BR112016023004A2 - sirna, estrutura oligo rna de fita dupla, nanopartícula, composição farmacêutica e estrutura liofilizada para prevenir ou tratar fibrose ou doenças respiratórias contendo a mesma - Google Patents

sirna, estrutura oligo rna de fita dupla, nanopartícula, composição farmacêutica e estrutura liofilizada para prevenir ou tratar fibrose ou doenças respiratórias contendo a mesma

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Publication number
BR112016023004A2
BR112016023004A2 BR112016023004-3A BR112016023004A BR112016023004A2 BR 112016023004 A2 BR112016023004 A2 BR 112016023004A2 BR 112016023004 A BR112016023004 A BR 112016023004A BR 112016023004 A2 BR112016023004 A2 BR 112016023004A2
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Brazil
Prior art keywords
double
sirna
pharmaceutical composition
prevent
stranded oligo
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BR112016023004-3A
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English (en)
Korean (ko)
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BR112016023004B1 (pt
Inventor
CHAE Jeiwook
Oh Yoon Pyoung
Han Boram
Na KIM Mi
KO Youngho
Oh Park Han
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Bioneer Corporation
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Publication of BR112016023004A2 publication Critical patent/BR112016023004A2/pt
Publication of BR112016023004B1 publication Critical patent/BR112016023004B1/pt

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Abstract

a presente invenção refere-se a sirna, estrutura de oligo rna de fita dupla, nanopartícula, composição farmacêutica e estrutura liofilizada para prevenir ou tratar fibrose ou doenças respiratórias, em que a estrutura oligo rna de fita dupla é onde o material hidrofílico e um material hidrofóbico são conjugados a ambos os terminais do rna de fita dupla (sirna) através de uma ligação covalente simples ou ligação covalente mediada por ligante para eficientemente transportar a estrutura de rna de fita dupla nas células, podendo a estrutura de rna de fita dupla ser mudada para uma forma de nanopartículas em uma solução aquosa devido à interação hidrofóbica entre as estruturas de rna de fita dupla. o sirna incluído na estrutura de oligo rna de fita dupla é preferencialmente sirna específico para fibrose ? ou um gene associado à doença respiratória - particularmente, anfiregulina ou estratifina. ainda, a presente invenção refere-se a uma composição farmacêutica compreendendo sirna, e uma estrutura de oligo rna de fita dupla altamente eficiente e nanopartículas compreendendo a mesma, como um ingrediente ativo para prevenir ou tratar fibrose ou doenças respiratórias.
BR112016023004-3A 2014-04-04 2015-04-06 Sirna, estrutura oligo rna de fita dupla, nanopartícula, composição farmacêutica e estrutura liofilizada para prevenir ou tratar fibrose ou doenças respiratórias contendo a mesma BR112016023004B1 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR10-2014-0040699 2014-04-04
KRKR10-2014-0040699 2014-04-04
KR20140040699 2014-04-04
PCT/KR2015/003400 WO2015152693A2 (ko) 2014-04-04 2015-04-06 신규 이중 나선 올리고 rna 및 이를 포함하는 섬유증 또는 호흡기 질환의 예방 또는 치료용 약학조성물

Publications (2)

Publication Number Publication Date
BR112016023004A2 true BR112016023004A2 (pt) 2018-07-03
BR112016023004B1 BR112016023004B1 (pt) 2023-12-05

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BR112016023004-3A BR112016023004B1 (pt) 2014-04-04 2015-04-06 Sirna, estrutura oligo rna de fita dupla, nanopartícula, composição farmacêutica e estrutura liofilizada para prevenir ou tratar fibrose ou doenças respiratórias contendo a mesma

Country Status (7)

Country Link
US (1) US10208309B2 (pt)
EP (1) EP3128008B1 (pt)
JP (1) JP6426268B2 (pt)
KR (1) KR102208588B1 (pt)
CN (2) CN112159807A (pt)
BR (1) BR112016023004B1 (pt)
WO (1) WO2015152693A2 (pt)

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CN106459974A (zh) 2017-02-22
EP3128008A2 (en) 2017-02-08
EP3128008A4 (en) 2018-03-28
KR102208588B1 (ko) 2021-01-28
EP3128008B1 (en) 2024-05-29
JP2017512502A (ja) 2017-05-25
WO2015152693A3 (ko) 2015-11-26
US10208309B2 (en) 2019-02-19
CN112159807A (zh) 2021-01-01
EP3128008C0 (en) 2024-05-29
BR112016023004B1 (pt) 2023-12-05
JP6426268B2 (ja) 2018-11-21
KR20150115687A (ko) 2015-10-14
WO2015152693A2 (ko) 2015-10-08
US20170130231A1 (en) 2017-05-11

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