EA201691306A1 - Пептидные комбинации и их применение при лечении аллергии на клещей домашней пыли - Google Patents

Пептидные комбинации и их применение при лечении аллергии на клещей домашней пыли

Info

Publication number
EA201691306A1
EA201691306A1 EA201691306A EA201691306A EA201691306A1 EA 201691306 A1 EA201691306 A1 EA 201691306A1 EA 201691306 A EA201691306 A EA 201691306A EA 201691306 A EA201691306 A EA 201691306A EA 201691306 A1 EA201691306 A1 EA 201691306A1
Authority
EA
Eurasian Patent Office
Prior art keywords
der
allergy
claw
treatment
peptides
Prior art date
Application number
EA201691306A
Other languages
English (en)
Inventor
Клаус Лундегорд
Ларс Хардер Кристенсен
Петер Адлер Вюртцен
Алессандро Сетте
Джон Сидни
Гитте Лунд
Original Assignee
Альк-Абелло А/С
Ла Хойя Инститьют Фор Эллерджи Энд Иммьюнолоджи
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Альк-Абелло А/С, Ла Хойя Инститьют Фор Эллерджи Энд Иммьюнолоджи filed Critical Альк-Абелло А/С
Publication of EA201691306A1 publication Critical patent/EA201691306A1/ru

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/35—Allergens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
    • C07K14/43531—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from mites
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Insects & Arthropods (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Изобретение относится к комбинациям пептидов или их вариантов, полученных из части аминокислотной последовательности аллергена клеща домашней пыли, например аллергенов Der p 1, Der f 1, Der p 2 и/или Der f 2. Такие пептиды содержат по меньшей мере один Т-клеточный эпитоп, и значительно большое число пациентов в мировой популяции будет иметь аллели HLA с потенциалом связывания с пептидами пептидных комбинаций. Настоящее изобретение также относится к применению таких пептидных комбинаций при ослаблении иммунного ответа, вызываемого пылевыми клещами.
EA201691306A 2013-12-23 2014-12-23 Пептидные комбинации и их применение при лечении аллергии на клещей домашней пыли EA201691306A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361919925P 2013-12-23 2013-12-23
US201462012690P 2014-06-16 2014-06-16
PCT/US2014/072228 WO2015100360A1 (en) 2013-12-23 2014-12-23 Peptide combinations and uses thereof in treating dust mite allergy

Publications (1)

Publication Number Publication Date
EA201691306A1 true EA201691306A1 (ru) 2016-10-31

Family

ID=52293308

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201691306A EA201691306A1 (ru) 2013-12-23 2014-12-23 Пептидные комбинации и их применение при лечении аллергии на клещей домашней пыли

Country Status (12)

Country Link
US (1) US10059751B2 (ru)
EP (1) EP3086806B1 (ru)
JP (1) JP2017507906A (ru)
KR (1) KR20160096206A (ru)
CN (1) CN105848677B (ru)
AU (1) AU2014369866A1 (ru)
BR (1) BR112016011930A2 (ru)
CA (1) CA2933552A1 (ru)
EA (1) EA201691306A1 (ru)
MX (1) MX2016008305A (ru)
SG (1) SG11201604892YA (ru)
WO (1) WO2015100360A1 (ru)

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US9265824B2 (en) * 2010-06-03 2016-02-23 Alk-Abello A/S Pharmaceutical product comprising mite allergen extract(s) and a method for the manufacture thereof
US11013781B2 (en) 2015-07-01 2021-05-25 Alk-Abelló As Peptide combinations and uses thereof for treating grass allergy
US11464839B2 (en) 2015-12-04 2022-10-11 Mayo Foundation For Medical Education And Research Methods and vaccines for inducing immune responses to multiple different MHC molecules
WO2017203057A1 (en) * 2016-05-27 2017-11-30 Alk-Abelló A/S Immunogenic proteins and fragments thereof from allergenic mites
CN108265059B (zh) 2016-12-31 2021-01-05 江苏众红生物工程创药研究院有限公司 一种重组粉尘螨2类变应原蛋白及其制备方法与应用
CN107338261B (zh) * 2017-07-17 2023-04-07 海南大学 热带无爪螨重组变应原Blot5-21、其制备方法及过敏小鼠模型的建立
CA3133175A1 (en) * 2019-03-14 2020-09-17 Engene, Inc. Reversible coating of chitosan-nucleic acid nanoparticles and methods of their use
CN113125753B (zh) * 2021-04-16 2022-07-26 杭州浙大迪迅生物基因工程有限公司 一种用于检测尘螨组分特异性抗体的试剂盒

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US5194596A (en) * 1989-07-27 1993-03-16 California Biotechnology Inc. Production of vascular endothelial cell growth factor
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Also Published As

Publication number Publication date
WO2015100360A1 (en) 2015-07-02
KR20160096206A (ko) 2016-08-12
CA2933552A1 (en) 2015-07-02
EP3086806A1 (en) 2016-11-02
MX2016008305A (es) 2017-01-11
US10059751B2 (en) 2018-08-28
BR112016011930A2 (pt) 2017-09-26
CN105848677B (zh) 2020-01-31
JP2017507906A (ja) 2017-03-23
CN105848677A (zh) 2016-08-10
EP3086806B1 (en) 2019-12-11
AU2014369866A1 (en) 2016-06-30
US20160251403A1 (en) 2016-09-01
SG11201604892YA (en) 2016-07-28

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