BR112017000690A2 - geração de um banco de células mesênquimas do estroma a partir das células mononucleares reunidas de múltiplos doadores de medula óssea - Google Patents
geração de um banco de células mesênquimas do estroma a partir das células mononucleares reunidas de múltiplos doadores de medula ósseaInfo
- Publication number
- BR112017000690A2 BR112017000690A2 BR112017000690A BR112017000690A BR112017000690A2 BR 112017000690 A2 BR112017000690 A2 BR 112017000690A2 BR 112017000690 A BR112017000690 A BR 112017000690A BR 112017000690 A BR112017000690 A BR 112017000690A BR 112017000690 A2 BR112017000690 A2 BR 112017000690A2
- Authority
- BR
- Brazil
- Prior art keywords
- bone marrow
- msc
- donors
- mononuclear cells
- mesenchymal stromal
- Prior art date
Links
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
- C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Developmental Biology & Embryology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Diabetes (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Analytical Chemistry (AREA)
- Endocrinology (AREA)
- Molecular Biology (AREA)
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Abstract
a presente invenção refere-se a uma preparação melhorada de células mesênquimas do estroma (msc) e a um método para a sua produção. a invenção fornece uma nova estratégia para isolar a msc de células mononucleares da medula óssea (bm-mncs) através da reunião de bm-mncs de múltiplos doadores de medula óssea não relacionados (terceira parte). a preparação msc produzida de acordo com a metodologia da invenção é caracterizada por uma capacidade proliferativa estável e um potencial imunossupressor aumentado quando comparado com as preparações de msc de doadores individuais ou um conjunto de mscs individuais geradas a partir de múltiplos doadores. as mscs preparadas de acordo com a invenção são particularmente úteis para aplicações médicas tais como o tratamento de doença de enxerto versus hospedeiro (gvhd) em receptores com transplantes de células-tronco hematopoiéticas, pacientes com distúrbios autoimunes e como uma terapia baseada na célula na medicina regenerativa.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP14177312.7A EP2975118B1 (en) | 2014-07-16 | 2014-07-16 | Generation of a mesenchymal stromal cell bank from the pooled mononuclear cells of multiple bone marrow donors |
EP14177312.7 | 2014-07-16 | ||
PCT/EP2015/066083 WO2016008895A1 (en) | 2014-07-16 | 2015-07-14 | Generation of a mesenchymal stromal cell bank from the pooled mononuclear cells of multiple bone marrow donors |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112017000690A2 true BR112017000690A2 (pt) | 2017-11-14 |
BR112017000690B1 BR112017000690B1 (pt) | 2023-05-09 |
Family
ID=51224728
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112017000690-1A BR112017000690B1 (pt) | 2014-07-16 | 2015-07-14 | Método in vitro para a produção de preparação de células mesenquimais do estroma e composição celular |
Country Status (26)
Country | Link |
---|---|
US (3) | US10472608B2 (pt) |
EP (3) | EP2975118B1 (pt) |
JP (1) | JP6756701B2 (pt) |
KR (1) | KR102408357B1 (pt) |
CN (1) | CN106536719B (pt) |
AU (1) | AU2015289218B2 (pt) |
BR (1) | BR112017000690B1 (pt) |
CA (1) | CA2954505C (pt) |
CY (1) | CY1123343T1 (pt) |
DK (1) | DK3169772T3 (pt) |
EA (1) | EA037412B1 (pt) |
ES (1) | ES2817848T3 (pt) |
HR (1) | HRP20201487T1 (pt) |
HU (1) | HUE050579T2 (pt) |
IL (1) | IL249916B (pt) |
LT (1) | LT3169772T (pt) |
MX (1) | MX2017000704A (pt) |
NZ (1) | NZ728022A (pt) |
PL (1) | PL3169772T3 (pt) |
PT (1) | PT3169772T (pt) |
RS (1) | RS60863B1 (pt) |
SA (1) | SA517380722B1 (pt) |
SG (1) | SG11201700269WA (pt) |
SI (1) | SI3169772T1 (pt) |
UA (1) | UA122562C2 (pt) |
WO (1) | WO2016008895A1 (pt) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106492194A (zh) * | 2016-11-30 | 2017-03-15 | 广州赛莱拉干细胞科技股份有限公司 | 一种干细胞外泌体制剂及其制备方法和应用 |
CA3090217A1 (en) * | 2018-02-16 | 2019-08-22 | Nextcell Pharma Ab | Allogeneic composition |
RU2741769C2 (ru) * | 2018-12-21 | 2021-01-28 | Андрей Степанович БРЮХОВЕЦКИЙ | Биомедицинский клеточный продукт, способ его получения и применения |
US11697799B2 (en) | 2019-04-15 | 2023-07-11 | Ossium Health, Inc. | System and method for extraction and cryopreservation of bone marrow |
US20220305058A1 (en) | 2019-08-16 | 2022-09-29 | Johann Wolfgang Goethe-Universität Frankfurt am Main | Mesenchymal stromal cell bone graft material |
EP4013468A1 (en) | 2019-08-16 | 2022-06-22 | Johann-Wolfgang-Goethe-Universität Frankfurt am Main | Bone marrow derived cell bone graft material |
EP3909592A1 (en) | 2020-05-13 | 2021-11-17 | Johann Wolfgang Goethe-Universität Frankfurt am Main | Treatment of complications caused by infections of severe acute respiratory syndrome coronavirus |
EP4181675A4 (en) | 2020-07-18 | 2024-04-24 | Ossium Health, Inc. | PERMEATION OF WHOLE VERTEBRAL BODY WITH CRYOPROTECTIVE USING VACUUM-ASSISTED DIFFUSION |
AU2021360590A1 (en) | 2020-10-14 | 2023-06-15 | Ossium Health, Inc. | Systems and methods for extraction and cryopreservation of bone marrow |
CN116583594A (zh) * | 2020-10-14 | 2023-08-11 | 奥瑟姆健康公司 | 用于骨髓的提取和低温保藏的系统和方法 |
EP4262831A1 (en) | 2020-12-18 | 2023-10-25 | Ossium Health, Inc. | Methods of cell therapies |
WO2024038118A1 (en) * | 2022-08-16 | 2024-02-22 | Drk Blutspendedienst Baden-Württemberg-Hessen Ggmbh | Pooled mesenchymal stromal cell derived cells, cell- and cell-free preparations thereof |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5486359A (en) | 1990-11-16 | 1996-01-23 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells |
CN1576364A (zh) * | 2003-07-29 | 2005-02-09 | 赵春华 | 异基因骨髓间充质干细胞移植嵌合模型的建立、鉴定及应用 |
ES2897598T3 (es) * | 2009-11-27 | 2022-03-01 | Stempeutics Res Pvt Ltd | Métodos de preparación de células madre mesenquimales, composiciones y kit de las mismas |
EP2624845A4 (en) | 2010-10-08 | 2015-09-09 | Mesoblast Internat S Rl | REINFORCED MSC PREPARATIONS |
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2014
- 2014-07-16 EP EP14177312.7A patent/EP2975118B1/en active Active
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2015
- 2015-07-14 MX MX2017000704A patent/MX2017000704A/es unknown
- 2015-07-14 LT LTEP15736516.4T patent/LT3169772T/lt unknown
- 2015-07-14 WO PCT/EP2015/066083 patent/WO2016008895A1/en active Application Filing
- 2015-07-14 NZ NZ728022A patent/NZ728022A/en unknown
- 2015-07-14 SG SG11201700269WA patent/SG11201700269WA/en unknown
- 2015-07-14 US US15/326,213 patent/US10472608B2/en active Active
- 2015-07-14 ES ES15736516T patent/ES2817848T3/es active Active
- 2015-07-14 UA UAA201700460A patent/UA122562C2/uk unknown
- 2015-07-14 RS RS20201112A patent/RS60863B1/sr unknown
- 2015-07-14 BR BR112017000690-1A patent/BR112017000690B1/pt active IP Right Grant
- 2015-07-14 KR KR1020177003453A patent/KR102408357B1/ko active IP Right Grant
- 2015-07-14 HU HUE15736516A patent/HUE050579T2/hu unknown
- 2015-07-14 SI SI201531352T patent/SI3169772T1/sl unknown
- 2015-07-14 JP JP2017502872A patent/JP6756701B2/ja active Active
- 2015-07-14 PT PT157365164T patent/PT3169772T/pt unknown
- 2015-07-14 AU AU2015289218A patent/AU2015289218B2/en active Active
- 2015-07-14 CA CA2954505A patent/CA2954505C/en active Active
- 2015-07-14 EP EP15736516.4A patent/EP3169772B1/en active Active
- 2015-07-14 DK DK15736516.4T patent/DK3169772T3/da active
- 2015-07-14 CN CN201580038282.7A patent/CN106536719B/zh active Active
- 2015-07-14 EA EA201790025A patent/EA037412B1/ru unknown
- 2015-07-14 EP EP20166228.5A patent/EP3736328A1/en active Pending
- 2015-07-14 PL PL15736516T patent/PL3169772T3/pl unknown
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2017
- 2017-01-03 IL IL24991617A patent/IL249916B/en active IP Right Grant
- 2017-01-14 SA SA517380722A patent/SA517380722B1/ar unknown
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2019
- 2019-09-27 US US16/586,302 patent/US20200231935A1/en not_active Abandoned
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2020
- 2020-09-18 HR HRP20201487TT patent/HRP20201487T1/hr unknown
- 2020-09-21 CY CY20201100886T patent/CY1123343T1/el unknown
-
2023
- 2023-02-02 US US18/104,924 patent/US20230407263A1/en active Pending
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Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
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