BR112015028764A2 - derivados de nucleosídeo substituído 4'-fluoro-2'-metil - Google Patents

derivados de nucleosídeo substituído 4'-fluoro-2'-metil

Info

Publication number
BR112015028764A2
BR112015028764A2 BR112015028764A BR112015028764A BR112015028764A2 BR 112015028764 A2 BR112015028764 A2 BR 112015028764A2 BR 112015028764 A BR112015028764 A BR 112015028764A BR 112015028764 A BR112015028764 A BR 112015028764A BR 112015028764 A2 BR112015028764 A2 BR 112015028764A2
Authority
BR
Brazil
Prior art keywords
fluoro
methyl substituted
substituted nucleoside
nucleoside derivatives
derivatives
Prior art date
Application number
BR112015028764A
Other languages
English (en)
Other versions
BR112015028764B1 (pt
Inventor
G Klumpp Klaus
Smith Mark
Original Assignee
Riboscience Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Riboscience Llc filed Critical Riboscience Llc
Publication of BR112015028764A2 publication Critical patent/BR112015028764A2/pt
Publication of BR112015028764B1 publication Critical patent/BR112015028764B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/11—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids containing cyclic phosphate

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analyzing Materials Using Thermal Means (AREA)
BR112015028764-6A 2013-05-16 2014-05-15 Derivados de nucleosídeo de 4-fluoro-2-metil substituídos como inibidores de replicação de rna do hcv BR112015028764B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361824030P 2013-05-16 2013-05-16
US61/824,030 2013-05-16
PCT/US2014/038287 WO2014186637A1 (en) 2013-05-16 2014-05-15 4'-fluor0-2'-methyl substituted nucleoside derivatives

Publications (2)

Publication Number Publication Date
BR112015028764A2 true BR112015028764A2 (pt) 2017-07-25
BR112015028764B1 BR112015028764B1 (pt) 2022-09-27

Family

ID=51895938

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015028764-6A BR112015028764B1 (pt) 2013-05-16 2014-05-15 Derivados de nucleosídeo de 4-fluoro-2-metil substituídos como inibidores de replicação de rna do hcv

Country Status (23)

Country Link
US (1) US9895442B2 (pt)
EP (1) EP2996695B1 (pt)
JP (1) JP6366693B2 (pt)
KR (1) KR102241198B1 (pt)
CN (1) CN105307662B (pt)
AU (1) AU2014265293B2 (pt)
BR (1) BR112015028764B1 (pt)
CA (1) CA2912682C (pt)
CL (1) CL2015003357A1 (pt)
CR (1) CR20150648A (pt)
EA (1) EA035301B1 (pt)
HK (2) HK1217294A1 (pt)
IL (1) IL242605B (pt)
MA (2) MA46490A1 (pt)
MX (1) MX2015015782A (pt)
MY (1) MY186547A (pt)
NZ (1) NZ714927A (pt)
PE (1) PE20160120A1 (pt)
PH (1) PH12015502588B1 (pt)
SG (1) SG11201509424VA (pt)
UA (1) UA123533C2 (pt)
WO (1) WO2014186637A1 (pt)
ZA (1) ZA201509056B (pt)

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EA027929B1 (ru) 2012-05-25 2017-09-29 Янссен Сайенсиз Айрлэнд Юси Нуклеозиды на основе урацила и спирооксетана
SG11201504554UA (en) 2012-12-21 2015-07-30 Alios Biopharma Inc Substituted nucleosides, nucleotides and analogs thereof
US20180200280A1 (en) 2013-05-16 2018-07-19 Riboscience Llc 4'-Fluoro-2'-Methyl Substituted Nucleoside Derivatives as Inhibitors of HCV RNA Replication
SG10201804835VA (en) 2013-10-11 2018-07-30 Alios Biopharma Inc Substituted nucleosides, nucleotides and analogs thereof
EP3160979A4 (en) * 2014-06-24 2018-01-03 Alios Biopharma, Inc. Methods of preparing substituted nucleotide analogs
MA41441A (fr) * 2014-12-19 2017-12-12 Alios Biopharma Inc Nucléosides substitués, nucléotides et analogues de ceux-ci
RS62434B1 (sr) 2014-12-26 2021-11-30 Univ Emory Antivirusni n4-hidroksicitidin derivati
KR20180071276A (ko) * 2015-09-29 2018-06-27 얀센 파마슈티칼즈, 인코포레이티드 Hcv 치료를 위한 조합물 요법 투약법
WO2018017989A1 (en) * 2016-07-22 2018-01-25 Janssen Pharmaceuticals, Inc. Combination therapy regimen for treatment of selected hcv genotypes
CN108424431B (zh) * 2017-09-06 2021-04-20 上海兆维科技发展有限公司 α-尿嘧啶核苷的制备方法
AR112702A1 (es) * 2017-09-21 2019-11-27 Riboscience Llc Derivados de nucleósidos sustituidos con 4’-fluoro-2’-metilo como inhibidores de la replicación de hcv arn
CN111372592A (zh) 2017-12-07 2020-07-03 埃默里大学 N4-羟基胞苷及衍生物和与其相关的抗病毒用途
AU2019231725B2 (en) * 2018-03-07 2024-06-20 Emory University 4'-halogen containing nucleotide and nucleoside therapeutic compositions and uses related thereto
CN112142809B (zh) * 2020-09-29 2022-03-22 佛山科学技术学院 尿苷酸双丙酸酯基氨基磷酸酯化合物、其药物组合物及其制备方法和应用
WO2024086592A2 (en) * 2022-10-17 2024-04-25 Emory Unversity 4'-halogen containing nucleotide and nucleoside therapeutic compositions and uses related thereto

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Also Published As

Publication number Publication date
HK1217294A1 (zh) 2017-01-06
CN105307662B (zh) 2019-06-04
AU2014265293A1 (en) 2015-12-24
JP6366693B2 (ja) 2018-08-01
EA201592184A1 (ru) 2016-04-29
CA2912682C (en) 2021-07-06
PH12015502588A1 (en) 2016-02-29
MX2015015782A (es) 2016-06-02
EP2996695A4 (en) 2016-12-14
KR102241198B1 (ko) 2021-04-15
WO2014186637A1 (en) 2014-11-20
CR20150648A (es) 2016-03-09
IL242605B (en) 2018-08-30
UA123533C2 (uk) 2021-04-21
BR112015028764B1 (pt) 2022-09-27
KR20160040141A (ko) 2016-04-12
AU2014265293B2 (en) 2019-07-18
EA035301B1 (ru) 2020-05-26
MA38675A1 (fr) 2017-12-29
NZ714927A (en) 2020-09-25
MY186547A (en) 2021-07-26
EP2996695A1 (en) 2016-03-23
US20140341847A1 (en) 2014-11-20
CA2912682A1 (en) 2014-11-20
PH12015502588B1 (en) 2016-02-29
EP2996695B1 (en) 2022-04-13
MA46490A1 (fr) 2021-04-30
CL2015003357A1 (es) 2016-11-04
JP2016518453A (ja) 2016-06-23
ZA201509056B (en) 2016-11-30
HK1219900A1 (zh) 2017-04-21
CN105307662A (zh) 2016-02-03
SG11201509424VA (en) 2015-12-30
US9895442B2 (en) 2018-02-20
PE20160120A1 (es) 2016-02-24

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B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

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