BR112016002685A2 - ensaios para timp2 que apresentam melhor desempenho em amostras biológicas - Google Patents

ensaios para timp2 que apresentam melhor desempenho em amostras biológicas

Info

Publication number
BR112016002685A2
BR112016002685A2 BR112016002685A BR112016002685A BR112016002685A2 BR 112016002685 A2 BR112016002685 A2 BR 112016002685A2 BR 112016002685 A BR112016002685 A BR 112016002685A BR 112016002685 A BR112016002685 A BR 112016002685A BR 112016002685 A2 BR112016002685 A2 BR 112016002685A2
Authority
BR
Brazil
Prior art keywords
timp2
assays
biological samples
perform better
assay
Prior art date
Application number
BR112016002685A
Other languages
English (en)
Portuguese (pt)
Inventor
A Vijayendran Ravi
VENKATASUBBARAO Srivatsa
Original Assignee
Astute Medical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astute Medical Inc filed Critical Astute Medical Inc
Publication of BR112016002685A2 publication Critical patent/BR112016002685A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/38—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against protease inhibitors of peptide structure
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/577—Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/81—Protease inhibitors
    • G01N2333/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • G01N2333/8146—Metalloprotease (E.C. 3.4.24) inhibitors, e.g. tissue inhibitor of metallo proteinase, TIMP

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
BR112016002685A 2013-08-07 2014-08-07 ensaios para timp2 que apresentam melhor desempenho em amostras biológicas BR112016002685A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361863073P 2013-08-07 2013-08-07
PCT/US2014/050195 WO2015021308A1 (en) 2013-08-07 2014-08-07 Assays for timp2 having improved performance in biological samples

Publications (1)

Publication Number Publication Date
BR112016002685A2 true BR112016002685A2 (pt) 2018-01-30

Family

ID=52461941

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112016002685A BR112016002685A2 (pt) 2013-08-07 2014-08-07 ensaios para timp2 que apresentam melhor desempenho em amostras biológicas

Country Status (12)

Country Link
US (2) US9879091B2 (https=)
EP (2) EP3617234A1 (https=)
JP (1) JP2016528236A (https=)
KR (1) KR20160039682A (https=)
CN (1) CN105531291A (https=)
AU (1) AU2014305883A1 (https=)
BR (1) BR112016002685A2 (https=)
CA (1) CA2920521A1 (https=)
EA (1) EA201690185A1 (https=)
HK (1) HK1222180A1 (https=)
MX (1) MX2016001573A (https=)
WO (1) WO2015021308A1 (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2836218T3 (es) 2008-10-21 2021-06-24 Astute Medical Inc Procedimientos y composiciones para el diagnóstico y pronóstico de lesión renal e insuficiencia renal
WO2011075744A1 (en) 2009-12-20 2011-06-23 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
NZ605698A (en) 2010-06-23 2015-03-27 Astute Medical Inc Methods and compositions for diagnosis and prognosis of renal injury and renal failure
US10935548B2 (en) 2011-12-08 2021-03-02 Astute Medical, Inc. Methods for diagnosis and prognosis of renal injury and renal failure using insulin-like growth factor-binding protein 7 and metalloproteinase inhibitor 2
EP3361255B1 (en) 2013-01-17 2020-03-11 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
CN110007084B (zh) 2013-12-03 2022-11-18 阿斯图特医药公司 用于肾损伤和肾衰竭的诊断和预后的方法和组合物
US11243202B2 (en) 2015-04-09 2022-02-08 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
CN108700609A (zh) * 2015-12-30 2018-10-23 生物辐射实验室股份有限公司 具有自动校准的液滴测定系统
EP3465201A4 (en) 2016-06-06 2020-08-26 Astute Medical, Inc. MANAGEMENT OF ACUTE KIDNEY DAMAGE USING INSULINOMIMETIC GROWTH FACTOR BINDING PROTEIN 7 AND TISSUE METALLOPROTEINASE 2 INHIBITOR
WO2018006049A1 (en) * 2016-06-30 2018-01-04 The Research Foundation For The State University Of New York Compositions and methods for modifying activity of extracellular mmp-2
CN110352073A (zh) * 2016-10-28 2019-10-18 机敏医药股份有限公司 针对timp-2的抗体用于改善肾功能的用途
CN110431422A (zh) 2017-02-06 2019-11-08 机敏医药股份有限公司 用于肾损伤和肾衰竭的诊断和预后的方法和组合物
CN110709103B (zh) * 2017-04-05 2024-02-02 机敏医药股份有限公司 用于生物学样品中具有改善的性能的timp2的测定法
KR20210019459A (ko) 2018-05-24 2021-02-22 레니버스 테라퓨틱스, 인크. 신장 손상 및 신부전 위험이 있는 환자를 치료하는 방법

Family Cites Families (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US459004A (en) 1891-09-08 Box for steaming cops
DE3029579C2 (de) 1980-08-05 1985-12-12 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren und Mittel zur Abtrennung von Plasma oder Serum aus Vollblut
US5807715A (en) 1984-08-27 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5028535A (en) 1989-01-10 1991-07-02 Biosite Diagnostics, Inc. Threshold ligand-receptor assay
US5939272A (en) 1989-01-10 1999-08-17 Biosite Diagnostics Incorporated Non-competitive threshold ligand-receptor assays
US5698671A (en) * 1989-03-21 1997-12-16 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Metalloproteinase peptides
US5413923A (en) 1989-07-25 1995-05-09 Cell Genesys, Inc. Homologous recombination for universal donor cells and chimeric mammalian hosts
US5859205A (en) 1989-12-21 1999-01-12 Celltech Limited Humanised antibodies
EP1690934A3 (en) 1990-01-12 2008-07-30 Abgenix, Inc. Generation of xenogeneic antibodies
US5922615A (en) 1990-03-12 1999-07-13 Biosite Diagnostics Incorporated Assay devices comprising a porous capture membrane in fluid-withdrawing contact with a nonabsorbent capillary network
US5166051A (en) 1990-08-08 1992-11-24 Genesis Labs, Inc. Membranes, membrane overlays for exclusion of erythrocytes, and method for immunoassay of whole blood analytes
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
ATE300615T1 (de) 1990-08-29 2005-08-15 Genpharm Int Transgene mäuse fähig zur produktion heterologer antikörper
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5814318A (en) 1990-08-29 1998-09-29 Genpharm International Inc. Transgenic non-human animals for producing heterologous antibodies
CA2072758A1 (en) 1990-09-14 1992-03-15 Kenneth Francis Buechler Antibodies to complexes of ligand receptors and ligands and their utility in ligand-receptor assays
US5955377A (en) 1991-02-11 1999-09-21 Biostar, Inc. Methods and kits for the amplification of thin film based assays
AU1772992A (en) 1991-04-10 1992-11-17 Biosite Diagnostics Incorporated Crosstalk inhibitors and their uses
JP3290988B2 (ja) 1991-04-11 2002-06-10 バイオサイト・ダイアグノスティックス・インコーポレイテッド 多重リガンドを同時検出する新規接合体及び検定法
US6797492B2 (en) 1991-05-17 2004-09-28 Merck & Co., Inc. Method for reducing the immunogenicity of antibody variable domains
WO1994004679A1 (en) 1991-06-14 1994-03-03 Genentech, Inc. Method for making humanized antibodies
EP1400536A1 (en) 1991-06-14 2004-03-24 Genentech Inc. Method for making humanized antibodies
US5885527A (en) 1992-05-21 1999-03-23 Biosite Diagnostics, Inc. Diagnostic devices and apparatus for the controlled movement of reagents without membrances
US6143576A (en) 1992-05-21 2000-11-07 Biosite Diagnostics, Inc. Non-porous diagnostic devices for the controlled movement of reagents
US5494829A (en) 1992-07-31 1996-02-27 Biostar, Inc. Devices and methods for detection of an analyte based upon light interference
US5824799A (en) 1993-09-24 1998-10-20 Biosite Diagnostics Incorporated Hybrid phthalocyanine derivatives and their uses
US6562596B1 (en) * 1993-10-06 2003-05-13 Amgen Inc. Tissue inhibitor of metalloproteinase type three (TIMP-3) composition and methods
CA2219361C (en) 1995-04-27 2012-02-28 Abgenix, Inc. Human antibodies derived from immunized xenomice
EP0823941A4 (en) 1995-04-28 2001-09-19 Abgenix Inc HUMAN ANTIBODIES DERIVED FROM IMMUNIZED XENO MOUSES
US6391265B1 (en) 1996-08-26 2002-05-21 Biosite Diagnostics, Inc. Devices incorporating filters for filtering fluid samples
US6113855A (en) 1996-11-15 2000-09-05 Biosite Diagnostics, Inc. Devices comprising multiple capillarity inducing surfaces
EP1500329B1 (en) 1996-12-03 2012-03-21 Amgen Fremont Inc. Human antibodies that specifically bind human TNF alpha
US6045899A (en) 1996-12-12 2000-04-04 Usf Filtration & Separations Group, Inc. Highly assymetric, hydrophilic, microfiltration membranes having large pore diameters
US5947124A (en) 1997-03-11 1999-09-07 Biosite Diagnostics Incorporated Diagnostic for determining the time of a heart attack
US6057098A (en) 1997-04-04 2000-05-02 Biosite Diagnostics, Inc. Polyvalent display libraries
DE69840657D1 (de) * 1997-07-16 2009-04-23 Charm Sciences Inc Verfahren zum Nachweis eines Restanalyts in einer Probe
EP1064553A4 (en) * 1998-03-16 2001-09-12 Quidel Corp DEVICE AND METHOD FOR IMMUNOASSAY
US7214542B2 (en) * 2003-01-30 2007-05-08 Michael Hutchinson Method of processing assay test results
WO2004096832A2 (en) * 2003-04-29 2004-11-11 Children's Medical Center Corporation Novel antiangiogenic peptides
EP1662257A4 (en) * 2003-08-11 2007-12-12 Kyowa Medex Co Ltd TOOL FOR MEASURING MEASURING OBJECT, MEASURING DEVICE AND MEASURING METHOD
WO2006010529A1 (en) * 2004-07-28 2006-02-02 F. Hoffmann-La Roche Ag Timp-2 as target/marker of beta cell failure
US7485468B2 (en) * 2004-10-15 2009-02-03 Galapagos Bv Molecular targets and compounds, and methods to identify the same, useful in the treatment of joint degenerative and inflammatory diseases
WO2007048102A2 (en) * 2005-10-18 2007-04-26 The Government Of The United States, As Represented By The Secretary Of Health And Human Services Angio-inhibitory peptides derived from human timp-2
ES2836218T3 (es) 2008-10-21 2021-06-24 Astute Medical Inc Procedimientos y composiciones para el diagnóstico y pronóstico de lesión renal e insuficiencia renal
US8900881B2 (en) * 2008-12-30 2014-12-02 Jin Po Lee Quantitative analyte assay device and method
WO2011075744A1 (en) 2009-12-20 2011-06-23 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
JP5914326B2 (ja) * 2010-03-31 2016-05-11 積水メディカル株式会社 イムノクロマトグラフィーを利用した測定方法、イムノクロマトグラフィー用テストストリップ及びイムノクロマトグラフィー用測定試薬キット

Also Published As

Publication number Publication date
CN105531291A (zh) 2016-04-27
MX2016001573A (es) 2016-09-07
US10457744B2 (en) 2019-10-29
JP2016528236A (ja) 2016-09-15
EA201690185A1 (ru) 2016-07-29
US20160297893A1 (en) 2016-10-13
HK1222180A1 (zh) 2017-06-23
EP3030582A4 (en) 2017-05-17
WO2015021308A1 (en) 2015-02-12
EP3030582A1 (en) 2016-06-15
US20180162953A1 (en) 2018-06-14
CA2920521A1 (en) 2015-02-12
US9879091B2 (en) 2018-01-30
EP3617234A1 (en) 2020-03-04
AU2014305883A1 (en) 2016-02-25
KR20160039682A (ko) 2016-04-11

Similar Documents

Publication Publication Date Title
BR112016002685A2 (pt) ensaios para timp2 que apresentam melhor desempenho em amostras biológicas
BR112016010106A2 (pt) ensaios para igfbp7 com melhor desempenho em amostras biológicas
MX374652B (es) Ensayos para detectar la presencia o la cantidad de un anticuerpo antifármaco.
MX362075B (es) Ensayo de combinación de antígeno-anticuerpo del virus de la hepatitis c (vhc) y métodos y composiciones para usarlo.
BR112014025384A8 (pt) método e sistema para executar ensaio automatizado e métodos para executar teste reflexivo em vários exemplares
BR112016019836A2 (pt) método para analisar uma amostra de um sujeito, dispositivo de diagnóstico para utilização no diagnóstico da endometriose, kit, uso de um biomarcador, e, método para aumentar uma resposta de anticorpos em um sujeito
MX377956B (es) Sistemas y métodos para maximización de uso de muestras.
BR112014008382A2 (pt) anticorpo especificamente ligando a epítope no domínio sema do c-met
AR093984A1 (es) Anticuerpos que se unen a ligando 1 de muerte programada (pd-l1) humano
MX2017003454A (es) Sistemas y metodos para la integracion de la recoleccion de microfluido lagrimal y el analisis por flujo lateral de analitos de interes.
BR112014018970A8 (pt) Dispositivos de coleta de amostra com agentes de estabilização sanguínea
MX2020003523A (es) Deteccion de dimetilarginina simetrica.
BR112015026242A2 (pt) dispositivo de coleta de fluido biológico e sistema de separação e testagem de fluido biológico
CL2013000813A1 (es) Dispositivo inmunocromatográfico que comprende una membrana que tiene un anticuerpo capaz de unirse a una proteina z-aat presente en una muestra de un portador del gen piz; metodo para determinar un portador del gen piz; metodo para diagnosticar una afección o enfermedad asociada con la deficiencia de aat; kits de inmunocromatografia
MX2016013255A (es) Metodos y composiciones para detectar proteinas mal plegadas.
BRPI0814343A2 (pt) Materiais e métodos para a seleção da sexagem do esperma
BR112013024686B8 (pt) Ensaio de psa, e, reagente de ensaio de psa
PE20160657A1 (es) Composiciones y metodos para identificar un riesgo de cancer en un sujeto
BR112014031958A2 (pt) bag3 como marcador de tecido e soro bioquímico
EP2599865A4 (en) MONOCLONAL ANTI-FDP ANTIBODY, FDP MEASURING REAGENT AND REAGENT KIT THEREFOR, AND FDP MEASUREMENT PROCEDURES
MX2019000591A (es) Tira mejorada de ensayo de analisis de orina de bajo volumen de muestra, kits analiticos y metodos de uso relacionados con la misma.
BR112017017719A2 (pt) imunoensaio homogêneo com compensação para sinal antecedente
WO2014151290A3 (en) Assay for predictive biomarkers
BR112016003058A2 (pt) composições e métodos para análise multiplex de ácidos nucleicos nras e braf
EA201400571A1 (ru) Специфичные к трансресвератролу антитела и их применение

Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NAO 10196/2001, QUE MODIFICOU A LEI NAO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUAANCIA PRA VIA DA ANVISA. CONSIDERANDO A APROVAA AO DOS TERMOS DO PARECER NAO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NAO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDAANCIAS CABA-VEIS.

B07G Grant request does not fulfill article 229-c lpi (prior consent of anvisa)
B06U Preliminary requirement: requests with searches performed by other patent offices: suspension of the patent application procedure
B08F Application fees: dismissal - article 86 of industrial property law

Free format text: REFERENTE A 6A ANUIDADE.

B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements