EA201691306A1 - Пептидные комбинации и их применение при лечении аллергии на клещей домашней пыли - Google Patents
Пептидные комбинации и их применение при лечении аллергии на клещей домашней пылиInfo
- Publication number
- EA201691306A1 EA201691306A1 EA201691306A EA201691306A EA201691306A1 EA 201691306 A1 EA201691306 A1 EA 201691306A1 EA 201691306 A EA201691306 A EA 201691306A EA 201691306 A EA201691306 A EA 201691306A EA 201691306 A1 EA201691306 A1 EA 201691306A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- der
- allergy
- claw
- treatment
- peptides
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/35—Allergens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
- C07K14/43531—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from mites
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Insects & Arthropods (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Изобретение относится к комбинациям пептидов или их вариантов, полученных из части аминокислотной последовательности аллергена клеща домашней пыли, например аллергенов Der p 1, Der f 1, Der p 2 и/или Der f 2. Такие пептиды содержат по меньшей мере один Т-клеточный эпитоп, и значительно большое число пациентов в мировой популяции будет иметь аллели HLA с потенциалом связывания с пептидами пептидных комбинаций. Настоящее изобретение также относится к применению таких пептидных комбинаций при ослаблении иммунного ответа, вызываемого пылевыми клещами.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361919925P | 2013-12-23 | 2013-12-23 | |
US201462012690P | 2014-06-16 | 2014-06-16 | |
PCT/US2014/072228 WO2015100360A1 (en) | 2013-12-23 | 2014-12-23 | Peptide combinations and uses thereof in treating dust mite allergy |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201691306A1 true EA201691306A1 (ru) | 2016-10-31 |
Family
ID=52293308
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201691306A EA201691306A1 (ru) | 2013-12-23 | 2014-12-23 | Пептидные комбинации и их применение при лечении аллергии на клещей домашней пыли |
Country Status (12)
Country | Link |
---|---|
US (1) | US10059751B2 (ru) |
EP (1) | EP3086806B1 (ru) |
JP (1) | JP2017507906A (ru) |
KR (1) | KR20160096206A (ru) |
CN (1) | CN105848677B (ru) |
AU (1) | AU2014369866A1 (ru) |
BR (1) | BR112016011930A2 (ru) |
CA (1) | CA2933552A1 (ru) |
EA (1) | EA201691306A1 (ru) |
MX (1) | MX2016008305A (ru) |
SG (1) | SG11201604892YA (ru) |
WO (1) | WO2015100360A1 (ru) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3662916A1 (en) * | 2010-06-03 | 2020-06-10 | ALK-Abelló A/S | Pharmaceutical product comprising mite allergen extract(s) and a method for the manufacture thereof |
US11013781B2 (en) | 2015-07-01 | 2021-05-25 | Alk-Abelló As | Peptide combinations and uses thereof for treating grass allergy |
US11464839B2 (en) | 2015-12-04 | 2022-10-11 | Mayo Foundation For Medical Education And Research | Methods and vaccines for inducing immune responses to multiple different MHC molecules |
WO2017203057A1 (en) * | 2016-05-27 | 2017-11-30 | Alk-Abelló A/S | Immunogenic proteins and fragments thereof from allergenic mites |
CN108265059B (zh) | 2016-12-31 | 2021-01-05 | 江苏众红生物工程创药研究院有限公司 | 一种重组粉尘螨2类变应原蛋白及其制备方法与应用 |
CN107338261B (zh) * | 2017-07-17 | 2023-04-07 | 海南大学 | 热带无爪螨重组变应原Blot5-21、其制备方法及过敏小鼠模型的建立 |
KR20210151822A (ko) * | 2019-03-14 | 2021-12-14 | 엔진 인코포레이티드 | 키토산-핵산 나노입자의 가역성 코팅 및 이의 사용 방법 |
CN113125753B (zh) * | 2021-04-16 | 2022-07-26 | 杭州浙大迪迅生物基因工程有限公司 | 一种用于检测尘螨组分特异性抗体的试剂盒 |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
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US5194596A (en) * | 1989-07-27 | 1993-03-16 | California Biotechnology Inc. | Production of vascular endothelial cell growth factor |
US5350836A (en) * | 1989-10-12 | 1994-09-27 | Ohio University | Growth hormone antagonists |
WO1994024281A1 (en) | 1993-04-14 | 1994-10-27 | Immulogic Pharmaceutical Corporation | T cell epitopes of the major allergens from dermatophagoides (house dust mite) |
US7288256B1 (en) * | 1991-10-16 | 2007-10-30 | Merck Patent Gmbh | T cell epitopes of the major allergens from dermatophagoides (house dust mite) |
PT100978B (pt) | 1991-10-16 | 1999-10-29 | Immulogic Pharma Corp | Peptidos recombitope, sequencias de acidos nucleicos que os codificam, composicoes terapeuticas que os contem, processo para a sua concepcao e sue uso. |
NZ284637A (en) | 1994-04-14 | 1998-09-24 | Immulogic Pharma Corp | Pharmaceutical formulations for treating dust mite allergy |
US5820862A (en) * | 1994-04-14 | 1998-10-13 | Immulogic Pharmaceutical Corporation | T cell epitopes of the major allergens from dermatophagoides (house dust mite) |
JP2001231563A (ja) * | 2000-02-18 | 2001-08-28 | Asahi Breweries Ltd | 改変したダニアレルゲン(システイン変異体)及びその製造方法 |
JP2007511318A (ja) | 2003-11-18 | 2007-05-10 | ナノ パス テクノロジーズ リミテッド | 改良された挿入システム及びマイクロニードルを摺動させるための方法 |
EP1819379B1 (en) | 2004-11-18 | 2016-08-31 | Nanopass Technologies Ltd. | System for delivering fluid into flexible biological barrier |
EP2559448B1 (en) | 2005-12-08 | 2017-05-31 | Nanopass Technologies Ltd. | Microneedle adapter for dosed drug delivery devices |
EP2476437B1 (en) * | 2006-08-11 | 2018-11-28 | Life Sciences Research Partners VZW | Immunogenic peptides and their use in immune disorders |
KR101699554B1 (ko) * | 2007-08-15 | 2017-01-25 | 서카시아 리미티드 | 백신용 펩티드 |
EP2331124A1 (en) | 2008-08-15 | 2011-06-15 | Circassia Limited | T-cell antigen peptide from allergen for stimulation of il-10 production |
PT2717910T (pt) | 2011-06-09 | 2019-05-22 | Biomay Ag | Proteínas de fusão transportadoras de péptido como vacinas para alergia |
WO2013061290A1 (en) | 2011-10-26 | 2013-05-02 | Nanopass Technologies Ltd. | Microneedle intradermal drug delivery device with auto-disable functionality |
JP2015509487A (ja) * | 2012-02-07 | 2015-03-30 | ラ ホーヤ インスティテュート フォー アレルギー アンド イムノロジーLa Jolla Institute For Allergy And Immunology | アレルゲンタンパク質由来のエピトープ並びに免疫応答モジュレーションのための方法及び使用 |
CN104203277A (zh) | 2012-02-07 | 2014-12-10 | 拉霍拉敏感及免疫学研究所 | 梯牧草变应原和用于调节免疫反应的方法和用途 |
US20130302338A1 (en) | 2012-05-14 | 2013-11-14 | Promd Biotech. Co., Ltd. | Dermatophagoid pteronyssinus (der p1) antigen epitope and anti-der p1 antibody |
US20140350514A1 (en) | 2013-05-22 | 2014-11-27 | Nanopass Technologies Ltd. | Systems and methods for intradermal delivery of therapeutics using microneedles |
-
2014
- 2014-12-23 WO PCT/US2014/072228 patent/WO2015100360A1/en active Application Filing
- 2014-12-23 SG SG11201604892YA patent/SG11201604892YA/en unknown
- 2014-12-23 MX MX2016008305A patent/MX2016008305A/es unknown
- 2014-12-23 EA EA201691306A patent/EA201691306A1/ru unknown
- 2014-12-23 CN CN201480070484.5A patent/CN105848677B/zh active Active
- 2014-12-23 JP JP2016543009A patent/JP2017507906A/ja active Pending
- 2014-12-23 CA CA2933552A patent/CA2933552A1/en not_active Abandoned
- 2014-12-23 US US15/021,775 patent/US10059751B2/en active Active
- 2014-12-23 KR KR1020167020337A patent/KR20160096206A/ko not_active Application Discontinuation
- 2014-12-23 BR BR112016011930A patent/BR112016011930A2/pt not_active Application Discontinuation
- 2014-12-23 AU AU2014369866A patent/AU2014369866A1/en not_active Abandoned
- 2014-12-23 EP EP14824746.3A patent/EP3086806B1/en active Active
Also Published As
Publication number | Publication date |
---|---|
CN105848677B (zh) | 2020-01-31 |
EP3086806A1 (en) | 2016-11-02 |
CA2933552A1 (en) | 2015-07-02 |
AU2014369866A1 (en) | 2016-06-30 |
CN105848677A (zh) | 2016-08-10 |
US20160251403A1 (en) | 2016-09-01 |
JP2017507906A (ja) | 2017-03-23 |
US10059751B2 (en) | 2018-08-28 |
EP3086806B1 (en) | 2019-12-11 |
SG11201604892YA (en) | 2016-07-28 |
MX2016008305A (es) | 2017-01-11 |
WO2015100360A1 (en) | 2015-07-02 |
KR20160096206A (ko) | 2016-08-12 |
BR112016011930A2 (pt) | 2017-09-26 |
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