BR112016011930A2 - combinações de peptídeos e seus usos em tratamento de alergia de ácaro de poeira - Google Patents

combinações de peptídeos e seus usos em tratamento de alergia de ácaro de poeira

Info

Publication number
BR112016011930A2
BR112016011930A2 BR112016011930A BR112016011930A BR112016011930A2 BR 112016011930 A2 BR112016011930 A2 BR 112016011930A2 BR 112016011930 A BR112016011930 A BR 112016011930A BR 112016011930 A BR112016011930 A BR 112016011930A BR 112016011930 A2 BR112016011930 A2 BR 112016011930A2
Authority
BR
Brazil
Prior art keywords
dust mite
peptide combinations
der
combinations
mite allergy
Prior art date
Application number
BR112016011930A
Other languages
English (en)
Inventor
Sette Alessandro
Lundegaard Claus
Lund Gitte
Sidney John
Harder CHRISTENSEN Lars
Adler WÜRTZEN Peter
Original Assignee
Alk Abello As
La Jolla Inst Allergy & Immunology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alk Abello As, La Jolla Inst Allergy & Immunology filed Critical Alk Abello As
Publication of BR112016011930A2 publication Critical patent/BR112016011930A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/35—Allergens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
    • C07K14/43531—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from mites
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Insects & Arthropods (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

a presente invenção refere-se a combinações de peptídeos ou suas variantes derivadas de uma porção de uma sequência de aminoácidos de um alérgeno de ácaro de poeira doméstica, por exemplo, os alérgenos der p 1, der f 1, der p 2, e/ou der f 2. tais peptídeos compreendem pelo menos um epitopo de célula t e um número alto significante de pacientes em uma população mundial terá alelos hla com o potencial para ligação de peptídeos das combinações de peptídeos. a invenção também refere-se ao uso de tais combinações de peptídeos em alívio de uma resposta imune causada por um ácaro de poeira.
BR112016011930A 2013-12-23 2014-12-23 combinações de peptídeos e seus usos em tratamento de alergia de ácaro de poeira BR112016011930A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361919925P 2013-12-23 2013-12-23
US201462012690P 2014-06-16 2014-06-16
PCT/US2014/072228 WO2015100360A1 (en) 2013-12-23 2014-12-23 Peptide combinations and uses thereof in treating dust mite allergy

Publications (1)

Publication Number Publication Date
BR112016011930A2 true BR112016011930A2 (pt) 2017-09-26

Family

ID=52293308

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112016011930A BR112016011930A2 (pt) 2013-12-23 2014-12-23 combinações de peptídeos e seus usos em tratamento de alergia de ácaro de poeira

Country Status (12)

Country Link
US (1) US10059751B2 (pt)
EP (1) EP3086806B1 (pt)
JP (1) JP2017507906A (pt)
KR (1) KR20160096206A (pt)
CN (1) CN105848677B (pt)
AU (1) AU2014369866A1 (pt)
BR (1) BR112016011930A2 (pt)
CA (1) CA2933552A1 (pt)
EA (1) EA201691306A1 (pt)
MX (1) MX2016008305A (pt)
SG (1) SG11201604892YA (pt)
WO (1) WO2015100360A1 (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9265824B2 (en) * 2010-06-03 2016-02-23 Alk-Abello A/S Pharmaceutical product comprising mite allergen extract(s) and a method for the manufacture thereof
WO2017004561A1 (en) 2015-07-01 2017-01-05 Alk-Abelló A/S Peptide combinations and uses thereof for treating grass allergy
WO2017096247A1 (en) * 2015-12-04 2017-06-08 Mayo Foundation For Medical Education And Research Methods and vaccines for inducing immune responses to multiple different mhc molecules
WO2017203057A1 (en) * 2016-05-27 2017-11-30 Alk-Abelló A/S Immunogenic proteins and fragments thereof from allergenic mites
CN108265059B (zh) 2016-12-31 2021-01-05 江苏众红生物工程创药研究院有限公司 一种重组粉尘螨2类变应原蛋白及其制备方法与应用
CN107338261B (zh) * 2017-07-17 2023-04-07 海南大学 热带无爪螨重组变应原Blot5-21、其制备方法及过敏小鼠模型的建立
US20220395584A1 (en) * 2019-03-14 2022-12-15 Engene, Inc Reversible coating of chitosan-nucleic acid nanoparticles and methods of their use
CN113125753B (zh) * 2021-04-16 2022-07-26 杭州浙大迪迅生物基因工程有限公司 一种用于检测尘螨组分特异性抗体的试剂盒

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PT100978B (pt) 1991-10-16 1999-10-29 Immulogic Pharma Corp Peptidos recombitope, sequencias de acidos nucleicos que os codificam, composicoes terapeuticas que os contem, processo para a sua concepcao e sue uso.
US7288256B1 (en) 1991-10-16 2007-10-30 Merck Patent Gmbh T cell epitopes of the major allergens from dermatophagoides (house dust mite)
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US5968526A (en) * 1994-04-14 1999-10-19 Immulogic Pharamaceutical Corporation T cell epitopes of the major allergens from Dermatophagoides (house dust mite)
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WO2005049107A2 (en) 2003-11-18 2005-06-02 Nanapass Technologies Ltd. Enhanced penetration system and method for sliding microneedles
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JP2010512170A (ja) 2005-12-08 2010-04-22 ナノパス テクノロジーズ エルティディ． 薬剤投与器用マイクロ・ニードル・アダプタ
PL2059256T3 (pl) * 2006-08-11 2017-02-28 Life Sciences Research Partners Vzw Immunogenne peptydy i ich zastosowanie w zaburzeniach immunologicznych
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PL2717910T3 (pl) 2011-06-09 2019-07-31 Biomay Ag Białka fuzyjne peptydów nośnikowych jako szczepionki przeciwalergiczne
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BR112014019504A2 (pt) 2012-02-07 2017-06-27 La Jolla Inst Allergy & Immunology alérgenos da erva-dos-prados e métodos e usos para modulação de resposta imune
EP2812028A4 (en) * 2012-02-07 2016-01-06 Jolla Inst Allergy Immunolog EPITOPES OF ALLERGENIC PROTEINS AND METHOD AND USE TO IMMUNE REACTION MODULATION
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US20140350514A1 (en) 2013-05-22 2014-11-27 Nanopass Technologies Ltd. Systems and methods for intradermal delivery of therapeutics using microneedles

Also Published As

Publication number Publication date
EA201691306A1 (ru) 2016-10-31
MX2016008305A (es) 2017-01-11
SG11201604892YA (en) 2016-07-28
US20160251403A1 (en) 2016-09-01
EP3086806A1 (en) 2016-11-02
CA2933552A1 (en) 2015-07-02
CN105848677A (zh) 2016-08-10
EP3086806B1 (en) 2019-12-11
JP2017507906A (ja) 2017-03-23
KR20160096206A (ko) 2016-08-12
WO2015100360A1 (en) 2015-07-02
AU2014369866A1 (en) 2016-06-30
CN105848677B (zh) 2020-01-31
US10059751B2 (en) 2018-08-28

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal acc. article 33 of ipl - extension of time limit for request of examination expired
B350 Update of information on the portal [chapter 15.35 patent gazette]