BR112014023572A2 - método para tratar ou prevenir dano de articulação em um indivíduo com ra precoce ou ra incipiente, uso de um agente ou combinação de agentes que estimulam uma resposta tolerogênica específica de antígeno a um polipeptídeo de agrecan, e agente ou combinação de agentes - Google Patents
método para tratar ou prevenir dano de articulação em um indivíduo com ra precoce ou ra incipiente, uso de um agente ou combinação de agentes que estimulam uma resposta tolerogênica específica de antígeno a um polipeptídeo de agrecan, e agente ou combinação de agentesInfo
- Publication number
- BR112014023572A2 BR112014023572A2 BR112014023572A BR112014023572A BR112014023572A2 BR 112014023572 A2 BR112014023572 A2 BR 112014023572A2 BR 112014023572 A BR112014023572 A BR 112014023572A BR 112014023572 A BR112014023572 A BR 112014023572A BR 112014023572 A2 BR112014023572 A2 BR 112014023572A2
- Authority
- BR
- Brazil
- Prior art keywords
- agents
- agent
- combination
- joint damage
- incipient
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/075—Ethers or acetals
- A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
- A61K31/09—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon having two or more such linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
método para tratar ou prevenir dano em articulação em um indivíduo com ra precoce ou ra incipiente, uso de um agente ou combinação de agentes que estimulam uma resposta tolerogênica específica de antígeno a um polipeptídeo de agrecan, e agente ou combinação de agentes são descritos agentes imunomoduladores que são utilizáveis no tratamento ou prevenção de dano nas articulações. mais particularmente, são descritos imunomoduladores para uso no estímulo de uma resposta toleogênica específica de antígeno para um peptídeo de agrecan, incluindo formas citrulinadas dos mesmos para tratar ou prevenir dano nas articulações, incluindo dano nas articulações de indivíduos com ra precoce ou ra incipiente.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2012901189A AU2012901189A0 (en) | 2012-03-23 | Immunomodulatory agents and uses therefor | |
PCT/AU2013/000303 WO2013138871A1 (en) | 2012-03-23 | 2013-03-25 | Immunomodulatory agent and uses therefor |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112014023572A2 true BR112014023572A2 (pt) | 2017-09-12 |
Family
ID=49221713
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112014023572A BR112014023572A2 (pt) | 2012-03-23 | 2013-03-25 | método para tratar ou prevenir dano de articulação em um indivíduo com ra precoce ou ra incipiente, uso de um agente ou combinação de agentes que estimulam uma resposta tolerogênica específica de antígeno a um polipeptídeo de agrecan, e agente ou combinação de agentes |
Country Status (17)
Country | Link |
---|---|
US (1) | US20150216955A1 (pt) |
EP (1) | EP2827890B1 (pt) |
JP (2) | JP2015512371A (pt) |
KR (1) | KR20150010716A (pt) |
CN (2) | CN104519907A (pt) |
AU (1) | AU2013234815B2 (pt) |
BR (1) | BR112014023572A2 (pt) |
CA (1) | CA2868123A1 (pt) |
CL (1) | CL2014002522A1 (pt) |
EA (1) | EA201491748A1 (pt) |
IL (1) | IL234756A0 (pt) |
MX (1) | MX2014011488A (pt) |
MY (1) | MY172706A (pt) |
NZ (1) | NZ631340A (pt) |
PH (1) | PH12014502063A1 (pt) |
SG (2) | SG11201405848UA (pt) |
WO (1) | WO2013138871A1 (pt) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2012082803A2 (en) | 2010-12-13 | 2012-06-21 | Cel-Sci Corporation | Method for inducing an immune response against avian, swine, spanish, h1n1, h5n9 influenza viruses and formulations thereof |
WO2012162564A1 (en) | 2011-05-25 | 2012-11-29 | Cel-Sci Corporation | Method for inducing an immune response and formulations thereof |
WO2012162565A2 (en) | 2011-05-25 | 2012-11-29 | Cel-Sci Corporation | Method for inducing an immune response for treatment of cancer and autoimmune diseases or conditions |
CN109771444A (zh) * | 2019-04-03 | 2019-05-21 | 哈尔滨北极神生物工程有限公司 | 蜂胶氨糖人参皂甙复合胶囊及制备方法 |
US20220218806A1 (en) * | 2019-05-11 | 2022-07-14 | CRL-SCI Corporation | Peptides and conjugates for treatment of arthritis |
EP4100034A1 (en) * | 2020-02-06 | 2022-12-14 | Unigen, Inc. | Compositions comprising extracts of aplinia and other plants for improving joint health and treating arthritis |
CN112675299B (zh) * | 2021-01-06 | 2023-10-20 | 黑龙江省百洲生物工程有限公司 | 一种防控鹅星状病毒复合佐剂灭活疫苗的制备方法 |
WO2024057793A1 (ja) * | 2022-09-13 | 2024-03-21 | 国立大学法人信州大学 | 癌転移を抑制するシトルリン化ペプチド |
CN117085118A (zh) * | 2023-08-22 | 2023-11-21 | 北京大学人民医院 | 一种瓜氨酸化ii型胶原多肽疫苗及其应用 |
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EP0420913B1 (en) | 1988-06-14 | 1995-11-15 | Cell Med, Inc. | Heterofunctional cellular immunological reagents, vaccines containing same and methods for the use of same |
US6106840A (en) | 1988-06-23 | 2000-08-22 | Anergen, Inc. | MHC conjugates useful in ameliorating autoimmunity |
FI87028C (fi) | 1989-12-22 | 1992-11-10 | Nokia Mobile Phones Ltd | Metod foer att reglera effekt hos en spaenningsstyrd effektfoerstaerkare och koppling foer anvaendning i metoden |
US5139749A (en) | 1990-06-22 | 1992-08-18 | Tas, Inc. | Fluidized calcining process |
PT98990A (pt) | 1990-09-19 | 1992-08-31 | American Home Prod | Processo para a preparacao de esteres de acidos carboxilicos de rapamicina |
ZA935112B (en) | 1992-07-17 | 1994-02-08 | Smithkline Beecham Corp | Rapamycin derivatives |
US5234140A (en) | 1992-07-28 | 1993-08-10 | S. C. Johnson & Son, Inc. | Re-useable aerosol container |
US5817308A (en) | 1994-02-14 | 1998-10-06 | University Of Rochester | Tolerogenic fusion proteins of immunoglobulins and methods for inducing and maintaining tolerance |
IL129547A (en) | 1994-10-26 | 2001-01-11 | Novartis Ag | Pharmaceutical compositions comprising a macrolide and an acid |
AU740222C (en) | 1996-03-20 | 2002-10-10 | Genzyme Corporation | A method for identifying cytotoxic T-cell epitopes |
GB9612629D0 (en) | 1996-06-17 | 1996-08-21 | Oxford Biosciences Ltd | Method for providing dense particle compositions for use in transdermal particle delivery |
EP0937082A2 (en) | 1996-07-12 | 1999-08-25 | Ariad Pharmaceuticals, Inc. | Materials and method for treating or preventing pathogenic fungal infection |
EP1054004B1 (en) | 1997-12-15 | 2008-07-16 | Astellas Pharma Inc. | Novel pyrimidine-5-carboxamide derivatives |
AU783158B2 (en) | 1999-08-24 | 2005-09-29 | Ariad Pharmaceuticals, Inc. | 28-epirapalogs |
BR0109455A (pt) * | 2000-03-23 | 2003-06-03 | Akzo Nobel Nv | Uso de mia e/ou seus fragmentos, método para tratar mamìferos sofrendo de, ou susceptìvel a, uma doença inflamatória, peptìdeo, composição farmacêutica, e, uso dos peptìdeos |
TWI329105B (en) | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
CN100522967C (zh) | 2002-02-01 | 2009-08-05 | 阿里亚德基因治疗公司 | 含磷化合物及其应用 |
US20030235610A1 (en) * | 2002-06-21 | 2003-12-25 | Piedmont Pharmaceuticals, Llc | Liposomes containing biologically active compounds |
CA2421321A1 (en) * | 2003-03-07 | 2004-09-07 | London Health Sciences Centre Research Inc. | Peptides associated with hla-dr mhc class ii molecule and involved in rheumatoid arthritis |
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JP2010505883A (ja) * | 2006-10-12 | 2010-02-25 | ザ ユニバーシティー オブ クイーンズランド | 免疫応答を調節するための組成物および方法 |
US11041013B2 (en) | 2008-03-14 | 2021-06-22 | Cel-Sci Corporation | Methods of preparation and composition of peptide constructs useful for treatment of rheumatoid arthritis |
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EP2989121B1 (en) * | 2013-04-26 | 2020-10-07 | Cel-Sci Corporation | Methods of preparation and composition of peptide constructs useful for treatment of rheumatoid arthritis |
-
2013
- 2013-03-25 SG SG11201405848UA patent/SG11201405848UA/en unknown
- 2013-03-25 MY MYPI2014702673A patent/MY172706A/en unknown
- 2013-03-25 US US14/387,529 patent/US20150216955A1/en not_active Abandoned
- 2013-03-25 CN CN201380027092.6A patent/CN104519907A/zh active Pending
- 2013-03-25 CN CN201910675625.0A patent/CN110404062A/zh active Pending
- 2013-03-25 WO PCT/AU2013/000303 patent/WO2013138871A1/en active Application Filing
- 2013-03-25 EP EP13764426.6A patent/EP2827890B1/en active Active
- 2013-03-25 EA EA201491748A patent/EA201491748A1/ru unknown
- 2013-03-25 NZ NZ631340A patent/NZ631340A/en not_active IP Right Cessation
- 2013-03-25 BR BR112014023572A patent/BR112014023572A2/pt not_active IP Right Cessation
- 2013-03-25 AU AU2013234815A patent/AU2013234815B2/en not_active Ceased
- 2013-03-25 MX MX2014011488A patent/MX2014011488A/es unknown
- 2013-03-25 CA CA2868123A patent/CA2868123A1/en not_active Abandoned
- 2013-03-25 SG SG10201706208SA patent/SG10201706208SA/en unknown
- 2013-03-25 KR KR1020147029837A patent/KR20150010716A/ko not_active Application Discontinuation
- 2013-03-25 JP JP2015500718A patent/JP2015512371A/ja active Pending
-
2014
- 2014-09-17 PH PH12014502063A patent/PH12014502063A1/en unknown
- 2014-09-21 IL IL234756A patent/IL234756A0/en unknown
- 2014-09-23 CL CL2014002522A patent/CL2014002522A1/es unknown
-
2019
- 2019-01-17 JP JP2019006439A patent/JP2019070034A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
US20150216955A1 (en) | 2015-08-06 |
CN110404062A (zh) | 2019-11-05 |
MY172706A (en) | 2019-12-11 |
SG11201405848UA (en) | 2014-10-30 |
NZ631340A (en) | 2016-11-25 |
CL2014002522A1 (es) | 2015-06-12 |
JP2019070034A (ja) | 2019-05-09 |
AU2013234815A1 (en) | 2014-10-09 |
CA2868123A1 (en) | 2013-09-26 |
EP2827890A1 (en) | 2015-01-28 |
MX2014011488A (es) | 2015-05-11 |
EP2827890A4 (en) | 2015-11-25 |
KR20150010716A (ko) | 2015-01-28 |
SG10201706208SA (en) | 2017-08-30 |
JP2015512371A (ja) | 2015-04-27 |
IL234756A0 (en) | 2014-11-30 |
AU2013234815B2 (en) | 2017-06-22 |
WO2013138871A1 (en) | 2013-09-26 |
EP2827890B1 (en) | 2019-08-28 |
CN104519907A (zh) | 2015-04-15 |
EA201491748A1 (ru) | 2015-02-27 |
PH12014502063A1 (en) | 2014-12-10 |
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