BR112016024624B1 - Produto de combinação para detectar marcador alvo, método para detectar um marcador alvo em uma amostra biológica obtida de um indivíduo e uso de um produto de combinação para detectar um marcador alvo em uma amostra biológica - Google Patents

Produto de combinação para detectar marcador alvo, método para detectar um marcador alvo em uma amostra biológica obtida de um indivíduo e uso de um produto de combinação para detectar um marcador alvo em uma amostra biológica Download PDF

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Publication number
BR112016024624B1
BR112016024624B1 BR112016024624-1A BR112016024624A BR112016024624B1 BR 112016024624 B1 BR112016024624 B1 BR 112016024624B1 BR 112016024624 A BR112016024624 A BR 112016024624A BR 112016024624 B1 BR112016024624 B1 BR 112016024624B1
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Brazil
Prior art keywords
binding
binding agent
binding molecule
molecule
labeling substance
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BR112016024624-1A
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English (en)
Portuguese (pt)
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BR112016024624A2 (pt
Inventor
Hirokazu Ohbayashi
Kayoko FUJITA
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Nichirei Biosciences Inc.
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Publication of BR112016024624A2 publication Critical patent/BR112016024624A2/pt
Publication of BR112016024624B1 publication Critical patent/BR112016024624B1/pt

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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5306Improving reaction conditions, e.g. reduction of non-specific binding, promotion of specific binding
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C12Q1/28Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving peroxidase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/42Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving phosphatase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531Production of immunochemical test materials
    • G01N33/532Production of labelled immunochemicals
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531Production of immunochemical test materials
    • G01N33/532Production of labelled immunochemicals
    • G01N33/535Production of labelled immunochemicals with enzyme label or co-enzymes, co-factors, enzyme inhibitors or enzyme substrates
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/581Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with enzyme label (including co-enzymes, co-factors, enzyme inhibitors or substrates)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854Immunoglobulins
    • G01N33/6857Antibody fragments

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
BR112016024624-1A 2014-04-23 2015-04-23 Produto de combinação para detectar marcador alvo, método para detectar um marcador alvo em uma amostra biológica obtida de um indivíduo e uso de um produto de combinação para detectar um marcador alvo em uma amostra biológica BR112016024624B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2014089675 2014-04-23
JP2014-089675 2014-04-23
PCT/JP2015/062423 WO2015163424A1 (ja) 2014-04-23 2015-04-23 標的マーカー検出用組合せ物

Publications (2)

Publication Number Publication Date
BR112016024624A2 BR112016024624A2 (pt) 2017-08-15
BR112016024624B1 true BR112016024624B1 (pt) 2023-10-24

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BR112016024624-1A BR112016024624B1 (pt) 2014-04-23 2015-04-23 Produto de combinação para detectar marcador alvo, método para detectar um marcador alvo em uma amostra biológica obtida de um indivíduo e uso de um produto de combinação para detectar um marcador alvo em uma amostra biológica

Country Status (8)

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US (2) US10324084B2 (US20080131398A1-20080605-C00009.png)
EP (1) EP3136096B1 (US20080131398A1-20080605-C00009.png)
JP (2) JP6019254B2 (US20080131398A1-20080605-C00009.png)
KR (1) KR102190207B1 (US20080131398A1-20080605-C00009.png)
CN (1) CN106233142B (US20080131398A1-20080605-C00009.png)
BR (1) BR112016024624B1 (US20080131398A1-20080605-C00009.png)
RU (1) RU2678108C2 (US20080131398A1-20080605-C00009.png)
WO (1) WO2015163424A1 (US20080131398A1-20080605-C00009.png)

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SE538541C2 (en) * 2015-01-19 2016-09-13 Fogelstrand Per Method for preparing a biological sample for use in an immunolabeling process
FR3044680B1 (fr) * 2015-12-02 2017-12-22 Univ Limoges Methode de detection de cellules souches cancereuses
WO2017204729A1 (en) * 2016-05-25 2017-11-30 Fogelstrand Per Method for preparing a biological sample for use in an immunolabeling process
WO2019197365A1 (en) * 2018-04-09 2019-10-17 Expedeon Ltd. Chemical and biological complexes and conjugates with multiple labels and applications thereof
CN112834736A (zh) * 2020-12-02 2021-05-25 杭州百凌生物科技有限公司 一种检测多种抗原的病理检测试剂盒及其制备方法和应用
CN113588936A (zh) * 2021-06-30 2021-11-02 株洲市中医伤科医院 用于纸质酶联免疫吸附测定的酶标板的制作方法

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GB2098730B (en) * 1981-04-21 1985-02-06 Welsh Nat School Med Immunolocalisation
US4657853A (en) * 1984-09-14 1987-04-14 E. I. Du Pont De Nemours And Company Immunoassays utilizing covalent conjugates of polymerized enzyme and antibody
EP0752102B1 (fr) 1995-01-23 2000-11-15 Pasteur Sanofi Diagnostics Conjugue immunoenzymatique, son procede de preparation et ses applications
JP3524401B2 (ja) 1998-09-16 2004-05-10 株式会社ニチレイ 酵素抗体複合体およびその製造方法
JP3781934B2 (ja) 1999-12-22 2006-06-07 株式会社ニチレイバイオサイエンス 酵素−タンパク質複合体
JP4422291B2 (ja) * 2000-04-21 2010-02-24 大日精化工業株式会社 ヒトメダラシンの免疫学的測定方法
DE60238928D1 (de) 2001-09-19 2011-02-24 Masaaki Kai Lumineszierendes polymer und seine verwendung im bioassay
EP1697750B1 (en) * 2003-12-01 2013-03-20 Dako Denmark A/S Methods and compositions for immuno-histochemical detection
EP1712915B1 (en) 2004-02-03 2011-08-24 Asahi Kasei Kabushiki Kaisha Method of detecting analyte with use of magnetic bead
JP4982687B2 (ja) * 2004-12-09 2012-07-25 株式会社テクノネットワーク四国 標識分子含有シリカ球の調製方法
CA2714212A1 (en) * 2008-02-12 2009-08-20 Novartis Ag Method for isolating cell free apoptotic or fetal nucleic acids
US9671400B2 (en) 2009-02-19 2017-06-06 Dako Denmark A/S Conjugate molecules
RU2546293C2 (ru) 2010-02-05 2015-04-10 Нитирей Байосайенсиз Инк. Раствор для предварительной обработки для иммуногистохимического окрашивания и конденсированный раствор
CN101833000A (zh) 2010-05-13 2010-09-15 北京海瑞祥天生物科技有限公司 高效级联放大的抗体检测法
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Publication number Publication date
CN106233142B (zh) 2019-03-08
US20190324020A1 (en) 2019-10-24
RU2016145600A (ru) 2018-05-25
JP6293837B2 (ja) 2018-03-14
JP6019254B2 (ja) 2016-11-02
JP2017026631A (ja) 2017-02-02
US10324084B2 (en) 2019-06-18
JPWO2015163424A1 (ja) 2017-04-20
WO2015163424A1 (ja) 2015-10-29
RU2016145600A3 (US20080131398A1-20080605-C00009.png) 2018-05-25
EP3136096A1 (en) 2017-03-01
US20170045502A1 (en) 2017-02-16
CN106233142A (zh) 2016-12-14
BR112016024624A2 (pt) 2017-08-15
US11156602B2 (en) 2021-10-26
RU2678108C2 (ru) 2019-01-23
EP3136096A4 (en) 2017-09-13
KR102190207B1 (ko) 2020-12-15
EP3136096B1 (en) 2021-12-01
KR20160147830A (ko) 2016-12-23

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