BR112015027682A2 - Uso de sobetirome no tratamento de doenças ou condições associadas com a desmielinização ou mielinização insuficiente - Google Patents
Uso de sobetirome no tratamento de doenças ou condições associadas com a desmielinização ou mielinização insuficienteInfo
- Publication number
- BR112015027682A2 BR112015027682A2 BR112015027682A BR112015027682A BR112015027682A2 BR 112015027682 A2 BR112015027682 A2 BR 112015027682A2 BR 112015027682 A BR112015027682 A BR 112015027682A BR 112015027682 A BR112015027682 A BR 112015027682A BR 112015027682 A2 BR112015027682 A2 BR 112015027682A2
- Authority
- BR
- Brazil
- Prior art keywords
- sobetirome
- demyelination
- diseases
- treatment
- conditions associated
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/40—Mineralocorticosteroids, e.g. aldosterone; Drugs increasing or potentiating the activity of mineralocorticosteroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Endocrinology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Hospice & Palliative Care (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361819467P | 2013-05-03 | 2013-05-03 | |
| PCT/US2013/053640 WO2014178892A1 (en) | 2013-05-03 | 2013-08-05 | Use of sobetirome in the treatment of x-linked adrenolenoleukodystrophy |
| PCT/US2014/014943 WO2014178931A1 (en) | 2013-05-03 | 2014-02-05 | Sobetirome in the treatment of myelination diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112015027682A2 true BR112015027682A2 (pt) | 2017-08-29 |
Family
ID=51843844
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112015027682A BR112015027682A2 (pt) | 2013-05-03 | 2014-02-05 | Uso de sobetirome no tratamento de doenças ou condições associadas com a desmielinização ou mielinização insuficiente |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US10226438B2 (enExample) |
| EP (1) | EP2991670B8 (enExample) |
| JP (4) | JP2016517883A (enExample) |
| CN (1) | CN105431163A (enExample) |
| AU (1) | AU2014260468A1 (enExample) |
| BR (1) | BR112015027682A2 (enExample) |
| CA (1) | CA2911309A1 (enExample) |
| ES (1) | ES2745532T3 (enExample) |
| MX (2) | MX379043B (enExample) |
| RU (1) | RU2015151216A (enExample) |
| SG (2) | SG11201509012QA (enExample) |
| WO (2) | WO2014178892A1 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2016517883A (ja) | 2013-05-03 | 2016-06-20 | オレゴン ヘルス アンド サイエンス ユニバーシティー | Ｘ連鎖副腎白質ジストロフィーの処置におけるソベチロムの使用 |
| JP6302091B2 (ja) | 2014-04-30 | 2018-03-28 | ザ・ジョンズ・ホプキンス・ユニバーシティー | デンドリマー組成物および眼の疾患の処置におけるその使用 |
| EP3180031A1 (en) | 2014-08-13 | 2017-06-21 | The Johns Hopkins University | Selective dendrimer delivery to brain tumors |
| CA3003589C (en) * | 2015-10-29 | 2021-12-07 | The Johns Hopkins University | Dendrimer compositions and methods for treatment of peroxisomal disorders and leukodystrophies |
| US20190134069A1 (en) * | 2016-04-22 | 2019-05-09 | Viking Therapeutics, Inc. | Use of thyroid beta-agonists |
| KR102407059B1 (ko) * | 2016-04-22 | 2022-06-10 | 바이킹 테라퓨틱스 인코포레이티드 | 갑상선 베타-작용제의 사용 |
| CN113277958A (zh) * | 2016-05-18 | 2021-08-20 | 俄勒冈健康科学大学 | 苏比替罗衍生物 |
| KR102537274B1 (ko) | 2016-08-12 | 2023-05-25 | 오레곤 헬스 앤드 사이언스 유니버시티 | 아마이드 화합물, 이의 약학 조성물 및 이들을 이용하는 방법 |
| WO2018183940A1 (en) * | 2017-03-31 | 2018-10-04 | Neurovia, Inc. | Methods and compositions for treating niemann-pick disease |
| CN110913916A (zh) | 2017-04-27 | 2020-03-24 | 约翰霍普金斯大学 | 用于血管造影的树状聚合物组合物 |
| WO2018208707A1 (en) * | 2017-05-08 | 2018-11-15 | Neurovia, Inc. | Methods and compositions for treating demyelinating diseases |
| US10780069B2 (en) * | 2017-05-18 | 2020-09-22 | University of Pittsburgh—of the Commonwealth System of Higher Education | Use of GC-1 in transplant related population |
| EP3644983B1 (en) | 2017-06-29 | 2023-10-25 | Yale University | Compositions and methods of treating or preventing fibrotic lung diseases |
| CN110891583B (zh) * | 2017-07-18 | 2023-06-06 | 学校法人庆应义塾 | 针对Th1细胞诱导性细菌的抗菌组合物 |
| CA3082121C (en) | 2017-11-10 | 2023-01-24 | The Johns Hopkins University | Dendrimer delivery system and methods of use thereof |
| JP2022513449A (ja) | 2018-12-12 | 2022-02-08 | オートバーン セラピューティクス，インク． | 新規な甲状腺模倣物 |
| EP3931180A1 (en) | 2019-03-01 | 2022-01-05 | Autobahn Therapeutics, Inc. | Novel thyromimetics |
| IL293389B1 (en) | 2019-11-29 | 2025-12-01 | Autobahn Therapeutics Inc | Novel thyromimetics |
| AU2020396561A1 (en) | 2019-12-04 | 2022-07-14 | Ashvattha Therapeutics, Inc. | Dendrimer compositions and methods for drug delivery to the eye |
| CN111116684B (zh) * | 2019-12-31 | 2020-09-25 | 厦门甘宝利生物医药有限公司 | 一种具有甲状腺激素受体激动剂特性的肝靶向化合物及其药物组合物 |
| US12528761B2 (en) | 2020-06-17 | 2026-01-20 | Autobahn Therapeutics, Inc. | Thyromimetics |
| WO2023081458A1 (en) * | 2021-11-08 | 2023-05-11 | Rutgers, The State University Of New Jersey | Systems and methods for diagnosis and/or treating demyelinating neuropathy |
| CN115569233B (zh) * | 2022-10-17 | 2023-07-14 | 湖南大学 | 既能吸光又能与自由基反应的高效光抑制剂的制备方法 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3815221C2 (de) | 1988-05-04 | 1995-06-29 | Gradinger F Hermes Pharma | Verwendung einer Retinol- und/oder Retinsäureester enthaltenden pharmazeutischen Zubereitung zur Inhalation zur Einwirkung auf die Schleimhäute des Tracheo-Bronchialtraktes einschließlich der Lungenalveolen |
| US6236946B1 (en) | 1995-12-13 | 2001-05-22 | Thomas S. Scanlan | Nuclear receptor ligands and ligand binding domains |
| JP3345428B2 (ja) | 1996-08-20 | 2002-11-18 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 合成甲状腺ホルマン組成物を使用した眼の処置 |
| US5883294A (en) | 1997-06-18 | 1999-03-16 | The Regeants Of The University Of California | Selective thyroid hormone analogs |
| AU4840199A (en) | 1998-06-30 | 2000-01-17 | Regents Of The University Of California, The | Thyroid hormone analogues and methods for their preparation |
| US7560433B2 (en) | 2001-12-21 | 2009-07-14 | Biotempt B.V. | Treatment of multiple sclerosis (MS) |
| US7302347B2 (en) | 2002-12-10 | 2007-11-27 | The Regents Of The University Of California | Method for creating specific, high affinity nuclear receptor pharmaceuticals |
| US8071134B2 (en) * | 2003-09-15 | 2011-12-06 | Ordway Research Institute, Inc. | Thyroid hormone analogs and methods of use |
| WO2005027895A2 (en) * | 2003-09-15 | 2005-03-31 | Ordway Research Institute | Thyroid hormone analogs and methods of use in angiogenesis |
| WO2006012015A2 (en) | 2004-06-29 | 2006-02-02 | Oregon Health And Science University | Methods and compositions for nerve regeneration |
| JP2008513461A (ja) * | 2004-09-15 | 2008-05-01 | オードウェイ リサーチ インスティテュート | 血管形成を促進する甲状腺ホルモンアナログ |
| US20090117054A1 (en) | 2005-03-29 | 2009-05-07 | University Of Kentucky Research Foundation | Sublingual spray for the treatment of pain |
| US8252329B2 (en) | 2007-01-05 | 2012-08-28 | Acelrx Pharmaceuticals, Inc. | Bioadhesive drug formulations for oral transmucosal delivery |
| JP2010506955A (ja) * | 2006-10-20 | 2010-03-04 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | 可溶性リンホトキシンβレセプターによる脱髄障害の処置 |
| CN101610774B (zh) * | 2006-11-03 | 2012-04-04 | 萨斯喀彻温大学 | 治疗脱髓鞘疾病的方法 |
| FI20075245A0 (fi) * | 2007-04-11 | 2007-04-11 | Markku Ahotupa | Menetelmä oksidatiivisen metabolian arvioimiseksi |
| EP2567699A1 (en) | 2007-07-11 | 2013-03-13 | MediciNova, Inc. | Treatment of progressive neurodegenerative disease with ibudilast |
| WO2009097995A1 (de) * | 2008-02-07 | 2009-08-13 | Sanofi-Aventis | Neue phenyl-substituierte imidazolidine, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| KR101449785B1 (ko) * | 2008-04-21 | 2014-10-14 | 오토노미, 인코포레이티드 | 귀 질환 및 병태를 치료하기 위한 귀 조제물 |
| WO2010144943A1 (en) | 2009-05-20 | 2010-12-23 | Ozpharma Pty Ltd | Buccal and/or sublingual therapeutic formulation |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| EA031156B1 (ru) | 2010-12-16 | 2018-11-30 | Суновион Фармасьютикалз Инк. | Сублингвальные пленки |
| EP2911924B1 (en) * | 2012-10-25 | 2017-06-21 | Volvo Truck Corporation | Electronically controlled pneumatic brake system for an automotive vehicle, automotive vehicle equipped with such a system and method for controlling such a system |
| JP2016517883A (ja) | 2013-05-03 | 2016-06-20 | オレゴン ヘルス アンド サイエンス ユニバーシティー | Ｘ連鎖副腎白質ジストロフィーの処置におけるソベチロムの使用 |
-
2013
- 2013-08-05 JP JP2016511718A patent/JP2016517883A/ja not_active Withdrawn
- 2013-08-05 WO PCT/US2013/053640 patent/WO2014178892A1/en not_active Ceased
-
2014
- 2014-02-05 ES ES14791718T patent/ES2745532T3/es active Active
- 2014-02-05 JP JP2016511726A patent/JP6360552B6/ja active Active
- 2014-02-05 US US14/888,577 patent/US10226438B2/en active Active
- 2014-02-05 WO PCT/US2014/014943 patent/WO2014178931A1/en not_active Ceased
- 2014-02-05 SG SG11201509012QA patent/SG11201509012QA/en unknown
- 2014-02-05 MX MX2015015228A patent/MX379043B/es unknown
- 2014-02-05 RU RU2015151216A patent/RU2015151216A/ru not_active Application Discontinuation
- 2014-02-05 SG SG10201709090UA patent/SG10201709090UA/en unknown
- 2014-02-05 BR BR112015027682A patent/BR112015027682A2/pt not_active IP Right Cessation
- 2014-02-05 EP EP14791718.1A patent/EP2991670B8/en active Active
- 2014-02-05 AU AU2014260468A patent/AU2014260468A1/en not_active Abandoned
- 2014-02-05 CA CA2911309A patent/CA2911309A1/en not_active Abandoned
- 2014-02-05 CN CN201480038129.XA patent/CN105431163A/zh active Pending
-
2015
- 2015-10-30 MX MX2021000538A patent/MX2021000538A/es unknown
-
2018
- 2018-06-22 JP JP2018118891A patent/JP2018141024A/ja active Pending
- 2018-07-23 JP JP2018137754A patent/JP2018162321A/ja active Pending
-
2019
- 2019-02-13 US US16/275,117 patent/US20190175531A1/en not_active Abandoned
-
2020
- 2020-07-07 US US16/922,852 patent/US11510887B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP6360552B2 (ja) | 2018-07-18 |
| SG11201509012QA (en) | 2015-11-27 |
| EP2991670A1 (en) | 2016-03-09 |
| RU2015151216A (ru) | 2017-06-08 |
| SG10201709090UA (en) | 2017-12-28 |
| US20200405669A1 (en) | 2020-12-31 |
| JP2016517883A (ja) | 2016-06-20 |
| MX2021000538A (es) | 2021-04-28 |
| WO2014178931A1 (en) | 2014-11-06 |
| WO2014178931A8 (en) | 2015-11-26 |
| JP2018162321A (ja) | 2018-10-18 |
| CA2911309A1 (en) | 2014-11-06 |
| ES2745532T3 (es) | 2020-03-02 |
| AU2014260468A1 (en) | 2015-11-19 |
| MX379043B (es) | 2025-03-10 |
| US10226438B2 (en) | 2019-03-12 |
| EP2991670B8 (en) | 2019-09-11 |
| MX2015015228A (es) | 2016-10-03 |
| US20160081955A1 (en) | 2016-03-24 |
| US20190175531A1 (en) | 2019-06-13 |
| CN105431163A (zh) | 2016-03-23 |
| HK1222552A1 (en) | 2017-07-07 |
| WO2014178892A8 (en) | 2015-12-17 |
| JP6360552B6 (ja) | 2018-08-15 |
| JP2016517884A (ja) | 2016-06-20 |
| EP2991670A4 (en) | 2017-01-18 |
| EP2991670B1 (en) | 2019-07-03 |
| US11510887B2 (en) | 2022-11-29 |
| WO2014178892A1 (en) | 2014-11-06 |
| JP2018141024A (ja) | 2018-09-13 |
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