BR112014017862A2 - epitopos modificados para aumento de respostas de célula t cd4+ - Google Patents

epitopos modificados para aumento de respostas de célula t cd4+

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Publication number
BR112014017862A2
BR112014017862A2 BR112014017862A BR112014017862A BR112014017862A2 BR 112014017862 A2 BR112014017862 A2 BR 112014017862A2 BR 112014017862 A BR112014017862 A BR 112014017862A BR 112014017862 A BR112014017862 A BR 112014017862A BR 112014017862 A2 BR112014017862 A2 BR 112014017862A2
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BR
Brazil
Prior art keywords
cell responses
peptides
modified
cysteine
increasing
Prior art date
Application number
BR112014017862A
Other languages
English (en)
Inventor
Marie Saint Remy Jean
Original Assignee
Univ Leuven Kath
Life Sciences Res Partners Vzw
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Publication date
Application filed by Univ Leuven Kath, Life Sciences Res Partners Vzw filed Critical Univ Leuven Kath
Publication of BR112014017862A2 publication Critical patent/BR112014017862A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
    • C07K14/43531—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from mites
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/04—Mycobacterium, e.g. Mycobacterium tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/35—Allergens
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/463—Cellular immunotherapy characterised by recombinant expression
    • A61K39/4632—T-cell receptors [TCR]; antibody T-cell receptor constructs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A61K39/464454—Enzymes
    • A61K39/464462—Kinases, e.g. Raf or Src
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    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4648—Bacterial antigens
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P31/04—Antibacterial agents
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    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4713—Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens
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    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C12N5/0637—Immunosuppressive T lymphocytes, e.g. regulatory T cells or Treg
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    • A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
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    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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Abstract

resumo patente de invenção para "epitopos modificados para aumento de respostas de célula t cd4+". a presente invenção refere-se a peptídeos imunogênicos compreendendo um epitopo de célula t. referidos peptídeos são modificados, tal que respostas de célula t cd4+ são obtidas, que são muito mais fortes do que as respostas de célula t cd4+ obtidas com os mesmos peptídeos não compreendendo referida modificação. em particular, a modificação é a adição de uma cisteína, inserção de uma cisteína, ou mutação em uma cisteína, de um resíduo em uma posição adjacente a, mas fora do local de ligação de mhc do peptídeo. adicionalmente revelados são: o uso de tais peptídeos modificados no tratamento, supressão ou prevenção de doenças, tais como doenças infecciosas ou doenças alérgicas, e doença autoimunes, na prevenção ou supressão de rejeição de enxerto, ou na erradicação de células de tumor.
BR112014017862A 2012-01-30 2013-01-30 epitopos modificados para aumento de respostas de célula t cd4+ BR112014017862A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261592404P 2012-01-30 2012-01-30
GBGB1201511.1A GB201201511D0 (en) 2012-01-30 2012-01-30 Modified epitopes for boosting CD4+ T-cell responses
PCT/BE2013/000006 WO2013113076A1 (en) 2012-01-30 2013-01-30 Modified epitopes for boosting cd4+ t-cell responses

Publications (1)

Publication Number Publication Date
BR112014017862A2 true BR112014017862A2 (pt) 2017-06-27

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BR112014017862A BR112014017862A2 (pt) 2012-01-30 2013-01-30 epitopos modificados para aumento de respostas de célula t cd4+

Country Status (13)

Country Link
US (2) US10899795B2 (pt)
EP (2) EP2809332A1 (pt)
JP (2) JP6285368B2 (pt)
KR (2) KR102228843B1 (pt)
CN (1) CN104220080B (pt)
AU (1) AU2013214700B2 (pt)
BR (1) BR112014017862A2 (pt)
CA (1) CA2863126A1 (pt)
GB (1) GB201201511D0 (pt)
HK (1) HK1204283A1 (pt)
RU (1) RU2724994C2 (pt)
WO (1) WO2013113076A1 (pt)
ZA (1) ZA201405197B (pt)

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RU2724994C2 (ru) 2020-06-29
KR102228843B1 (ko) 2021-03-18
HK1204283A1 (en) 2015-11-13
ZA201405197B (en) 2015-10-28
CA2863126A1 (en) 2013-08-08
EP2809332A1 (en) 2014-12-10
RU2014135406A (ru) 2016-03-27
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JP6285368B2 (ja) 2018-02-28
CN104220080A (zh) 2014-12-17
AU2013214700B2 (en) 2017-09-28
WO2013113076A1 (en) 2013-08-08
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US20210188913A1 (en) 2021-06-24
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US10899795B2 (en) 2021-01-26
US20140370044A1 (en) 2014-12-18
JP2018076329A (ja) 2018-05-17

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