CN105338977B - 艾日布林和乐伐替尼作为治疗癌症的联合疗法的用途 - Google Patents

艾日布林和乐伐替尼作为治疗癌症的联合疗法的用途 Download PDF

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CN105338977B
CN105338977B CN201480036218.0A CN201480036218A CN105338977B CN 105338977 B CN105338977 B CN 105338977B CN 201480036218 A CN201480036218 A CN 201480036218A CN 105338977 B CN105338977 B CN 105338977B
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cancer
pharmaceutically acceptable
acceptable salt
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eribulin
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CN105338977A (zh
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野本研
野本研一
吴佳怡
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Sanitary Material R&d Management Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Dermatology (AREA)
CN201480036218.0A 2013-06-26 2014-06-26 艾日布林和乐伐替尼作为治疗癌症的联合疗法的用途 Active CN105338977B (zh)

Applications Claiming Priority (3)

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US201361839542P 2013-06-26 2013-06-26
US61/839542 2013-06-26
PCT/JP2014/067723 WO2014208774A1 (en) 2013-06-26 2014-06-26 Use of eribulin and lenvatinib as combination therapy for treatment of cancer

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CN105338977A CN105338977A (zh) 2016-02-17
CN105338977B true CN105338977B (zh) 2018-10-16

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US (1) US9549922B2 (https=)
EP (1) EP3013335B1 (https=)
JP (1) JP6404242B2 (https=)
KR (1) KR102265952B1 (https=)
CN (1) CN105338977B (https=)
AU (1) AU2014299699B2 (https=)
BR (1) BR112015029386B1 (https=)
CA (1) CA2915005C (https=)
ES (1) ES2705698T3 (https=)
IL (1) IL242386B (https=)
RU (1) RU2672585C2 (https=)
WO (1) WO2014208774A1 (https=)

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CN109793736A (zh) * 2019-01-31 2019-05-24 徐州医科大学 一种乐伐替尼在制备自然杀伤细胞激动剂中的应用
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CN114028394A (zh) * 2021-05-21 2022-02-11 中山大学 低剂量仑伐替尼在制备治疗肝癌的药物中的用途
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Also Published As

Publication number Publication date
JP2016528162A (ja) 2016-09-15
US9549922B2 (en) 2017-01-24
CA2915005C (en) 2021-12-28
AU2014299699A1 (en) 2015-12-10
JP6404242B2 (ja) 2018-10-10
EP3013335A1 (en) 2016-05-04
KR20160023816A (ko) 2016-03-03
EP3013335B1 (en) 2018-11-07
CA2915005A1 (en) 2014-12-31
WO2014208774A1 (en) 2014-12-31
RU2016102158A (ru) 2017-07-31
BR112015029386A8 (pt) 2020-03-17
RU2672585C2 (ru) 2018-11-16
US20150005343A1 (en) 2015-01-01
ES2705698T3 (es) 2019-03-26
IL242386B (en) 2019-06-30
BR112015029386A2 (pt) 2017-07-25
BR112015029386B1 (pt) 2023-11-14
AU2014299699B2 (en) 2019-10-10
CN105338977A (zh) 2016-02-17
KR102265952B1 (ko) 2021-06-16

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