BR112015029386B1 - Uso de eribulina e lenvatinibe como terapia de combinação e kit - Google Patents
Uso de eribulina e lenvatinibe como terapia de combinação e kit Download PDFInfo
- Publication number
- BR112015029386B1 BR112015029386B1 BR112015029386-7A BR112015029386A BR112015029386B1 BR 112015029386 B1 BR112015029386 B1 BR 112015029386B1 BR 112015029386 A BR112015029386 A BR 112015029386A BR 112015029386 B1 BR112015029386 B1 BR 112015029386B1
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- BR
- Brazil
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- eribulin
- cancer
- lenvatinib
- Prior art date
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Classifications
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- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
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- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
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- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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| MY162940A (en) | 2009-08-19 | 2017-07-31 | Eisai R&D Man Co Ltd | Quinoline derivative-containing pharmaceutical composition |
| JP6038128B2 (ja) | 2011-06-03 | 2016-12-07 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | レンバチニブ化合物に対する甲状腺癌対象及び腎臓癌対象の反応性を予測及び評価するためのバイオマーカー |
| PT3524595T (pt) | 2014-08-28 | 2022-09-19 | Eisai R&D Man Co Ltd | Derivado de quinolina altamente puro e método para produção do mesmo |
| LT3263106T (lt) | 2015-02-25 | 2024-01-10 | Eisai R&D Management Co., Ltd. | Chinolino darinių kartumo sumažinimo būdas |
| KR102662228B1 (ko) | 2015-03-04 | 2024-05-02 | 머크 샤프 앤드 돔 코포레이션 | 암을 치료하기 위한 pd-1 길항제 및 vegfr/fgfr/ret 티로신 키나제 억제제의 조합 |
| AU2016226157B2 (en) * | 2015-03-04 | 2022-01-27 | Eisai R&D Management Co., Ltd. | Combination of a PD-1 antagonist and eribulin for treating cancer |
| MX373231B (es) | 2015-06-16 | 2020-05-08 | Eisai R&D Man Co Ltd | Agente anticancerigeno. |
| US12220398B2 (en) | 2015-08-20 | 2025-02-11 | Eisai R&D Management Co., Ltd. | Tumor therapeutic agent |
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| CN105832732A (zh) * | 2016-05-30 | 2016-08-10 | 青岛云天生物技术有限公司 | 一种用于胃癌治疗的药物组合物及其应用 |
| US10865212B2 (en) | 2017-01-02 | 2020-12-15 | Yonsung Fine Chemical Co.. Ltd. | Intermediate for preparing eribulin mesylate and process for preparing the same |
| US12303505B2 (en) * | 2017-02-08 | 2025-05-20 | Eisai R&D Management Co., Ltd. | Tumor-treating pharmaceutical composition |
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| WO2019097073A1 (en) | 2017-11-20 | 2019-05-23 | Basilea Pharmaceutica International AG | Pharmaceutical combinations for use in the treatment of neoplastic diseases |
| CN107973804B (zh) * | 2017-11-29 | 2020-07-03 | 戊言医药科技（上海）有限公司 | 艾瑞布林中间体的合成方法 |
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| JP6644479B2 (ja) | 2014-06-24 | 2020-02-12 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | がん治療のための併用療法としてのエリブリンとｓ−１（もしくは５−ｆｕ）の使用 |
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- 2014-06-26 JP JP2015562231A patent/JP6404242B2/ja active Active
- 2014-06-26 EP EP14739971.1A patent/EP3013335B1/en active Active
- 2014-06-26 CN CN201480036218.0A patent/CN105338977B/zh active Active
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| JP2016528162A (ja) | 2016-09-15 |
| US9549922B2 (en) | 2017-01-24 |
| CA2915005C (en) | 2021-12-28 |
| AU2014299699A1 (en) | 2015-12-10 |
| JP6404242B2 (ja) | 2018-10-10 |
| EP3013335A1 (en) | 2016-05-04 |
| KR20160023816A (ko) | 2016-03-03 |
| EP3013335B1 (en) | 2018-11-07 |
| CA2915005A1 (en) | 2014-12-31 |
| WO2014208774A1 (en) | 2014-12-31 |
| RU2016102158A (ru) | 2017-07-31 |
| BR112015029386A8 (pt) | 2020-03-17 |
| RU2672585C2 (ru) | 2018-11-16 |
| US20150005343A1 (en) | 2015-01-01 |
| ES2705698T3 (es) | 2019-03-26 |
| IL242386B (en) | 2019-06-30 |
| BR112015029386A2 (pt) | 2017-07-25 |
| AU2014299699B2 (en) | 2019-10-10 |
| CN105338977A (zh) | 2016-02-17 |
| KR102265952B1 (ko) | 2021-06-16 |
| CN105338977B (zh) | 2018-10-16 |
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