BR112016002040A2 - meio condicionado derivado de células estromais, método de obtenção das ditas composições de meio condicionado, formulações e aplicações dos mesmos - Google Patents

meio condicionado derivado de células estromais, método de obtenção das ditas composições de meio condicionado, formulações e aplicações dos mesmos

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Publication number
BR112016002040A2
BR112016002040A2 BR112016002040A BR112016002040A BR112016002040A2 BR 112016002040 A2 BR112016002040 A2 BR 112016002040A2 BR 112016002040 A BR112016002040 A BR 112016002040A BR 112016002040 A BR112016002040 A BR 112016002040A BR 112016002040 A2 BR112016002040 A2 BR 112016002040A2
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BR
Brazil
Prior art keywords
conditioned medium
obtaining
formulations
applications
conditioned
Prior art date
Application number
BR112016002040A
Other languages
English (en)
Inventor
Sen Majumdar Anish
Thej Charan
Ramchandra Bhonde Ramesh
Neelavar Seetharam Raviraja
Balasubramanian Sudha
Sundar Raj Swathi
Original Assignee
Stempeutics Res Pvt Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stempeutics Res Pvt Ltd filed Critical Stempeutics Res Pvt Ltd
Publication of BR112016002040A2 publication Critical patent/BR112016002040A2/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A61K8/981—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2066—IL-10
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/592—Mixtures of compounds complementing their respective functions
    • A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1352—Mesenchymal stem cells
    • C12N2502/1358—Bone marrow mesenchymal stem cells (BM-MSC)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1394—Bone marrow stromal cells; whole marrow

Abstract

resumo “meio condicionado derivado de células estromais, método de obtenção das ditas composições de meio condicionado, formulações e aplicações dos mesmos” meio condicionado (cm) enriquecido com fator bioativo, sua composição e o método de produção do cm são revelados. o método de obtenção da quantidade desejada de fatores bioativos em meio condicionado compreende agrupar células-tronco/estromais mesenquimais derivadas de medula óssea, cultivar as células agrupadas e submeter a cultura celular a uma programação de alimentação de célula em confluência especificada e coletar o meio condicionado potente rico em fatores bioativos em passagem/período de tempo específico. o método visa, ainda, a maximizar a probabilidade de geração de um meio condicionado com variabilidade biológica reduzida e que compreende um grande número de fatores bioativos que têm propriedade/função biológica específica. a revelação também se refere a uma composição e formulação do meio condicionado e seu uso em áreas terapêuticas e cosméticas. 1/1
BR112016002040A 2013-08-29 2014-06-18 meio condicionado derivado de células estromais, método de obtenção das ditas composições de meio condicionado, formulações e aplicações dos mesmos BR112016002040A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN3867CH2013 2013-08-29
PCT/IB2014/062341 WO2015028900A1 (en) 2013-08-29 2014-06-18 Stromal cells derived conditioned medium, method of obtaining said conditioned medium compositions, formulations and applications thereof

Publications (1)

Publication Number Publication Date
BR112016002040A2 true BR112016002040A2 (pt) 2017-08-01

Family

ID=51355569

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112016002040A BR112016002040A2 (pt) 2013-08-29 2014-06-18 meio condicionado derivado de células estromais, método de obtenção das ditas composições de meio condicionado, formulações e aplicações dos mesmos

Country Status (13)

Country Link
US (1) US20160206550A1 (pt)
EP (1) EP3039124A1 (pt)
JP (1) JP2016528911A (pt)
CN (1) CN105473709A (pt)
AU (1) AU2014313874A1 (pt)
BR (1) BR112016002040A2 (pt)
HK (1) HK1217514A1 (pt)
IL (1) IL243530A0 (pt)
MX (1) MX2016002084A (pt)
MY (1) MY186324A (pt)
PH (1) PH12016500252B1 (pt)
SG (1) SG11201600219TA (pt)
WO (1) WO2015028900A1 (pt)

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AU2015355188B2 (en) * 2014-12-01 2021-08-26 Northeast Ohio Medical University CAMKK1 as a novel regenerative therapeutic
RU2644650C2 (ru) 2014-12-01 2018-02-13 Общество с ограниченной ответственностью "Т-Хелпер Клеточные Технологии" Материал стволовых клеток и способ его получения
CN105168085B (zh) * 2015-09-08 2018-08-31 严芳 间充质干细胞衍生液及其制备方法和在化妆品中的应用
US10420802B2 (en) 2015-12-10 2019-09-24 Aesthetics Biomedical, Inc. Topical formulation for skin care
CN105543313B (zh) * 2015-12-29 2019-12-17 四川新生命干细胞科技股份有限公司 一种人源间充质干细胞因子及其制备方法和用途
JP6401818B2 (ja) * 2016-04-27 2018-10-10 株式会社金太郎ＣｅｌｌｓＰｏｗｅｒ 活性化幹細胞製造方法
MY186453A (en) * 2016-04-27 2021-07-22 Kintarocellspower Co Ltd Method for producing activated stem cells
US10988731B2 (en) * 2016-04-29 2021-04-27 Hope Biosciences, Llc Formulation for storage, transportation, and delivery of protein rich conditioned medium
RU2708329C2 (ru) 2016-05-31 2019-12-05 Общество с ограниченной ответственностью "Т-Хелпер Клеточные Технологии" Материал стволовых клеток, композиции и способы применения
CN110267668A (zh) * 2016-11-18 2019-09-20 思卡赛尔治疗公司 可用于治疗免疫相关疾病的组合物
KR101971942B1 (ko) * 2017-08-25 2019-04-24 연세대학교 산학협력단 중간엽 줄기세포 유래 분비 단백체를 포함하는 루푸스의 예방 또는 치료용 약제학적 조성물
GB2568928B (en) * 2017-12-01 2023-03-08 Young Cell Biomedical Tech Inc Neuroprotective composition, preparation process thereof and medical uses thereof
KR102121042B1 (ko) * 2017-12-06 2020-06-09 이정복 조류의 에그로부터 분리한 세포인 배반엽 전분화능세포, 신경줄기세포, 배아섬유아세포 컨디션드 배지를 유효성분으로 하는 세포 증식, 피부재생 및 주름 개선용 배지 조성물
CN109010368B (zh) * 2018-08-01 2021-09-03 徐妍 用于治疗“女运动员三联征”和修复女运动员卵巢功能的细胞制剂及其制备方法
WO2020115823A1 (ja) * 2018-12-04 2020-06-11 一般社団法人 幹細胞総合研究所 幹細胞またはｉＰＳ細胞の培養上清液を用いた化粧品の原料の製造方法
CN109486879A (zh) * 2018-12-06 2019-03-19 上海景峰制药有限公司 一种透明质酸钠及其发酵方法
CN113194968A (zh) * 2018-12-17 2021-07-30 Scm生命科学有限公司 包含克隆干细胞的用于治疗移植物抗宿主疾病的药学组合物
KR20220094194A (ko) * 2019-09-20 2022-07-05 베이징 인스티튜트 포 스템 셀 앤드 리제너레이티브 메디슨 다능성 줄기 세포, 약제학적 조성물, 및 이의 제조 방법 및 이의 적용
CH716227B1 (it) * 2020-04-16 2020-11-30 Contrad Swiss Sa Composizione in gel per applicazione topica per la riduzione dell'infiammazione locale.
TW202146034A (zh) * 2020-05-05 2021-12-16 美國商加速生物科學有限公司 包含有分泌蛋白體的藥學與化妝品組成物
CN116249539A (zh) * 2020-09-03 2023-06-09 学校法人自治医科大学 间充质干细胞或自其衍生的前体细胞的培养上清的净化浓缩物及其制造方法
CN112430626A (zh) * 2020-11-27 2021-03-02 成都康景生物科技有限公司 一种基因修饰的脐间充质干细胞、制备方法及应用
CN114569702B (zh) * 2022-03-07 2022-10-18 上海揽微赛尔生物科技有限公司 含有抗衰老活性肽与干细胞的药物组合物
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Also Published As

Publication number Publication date
AU2014313874A1 (en) 2016-02-25
HK1217514A1 (zh) 2017-01-13
MY186324A (en) 2021-07-09
PH12016500252A1 (en) 2016-05-16
EP3039124A1 (en) 2016-07-06
MX2016002084A (es) 2016-06-23
WO2015028900A1 (en) 2015-03-05
CN105473709A (zh) 2016-04-06
SG11201600219TA (en) 2016-02-26
JP2016528911A (ja) 2016-09-23
US20160206550A1 (en) 2016-07-21
IL243530A0 (en) 2016-03-31
PH12016500252B1 (en) 2016-05-16

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]