW201613949A (en) Targeting microRNAs for metabolic disorders
MY184878A (en) Compositions and methods for treating neurodegenerative diseases
CR20150638A (es) Marcador para trastornos de la esfingomielinasa ácida y sus usos
MX371343B (es) Moduladores del receptor x hepatico (lxr).
WO2012143382A3 (en) Gpr177 as target and marker in tumors
MX2017006491A (es) Composiciones y métodos para la modulación de la actividad at2r.
UA78643U (ru) Способ лечения очаговой патологии печени метастатического генеза

Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B08F Application fees: application dismissed [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2595 DE 29-09-2020 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.