BR112015030355A8 - uso de uma proteína ou um polipeptídeo de adenilil ciclase tipo 6 (ac6) incompetente com a adenosina monofosfato cíclico (incompetente com camp) ou um gene ou ácido nucléico que codifica ac6mut, e, formulação - Google Patents
uso de uma proteína ou um polipeptídeo de adenilil ciclase tipo 6 (ac6) incompetente com a adenosina monofosfato cíclico (incompetente com camp) ou um gene ou ácido nucléico que codifica ac6mut, e, formulação Download PDFInfo
- Publication number
- BR112015030355A8 BR112015030355A8 BR112015030355A BR112015030355A BR112015030355A8 BR 112015030355 A8 BR112015030355 A8 BR 112015030355A8 BR 112015030355 A BR112015030355 A BR 112015030355A BR 112015030355 A BR112015030355 A BR 112015030355A BR 112015030355 A8 BR112015030355 A8 BR 112015030355A8
- Authority
- BR
- Brazil
- Prior art keywords
- incompetent
- camp
- ac6mut
- polypeptide
- gene
- Prior art date
Links
- 108090000623 proteins and genes Proteins 0.000 title abstract 4
- 102000030621 adenylate cyclase Human genes 0.000 title abstract 3
- 108060000200 adenylate cyclase Proteins 0.000 title abstract 3
- 238000009472 formulation Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 108020004707 nucleic acids Proteins 0.000 title abstract 2
- 102000039446 nucleic acids Human genes 0.000 title abstract 2
- 150000007523 nucleic acids Chemical class 0.000 title abstract 2
- 229920001184 polypeptide Polymers 0.000 title abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
- 102000004169 proteins and genes Human genes 0.000 title abstract 2
- IVOMOUWHDPKRLL-KQYNXXCUSA-N Cyclic adenosine monophosphate Chemical compound C([C@H]1O2)OP(O)(=O)O[C@H]1[C@@H](O)[C@@H]2N1C(N=CN=C2N)=C2N=C1 IVOMOUWHDPKRLL-KQYNXXCUSA-N 0.000 title 1
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 abstract 2
- 208000019622 heart disease Diseases 0.000 abstract 2
- 239000002126 C01EB10 - Adenosine Substances 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- UDMBCSSLTHHNCD-UHFFFAOYSA-N Coenzym Q(11) Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(O)=O)C(O)C1O UDMBCSSLTHHNCD-UHFFFAOYSA-N 0.000 abstract 1
- 206010019280 Heart failures Diseases 0.000 abstract 1
- 229960005305 adenosine Drugs 0.000 abstract 1
- UDMBCSSLTHHNCD-KQYNXXCUSA-N adenosine 5'-monophosphate Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O UDMBCSSLTHHNCD-KQYNXXCUSA-N 0.000 abstract 1
- LNQVTSROQXJCDD-UHFFFAOYSA-N adenosine monophosphate Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(CO)C(OP(O)(O)=O)C1O LNQVTSROQXJCDD-UHFFFAOYSA-N 0.000 abstract 1
- 230000004217 heart function Effects 0.000 abstract 1
- 230000001771 impaired effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000007170 pathology Effects 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 230000002103 transcriptional effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/51—Lyases (4)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y406/00—Phosphorus-oxygen lyases (4.6)
- C12Y406/01—Phosphorus-oxygen lyases (4.6.1)
- C12Y406/01001—Aodenylate cyclase (4.6.1.1)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Hospice & Palliative Care (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Virology (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361832759P | 2013-06-07 | 2013-06-07 | |
| PCT/US2014/040948 WO2014197624A1 (en) | 2013-06-07 | 2014-06-04 | Cycle adenosine monophosphate-incompetent adenylyl cyclase and compositions and methods for treating heart failure and increasing cardiac function |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112015030355A2 BR112015030355A2 (pt) | 2017-07-25 |
| BR112015030355A8 true BR112015030355A8 (pt) | 2019-12-24 |
Family
ID=52008569
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112015030355A BR112015030355A8 (pt) | 2013-06-07 | 2014-06-04 | uso de uma proteína ou um polipeptídeo de adenilil ciclase tipo 6 (ac6) incompetente com a adenosina monofosfato cíclico (incompetente com camp) ou um gene ou ácido nucléico que codifica ac6mut, e, formulação |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US11040091B2 (https=) |
| EP (1) | EP3004343B1 (https=) |
| JP (1) | JP6571069B2 (https=) |
| KR (1) | KR20160032090A (https=) |
| CN (1) | CN105452458A (https=) |
| AU (1) | AU2014274902B2 (https=) |
| BR (1) | BR112015030355A8 (https=) |
| CA (1) | CA2914029A1 (https=) |
| DK (1) | DK3004343T3 (https=) |
| HK (1) | HK1222884A1 (https=) |
| IL (1) | IL242885B (https=) |
| RU (1) | RU2015155831A (https=) |
| WO (1) | WO2014197624A1 (https=) |
| ZA (1) | ZA201508942B (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107635584B (zh) * | 2015-04-09 | 2022-06-17 | 康奈尔大学 | 基因治疗以预防对过敏原的反应 |
| CN109890400B (zh) * | 2016-10-24 | 2022-12-20 | 贝特基因公司 | 包含蛋白磷酸酶1抑制肽的血管疾病治疗用组合物 |
| WO2018090036A1 (en) * | 2016-11-14 | 2018-05-17 | Renova Therapeutics, Inc. | Method of protection for cardiac tissue |
| US11760987B2 (en) | 2017-09-07 | 2023-09-19 | The Regents Of The University Of California | Compositions and methods for the treatment or prevention of heart failure |
| EP3689363A4 (en) * | 2017-09-29 | 2021-05-19 | BethphaGen Inc. | PHARMACEUTICAL COMPOSITION FOR THE PREVENTION OR TREATMENT OF CARDIAC ARRHYTHMIA |
| CA3100280A1 (en) * | 2018-06-08 | 2019-12-12 | University Of Florida Research Foundation, Incorporated | Aav cardiac gene therapy for cardiomyopathy |
| CN109010799B (zh) * | 2018-07-09 | 2021-07-06 | 沣潮医药科技（上海）有限公司 | RyR2蛋白或RyR2重组蛋白在制备抗心力衰竭药物中的用途 |
| CN109191052B (zh) * | 2018-10-22 | 2020-09-25 | 山东大学 | 一种多车型车辆路径优化方法、服务器及系统 |
| JP2023535632A (ja) | 2020-07-27 | 2023-08-18 | アンジャリウム バイオサイエンシズ エージー | Ｄｎａ分子の組成物、その作製方法、及びその使用方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1255822A2 (en) * | 1999-12-27 | 2002-11-13 | The Regents Of The University Of California | Modified adenylylcyclase type vi useful in gene therapy for congestive heart failure |
-
2014
- 2014-06-04 EP EP14808138.3A patent/EP3004343B1/en active Active
- 2014-06-04 DK DK14808138.3T patent/DK3004343T3/en active
- 2014-06-04 CA CA2914029A patent/CA2914029A1/en not_active Abandoned
- 2014-06-04 BR BR112015030355A patent/BR112015030355A8/pt not_active Application Discontinuation
- 2014-06-04 JP JP2016517971A patent/JP6571069B2/ja active Active
- 2014-06-04 WO PCT/US2014/040948 patent/WO2014197624A1/en not_active Ceased
- 2014-06-04 AU AU2014274902A patent/AU2014274902B2/en active Active
- 2014-06-04 CN CN201480044190.5A patent/CN105452458A/zh active Pending
- 2014-06-04 US US14/893,905 patent/US11040091B2/en active Active
- 2014-06-04 KR KR1020167000315A patent/KR20160032090A/ko not_active Ceased
- 2014-06-04 RU RU2015155831A patent/RU2015155831A/ru not_active Application Discontinuation
- 2014-06-04 HK HK16111093.5A patent/HK1222884A1/zh unknown
-
2015
- 2015-12-02 IL IL242885A patent/IL242885B/en active IP Right Grant
- 2015-12-08 ZA ZA2015/08942A patent/ZA201508942B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2014274902B2 (en) | 2020-06-04 |
| BR112015030355A2 (pt) | 2017-07-25 |
| RU2015155831A3 (https=) | 2018-03-28 |
| JP6571069B2 (ja) | 2019-09-04 |
| US11040091B2 (en) | 2021-06-22 |
| WO2014197624A1 (en) | 2014-12-11 |
| EP3004343A1 (en) | 2016-04-13 |
| IL242885B (en) | 2019-12-31 |
| JP2016521708A (ja) | 2016-07-25 |
| US20160101164A1 (en) | 2016-04-14 |
| RU2015155831A (ru) | 2017-07-14 |
| HK1222884A1 (zh) | 2017-07-14 |
| DK3004343T3 (en) | 2019-02-04 |
| CN105452458A (zh) | 2016-03-30 |
| AU2014274902A1 (en) | 2015-12-24 |
| KR20160032090A (ko) | 2016-03-23 |
| EP3004343B1 (en) | 2018-10-10 |
| EP3004343A4 (en) | 2017-01-04 |
| CA2914029A1 (en) | 2014-12-11 |
| ZA201508942B (en) | 2019-05-29 |
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Legal Events
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| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
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| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements | ||
| B350 | Update of information on the portal [chapter 15.35 patent gazette] |